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Theses/Dissertations

2013

Graduate Theses and Dissertations

Animal Sciences

Calpain

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Characterization Of The Skeletal Muscle Calpain/Calpastatin System In Growth Models In Swine And Cattle, Shannon Michelle Cruzen Jan 2013

Characterization Of The Skeletal Muscle Calpain/Calpastatin System In Growth Models In Swine And Cattle, Shannon Michelle Cruzen

Graduate Theses and Dissertations

The overall objective of the work in this dissertation was to characterize -calpain, m-calpain, and calpastatin activities in order to learn more about the system in the live animal as well as its potential effects on postmortem proteolysis. Animal models of efficiency and growth were used to achieve this objective.

The first specific objective was to evaluate muscle protein turnover differences in pigs selected for residual feed intake (RFI). Muscle samples were collected, and insulin signaling, protein synthesis, and specific protein degradation proteins were analyzed for expression and activities in twelve gilts each from low (LRFI) and high (HRFI) RFI ...