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Theses/Dissertations

2013

Graduate Theses and Dissertations

Animal Sciences

Barn dust

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Characterizing The Porcine Immune Response To An Environmental And Pathogenic Challenge: Swine Barn Dust And Salmonella Infection, Susan Knetter Jan 2013

Characterizing The Porcine Immune Response To An Environmental And Pathogenic Challenge: Swine Barn Dust And Salmonella Infection, Susan Knetter

Graduate Theses and Dissertations

Pork is the most highly consumed meat worldwide, and the swine industry generates $34.5 billion annually to the U.S. economy alone. Maintaining pork safety and minimizing production losses associated with swine disease impacts profitability, food safety and animal health. As such, the research presented herein focused on characterizing aspects of the porcine immune response to two challenges that impact swine health: swine barn dust exposure and Salmonella infection.

In the first set of experiments, swine barn organic dust extract (ODE) treatment negatively affected porcine macrophage phagocytosis, intracellular bacterial killing and NF-kB translocation. Further, ODE stimulated production of inflammatory ...