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Full-Text Articles in Life Sciences

Connecting The Dots: Understanding Migration In The Context Of Other Periods Of The Annual Cycle, Kristina Lee Paxton Dec 2013

Connecting The Dots: Understanding Migration In The Context Of Other Periods Of The Annual Cycle, Kristina Lee Paxton

Dissertations

Migration is a fundamental characteristic of the life history of many organisms. Large-scale seasonal movements expose migratory species to an array of differing environmental conditions such that the ecology, behavior, and life history strategies of migratory species must balance selection pressures associated with each phase of the annual cycle. Therefore, scientists increasingly realize that to understand the ecology of a migratory species in any one phase of the annual cycle requires an understanding of how other phases may interact with and influence the period of interest. That said, following individuals throughout the year poses a serious challenge.

The focus of ...


Racial Differences In Self-Efficacy Expectations For Exercise, Selena P. Smith Dec 2013

Racial Differences In Self-Efficacy Expectations For Exercise, Selena P. Smith

Honors Theses

This project examined the link between race and self-efficacy. Self-efficacy pertains to an individual’s confidence in ability to complete or engage in a particular task or activity (Bandura, 1986). Prior research shows that self-efficacy has a great influence on exercise initiation and adherence (Bandura, 1986; Dishman, 1982; Rodgers and Sullivan, 2001). Research also supports that Caucasians are more likely to participate in exercise than African Americans (Centers for Disease Control and Prevention, 2000).

Participants included 51 females, 31 Caucasians and 20 African Americans, between the ages of 18 and 50 years old. The women were recruited from local fitness ...


Age, Growth, Mortality, And The Effects Of Trawling On Mortality Of The Longspine Porgy, Stenotomus Caprinus, Cher Marie Newman Oct 2013

Age, Growth, Mortality, And The Effects Of Trawling On Mortality Of The Longspine Porgy, Stenotomus Caprinus, Cher Marie Newman

Master's Theses

Stenotomus caprinus (Longspine Porgy) is one of the most abundant bycatch species caught in trawl fisheries in the northern Gulf of Mexico (GOM). Biological data of length, weight, and abundance have been collected since 1972 on the Southeast Area Monitoring and Assessment Program (SEAMAP) surveys with a variety of GOM species, including Longspine Porgy, using trawl nets during groundfish surveys. In 2010-2011 five Longspine Porgy were obtained from Groundfish and Pelagic surveys at each station for further analysis. Age distribution was determined through von Bertalanffy length and weight-age models. The samples were separated into two regions of the GOM to ...


Assessing Respiration Rates And Nutrient Dynamics Of Aritifical Reef Biofilms And Bacterioplankton In The Mississippi Sound, Lynn Elizabeth Wilking Oct 2013

Assessing Respiration Rates And Nutrient Dynamics Of Aritifical Reef Biofilms And Bacterioplankton In The Mississippi Sound, Lynn Elizabeth Wilking

Master's Theses

Artificial reefs are primarily used to provide a suitable habitat for target fish populations, but the structures can also improve water quality and benefit non-target organisms. Laboratory incubation experiments were conducted in the presence of biofilm on rubble and in its absence to examine bacterial growth, community respiration, and nutrient dynamics at four artificial reef habitats in the Mississippi Sound. Biofilm samples were also collected from settlement plates deployed at each site and were analyzed for 813C and 81sN stable isotope content. Respiration rates were always higher in the presence of biofilm but bacterial abundance often declined over time, and ...


Role Of Msa In Immune Evasion, Persistence, And Protease Regulation In The Human Pathogenic Strains Of Staphylococcus Aureus, Maria Deepa Basco Aug 2013

Role Of Msa In Immune Evasion, Persistence, And Protease Regulation In The Human Pathogenic Strains Of Staphylococcus Aureus, Maria Deepa Basco

Dissertations

Opportunistic pathogens like Staphylococcus aureus on entering the host can stay colonized at the foci of infection or evade the immune system to disseminate to other sites. In this study we investigated the regulatory influence of the modulator of sarA (msa) on immune evasion and host persistence, employing the hospital-acquired strain S. aureus UAMS-1 and community-acquired strain S. aureus USA300 LAC. In the murine sepsis model, mutation of the msa gene in LAC showed no change in dissemination of infection; however, in UAMS-1 a decrease in microbial load was observed in the lungs. Differential regulation by the msa gene was ...


Characterizing The Persistence Of Sewage Enterococci In Mississippi Coastal Waters, Kimberly Anne-Marie Lewis Aug 2013

Characterizing The Persistence Of Sewage Enterococci In Mississippi Coastal Waters, Kimberly Anne-Marie Lewis

Master's Theses

Enterococci are microbiological indicators of marine recreation water quality.
Their reliability as fecal indicators is questioned as they are shown to persist in the environment. Multiple laboratory studies on their persistence have been done but few under natural environmental conditions. The purpose of this study was to investigate how long sewage enterococci and enterococcal DNA persist in beach water and to determine whether there is a difference in the genetic diversity and hardiness of sewage vs. environmental isolates. To study persistence, sewage was diluted with beach water, placed in microcosms, and deployed at a beach site in Longbeach and Pass ...


An Insight Into The Microbial Diversity And Expression Of Cysteine Protease Inhibitors (Cystatin) In Rickettsia Parkeri Infected Amblyomma Maculatum, Khemraj Budachetri Aug 2013

An Insight Into The Microbial Diversity And Expression Of Cysteine Protease Inhibitors (Cystatin) In Rickettsia Parkeri Infected Amblyomma Maculatum, Khemraj Budachetri

Master's Theses

Amblyomma maculatum (Gulf Coast tick) is an emerging tick species of public health significance in United States. It is a competent vector of Rickettsia parkeri, an etiological agent of a human rickettsiosis. In this study, we investigated the spotted fever group of rickettsial diversity in A. maculatum based on rickettsial ompA gene PCR. Our results showed A. maculatum harbors R. parkeri, R. amblyommii, and R. endosymbiont of A. maculatum. While only R. parkeri was detected in female salivary glands which suggest its ability to traffic from midgut to salivary glands via hemocoel. The presence of R. parkeri was further confirmed ...


Developmental Expression Profile Of Bric Á Brac 2, Midline And H15 In The Developing Eye And Central Nervous System Of Drosophila Melanogaster, Petra Visic Aug 2013

Developmental Expression Profile Of Bric Á Brac 2, Midline And H15 In The Developing Eye And Central Nervous System Of Drosophila Melanogaster, Petra Visic

Honors Theses

Aberrant activity of a single gene can lead towards development of cancerous cells. Drosophila melanogaster is a useful model system to study cancer because there is high degree of evolutionary conservation in signaling pathways between humans and flies that play major roles in regulating cell proliferation and growth (Miles et al., 2011). At The University of Southern Mississippi (USM), Dr. Leal’s lab has gathered evidence suggesting that bab1 and bab2 interact with the T-box gene midline (mid) and its paralog H15, while the early developmental function of bab1 and bab2 remains unknown. That is why elucidating the early interactions ...


Science Fair: Is It Worth The Work? A Qualitative Study On Deaf Students' Perceptions And Experiences Regarding Science Fair In Primary And Secondary School, Vivian Lee Smith Aug 2013

Science Fair: Is It Worth The Work? A Qualitative Study On Deaf Students' Perceptions And Experiences Regarding Science Fair In Primary And Secondary School, Vivian Lee Smith

Dissertations

Science fairs have a long history in American education. They play an important role for establishing inquiry-based experiences in a science classroom. Students may be more motivated to learn science content when they are allowed to choose their own science fair topics. The purpose of this study was to examine Deaf college students’ perceptions and experiences regarding science fair participation during primary and/or secondary school and determine the influence of science fair involvement on the development of language skills, writing skills, and higher order thinking skills as well as its impact on choice of a STEM major.

This study ...


Molecular Detection Of Tick-Borne Pathogens Associated With Ixodid Tick Species Infesting Migratory Songbirds And Ruminants, Nabanita Mukherjee Jul 2013

Molecular Detection Of Tick-Borne Pathogens Associated With Ixodid Tick Species Infesting Migratory Songbirds And Ruminants, Nabanita Mukherjee

Master's Theses

Ticks are hematophagous arthropods and capable of inoculating various infectious agents to their vertebrate hosts. Ticks attached to birds and ruminants are capable of carrying tick-transmitted microorganisms. In our study, the prevalence of tick-borne pathogens was examined in ticks infesting migratory songbirds and Pakistani ruminants. During spring migration seasons, ticks were removed from northward-migrating songbirds in Louisiana and identified as Amblyomma Jongirostre, Amblyomma nodosum, Amb/yomma ca/caratum, Amblyomma maculatum, and Haemaphysalis species, all are considered as Neotropical ticks. Ticks removed from ruminants were identified as Hya/omma anatolicum, Hyalomma dromedarii, Rhipicephalus microplus, and Rhipicephalus sanguineus. A total of 112 ...


Development Of A Genetic Monitoring Program For Stock Enhancement Of Mississippi Spotted Seatrout (Cynoscion Nebulosus), Carly Renee Somerset Jul 2013

Development Of A Genetic Monitoring Program For Stock Enhancement Of Mississippi Spotted Seatrout (Cynoscion Nebulosus), Carly Renee Somerset

Master's Theses

The spotted seatrout is a coastal sciaenid fish that is intensively exploited in the northcentral Gulf of Mexico. A stock enhancement research program was initiated in 2004 to develop methods to culture juveniles and release them in natural habitats to increase recruitment in the fishery. The goal of this study was to initiate a genetic monitoring program for stock enhancement activities. Assays for 15 microsatellite loci were optimized. Simulations indicated that this panel of molecular markers was sufficient to identify recaptured hatchery fish with high confidence assuming genetic data on broodfish spawned to produce released fish were available. Stock structure ...


Comparative Analysis Of Antiviral Responses In Mouse Embryonic Stem Cells And In Mesenchymal Stem Cells, Jundi Wang Jul 2013

Comparative Analysis Of Antiviral Responses In Mouse Embryonic Stem Cells And In Mesenchymal Stem Cells, Jundi Wang

Master's Theses

Embryonic stem cells (ESCs) are cells that have unlimited capacity for selfrenewal and differentiation. These properties make ESCs a great cell source for application in regenerative medicine. When used for cell therapy, ESC-derived cells could be placed in a wounded area that is likely to be exposed to various pathogens. However, it is not well-understood whether ESCs and ESC-derived cells have active antiviral responses against infectious agents from the environment. To answer this important question, I comparatively analyzed the antiviral responses of ESCs and mesenchymal stem cells (MSCs, C3H10Tl/2 cell line) to infectious agents. Using the expression of type ...


The Relationship Between Calcium Intake And Body Mass Index In The Participants Of Hub City Steps, Laura P. Ewoldt May 2013

The Relationship Between Calcium Intake And Body Mass Index In The Participants Of Hub City Steps, Laura P. Ewoldt

Honors Theses

Background: The social, economic, and health impacts of unhealthy dietary behaviors and sedentary lifestyles are quite significant and even more so in the rural South. The majority of individuals in the US do not adhere to the Dietary Guidelines for Americans, specifically fruits, vegetables, and calcium.

Purpose: The purpose of this study was to address the issue of calcium intake and obesity in a population of primarily African American women in south Mississippi and to determine if levels of calcium intake had a relationship with body mass index.

Methods and Analysis: Data for the current study was collected through the ...


Plasmodium Prevalence In Northern Cardinals Over An Eight Month Period, Kaylee M. Gentry May 2013

Plasmodium Prevalence In Northern Cardinals Over An Eight Month Period, Kaylee M. Gentry

Honors Theses

This study implemented microscopic assays on field collected data to assess the prevalence of avian malaria in a non-migratory species, Cardinalis cardinalis. Following capture, blood smears were collected from birds at the University of Southern Mississippi’s Lake Thoreau Environmental Education and Research Center over an eight month period from September 2012 to March 2013. These smears were then stained using a Hema 3 stain set and microscopically assessed for the presence of Plasmodium relictum (avian malaria). Stained blood smear samples from a migrant species, Junco hyemalis, were used for comparisons of malarial infection. Additionally, corticosterone (CORT) assays were preformed ...


Drosophila T-Box Transcription Factor Midline Functions In The Notch-Delta Signaling Pathway To Regulate Sensory Organ Precursor Cell Fate And Cell Survival And Embryonic Development Profile Of Midline, Senseless, And Achaete In The Cns And Pns, Joseph D. Saucier May 2013

Drosophila T-Box Transcription Factor Midline Functions In The Notch-Delta Signaling Pathway To Regulate Sensory Organ Precursor Cell Fate And Cell Survival And Embryonic Development Profile Of Midline, Senseless, And Achaete In The Cns And Pns, Joseph D. Saucier

Honors Theses

The gene mid of Drosophila is a highly conserved gene that codes for a T-box transcription factor with similar functionality to its vertebrate homolog Tbx20. Mid and Tbx20 are important for their roles in heart and CNS development. Additionally, these transcription factors aid in proper eye development but this area of research is vastly understudied. This study uses the eye of Drosophila to report that mid and its paralog H15 expression aid in the specification of sensory organ precursor (SOP) cell fates and cell survival in the pupal eye imaginal disc. Using RNAi interference to reduce mid expression resulted in ...


Targeted Delivery Of Ribonucleotide Reductase Sirna In Cancer Cells Via Gold Nanoplexes, John Caleb Grenn May 2013

Targeted Delivery Of Ribonucleotide Reductase Sirna In Cancer Cells Via Gold Nanoplexes, John Caleb Grenn

Honors Theses

Cancer treatment has much room for improvement, as therapies today cannot differentiate well between what cells are part of a tumor and which are healthy. Our research involves targeting cancer cells by their overexpressed folic acid receptors, and delivering small interfering RNAs (siRNAs) to silence genes crucial to cell survival by the RNA interference gene knockdown pathway. By using Gaussia luciferase siRNA (siGLuc) as a model for cell delivery, we have been able to test our ability to deliver siRNA via a gold nanoparticle delivery system, also developed in our lab. We also synthesized ribonucleotide reductase siRNA (siRRM2), which will ...


Interrelationships Between Testosterone, Aggression, And Parental Care Of A Temperate-Zone, Resident Songbird, The Northern Cardinal (Cardinalis Cardinalis), Margaret Susan Devries May 2013

Interrelationships Between Testosterone, Aggression, And Parental Care Of A Temperate-Zone, Resident Songbird, The Northern Cardinal (Cardinalis Cardinalis), Margaret Susan Devries

Dissertations

Interrelationships among testosterone (T), aggression, and parental care have received much investigative attention. Within birds, many studies have focused on examining such relationships using species characterized by relatively brief periods of territoriality and breeding. Few have investigated links between circulating T and reproductive behavior in birds that are year-round territorial residents and have lengthy breeding seasons, such as the Northern Cardinal (Cardinalis cardinalis). The following six chapters report and discuss findings from this dissertation’s examination of aspects of T production and potential interconnections with circulating T, aggression, and parental care in male and female cardinals. This work suggests that ...


Community Metrics And Trophic Dynamics In Tidal Creeks In An Anthropogenically Fragmented, Coastal Landscape, Michael Robert Lowe May 2013

Community Metrics And Trophic Dynamics In Tidal Creeks In An Anthropogenically Fragmented, Coastal Landscape, Michael Robert Lowe

Dissertations

Salt marsh landscapes are among the most anthropogenically altered ecosystems in the world. Urbanization (i.e., accumulation of impervious cover and man made structrues) of the coastal landscape can disrupt the delivery of numerous ecosystem services. Among the many services provided by salt marsh habitats, they serves as the primary habitats for distinct macroinfauna (i.e., benthic and epibenthic macrofauna) and nekton (i.e., fish and decapod crustaceans) assemblages. In this dissertation, I used a number of metrics to test the overarching hypothesis that coastal urbanization has negative consequences for salt marsh faunal assemblages. Chapter I uses a landscape ecology ...


A Bird In The Binoculars: Understanding Birdwatchers' Potential To Contribute To Sustainable Development And Biological Conservation, Sheri Lynn Glowinski May 2013

A Bird In The Binoculars: Understanding Birdwatchers' Potential To Contribute To Sustainable Development And Biological Conservation, Sheri Lynn Glowinski

Dissertations

The three studies comprising this research drew from local economic development and environmental sociology to understand aspects of human dynamics that influence the conservation of birds. Using survey data collected from birdwatchers visiting coastal Alabama, the first study examined the local economic impact of birdwatching tourism and the factors that participants deemed important with respect to their recreation. Birdwatchers spent $103,305 during the four month study period. The total annual economic impact of this recreation on the area was estimated at $937,470, producing a multiplier of 1.48 and the equivalent of 20.3 full time jobs. Infrastructural ...


Phytoplankton Community Distribution And Light Absorption Properties In The Northern Gulf Of Mexico, Sumit Chakraborty May 2013

Phytoplankton Community Distribution And Light Absorption Properties In The Northern Gulf Of Mexico, Sumit Chakraborty

Dissertations

The theme of this dissertation was to understand the spatio-temporal dynamics of the phytoplankton community, its light absorption properties, and its relationship to underlying physicochemical processes. Understanding these phenomena will benefit efforts to predict pathways of carbon transformation in the ocean, to estimate primary productivity (PP) and to characterize distributions of phytoplankton communities using ocean color remote sensing.

This research entailed four different studies, which address different objectives. The first two studies dealt with phytoplankton community composition and its relationship to environmental variables. A chemotaxonomic approach was used, which was successful in revealing distinct phytoplankton assemblages in distinct water mass ...


Evaluation Of Human Fecal Pollution In Mississippi Coastal And Creek Waters Using Library Independent Markers, Christopher John Flood May 2013

Evaluation Of Human Fecal Pollution In Mississippi Coastal And Creek Waters Using Library Independent Markers, Christopher John Flood

Dissertations

The objective of this study was to determine whether statistically valid correlations could be elucidated between standard indicator bacteria (enterococci and fecal coliforms) from coastal creek and marine samples and the presence of four library independent molecular markers that are human or sewage specific. Eight hundred and nineteen samples were collected between August 2007 and July 2010 to determine enterococcal and fecal coliform counts and the presence of genetic markers for sewage indicator organisms Methanobrevibacter smithii, human specific Bacteroides sp., Bacteroides thetaiotaomicron, and Fecalibacterium sp. During the course of this study environmental parameters were measured and statistically analyzed to determine ...


Habitat Characterization, Habitat Use And Associated Growth Of Juvenile Spotted Seatrout (Cynoscion Nebulosus) In A Mississippi Bay System: Implications For Stock Enhancement Practices, Joseph Read Hendon May 2013

Habitat Characterization, Habitat Use And Associated Growth Of Juvenile Spotted Seatrout (Cynoscion Nebulosus) In A Mississippi Bay System: Implications For Stock Enhancement Practices, Joseph Read Hendon

Dissertations

The spotted seatrout (Cynoscion nebulosus) is the most targeted recreational fishery species in Mississippi coastal waters. Consequently, the Seatrout Population Enhancement Cooperative stock enhancement program was initiated to investigate methods for supplementing this heavily exploited population. Given ecological data needs for both wild and hatchery-reared (HR) juveniles of the species, habitat mapping, directed sampling and a caging study were conducted. Submerged aquatic vegetation (SAV), oyster shell and non-vegetated substrates were mapped at water depths < 2 m in Point aux Chenes Bay, Mississippi, using a sidescan sonar, which provided more accurate estimations of habitat coverage, particularly for SAV, compared to point-based sampling. Applying habitat strata delineated from sidescan mapping, late-juvenile spotted seatrout [125 - 275 mm total length (TL)] were sampled in SAV, marsh-edge and non-vegetated habitats as part of a seasonal gill net survey conducted in 2011 and 2012. Spotted seatrout ranging from 138 to 485 mm TL were collected using a smallmesh gill net, and 65% of collected individuals fell within the targeted late-juvenile size range. Overall mean catch-per-unit-effort of C. nebulosus did not differ for abundance or biomass between years, but both metrics were significantly higher in SAV habitats. Employing cage enclosures that excluded predators ...


Investigating The Function Of The Mold Specific Gene M46, In The Pathogenic Dimorphic Fungus Histoplasma Capsulatum, Davida Lashaundra Crossley May 2013

Investigating The Function Of The Mold Specific Gene M46, In The Pathogenic Dimorphic Fungus Histoplasma Capsulatum, Davida Lashaundra Crossley

Dissertations

Histoplasma capsulatum (Hc) is a dimorphic fungus that is the etiologic agent for the respiratory infection histoplasmosis. The fungus is found in the environment in contaminated soils of birds and bat excreta as a multi-cellular saprophytic mold. Once the soil is disturbed, spores are released and are inhaled into the lungs. In the lungs, the fungus converts to uni-cellular parasitic yeast (Maresca & Kobayashi, 1989). The conversion from mold to yeast is a requirement for pathogenesis. Previously, several mold specific genes have been isolated by our laboratory from a subtracted cDNA library. One such gene, is M46. M46 is a single ...


Characterization Of Whole Pine Tree Substrates For Adventitious Rooting Of Cuttings And Initial Growth Of Seedlings, Anthony Lynn Witcher May 2013

Characterization Of Whole Pine Tree Substrates For Adventitious Rooting Of Cuttings And Initial Growth Of Seedlings, Anthony Lynn Witcher

Dissertations

Processed whole pine (Pinus taeda L.) trees have been extensively evaluated to supplement peatmoss and pine bark usage in container substrates for greenhouse and nursery crop production. The suitability of whole pine tree (WPT) substrates for crop propagation has not been investigated. Demonstrating the versatility of WPT substrates is essential to expanding their commercial availability and use.

The objective of this work was to evaluate WPT substrates for stem cutting and seed propagation of ornamental crops, and to identify factors affecting root development. Stem cutting and seedling root development was evaluated in WPT and traditional (peatmoss and pine bark) substrates ...


Mississippi's First Annual Farm To School Week: Evaluation Of School Participation, Kelsey Jean Lingsch May 2013

Mississippi's First Annual Farm To School Week: Evaluation Of School Participation, Kelsey Jean Lingsch

Master's Theses

Mississippi has recently established the first week of October as statewide Farm to School (F2S) Week, providing Mississippi the opportunity to improve the health status of children while improving the local economy. The study aimed to measure Mississippi school districts' participation during F2S Week 2012 and identify perceived barriers and future interest of participation among child nutrition directors (CND). An electronic survey was sent to the 156 CNDs in the state of Mississippi participating in the National School Lunch Program. Data were analyzed in SPSS v.20 using descriptive and correlational statistics. Among the 75 CNDs who responded to the ...


The Trap-Neuter-Return Program As A Means For Collecting, Analyzing, And Comparing Data In Animal Care Facilities In Florida, Louisiana, And Mississippi, Stephanie T. Doty May 2013

The Trap-Neuter-Return Program As A Means For Collecting, Analyzing, And Comparing Data In Animal Care Facilities In Florida, Louisiana, And Mississippi, Stephanie T. Doty

Honors Theses

The TNR program has been met with both scrutiny and approval as a result of conflicting data from studies that examine its usefulness as a means of controlling the free-roaming cat population explosion (Levy & Crawford, 2004). Though the differing opinions will be discussed, it is not the intention of this paper to provide evidence in support of one or the other; instead, the purpose is to examine the various clinics’ implementation of the TNR program and its usefulness in providing data. In addition, an analysis of the data was done to determine what they may suggest about the free-roaming cat populations in the different areas. At the time of this writing, there are no known published data collections for free-roaming cats in the regions examined in this ...


Attempt To Synthesize The (S) Enantiomer Of A Glutathione Analog To Be An Inhibitor Of Glutathione Reductase, Sidney L. Mcclendon May 2013

Attempt To Synthesize The (S) Enantiomer Of A Glutathione Analog To Be An Inhibitor Of Glutathione Reductase, Sidney L. Mcclendon

Honors Theses

Malaria is a disease of the blood that is caused by a parasite and affects over forty percent of the world population today. This small parasite can be treated in a very short period of time; however, there are many countries that do not have access to advanced medicine. This means that the people infected with this disease will usually die from complications arising from the illness. Malaria is prevalent in tropical and subtropical countries close to the equator where more than half of the world’s population resides. Dominance of malaria in these areas is because of the low ...


Deletion Of Putative Msa Operon Gene Fragment And Its Phenotypic Characterization In Community Acquired-Methicillin Resistant Staphylococcus Aureus Usa300 Strain Lac, Reem A. Dawoud May 2013

Deletion Of Putative Msa Operon Gene Fragment And Its Phenotypic Characterization In Community Acquired-Methicillin Resistant Staphylococcus Aureus Usa300 Strain Lac, Reem A. Dawoud

Honors Theses

Staphylococcus aureus is an important human pathogen that causes a wide variety of diseases. Many S. aureus strains have emerged which are resistant to the penicillin class of antibiotics. Of primary importance is methicillin-resistant S. aureus (MRSA), which has cause frequent hospitalizations due to infections. In the past, MRSA was typically confined to hospital settings, but recently, community-associated MRSA (CA-MRSA) have been reported. CA-MRSA poses a major public health threat because of increased virulence and success in infecting otherwise healthy individuals. Previously we discovered a gene, msa, which plays a critical role in biofilm formation and regulation of the disease ...


Exploring The Interactions Between Interleukin-8 (Il8) And Amyloid-Β (Aβ) Peptide In Traumatic Brain Injury, Olivia G. Gibson May 2013

Exploring The Interactions Between Interleukin-8 (Il8) And Amyloid-Β (Aβ) Peptide In Traumatic Brain Injury, Olivia G. Gibson

Honors Theses

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive dysfunction and memory loss, and pathologically characterized by amyloid-beta (Aβ) plaques and inflammation. Recent research has shown that these Aβ plaques are also found in traumatic

brain injury (TBI) patients. This discovery has led to a proposed pathway leading from traumatic brain injuries to dementia, more specifically AD. After a TBI, human granulin-A (GRN) and interleukin-8 (IL8) are released and the number of elastases in the brain increases in response to the inflammation response. IL8 is a cytokine that is released in acute inflammation responses, and the levels of ...


Biophysical Characterization And Cross-Seeding Properties Of Lfaos, Novel Prion-Like Oligomers Of The Amyloid-Beta Peptide Involved In Alzheimer’S Disease, Morgan C. Woodrow May 2013

Biophysical Characterization And Cross-Seeding Properties Of Lfaos, Novel Prion-Like Oligomers Of The Amyloid-Beta Peptide Involved In Alzheimer’S Disease, Morgan C. Woodrow

Honors Theses

The amyloid-beta (Aβ) protein is known to play an important role in the etiology of Alzheimer’s disease (AD). Aβ peptide aggregates in the brains of AD patients to form soluble oligomers as well as insoluble fibrils. Oligomers of Aβ are now known to be the primary toxic agents in AD. Evidence is beginning to emerge regarding a conserved prion-like propagation mechanism in AD. One of the principal characteristics of prion diseases is their ability to self-propagate via a template-assisted-corruptive mechanism. Our lab has previously characterized a unique ‘Aβ prion’ called Large Fatty-Acid- Derived Oligomers (LFAOs). This project examines the ...