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Full-Text Articles in Life Sciences
The Role Of A Camkii/Pka-Protein Degradation-Glur2 Pathway In The Control Of Memory Updating Following Retrieval, Timothy Jarome
Theses and Dissertations
Reconsolidation is thought to be a process whereby consolidated memories can be modified following retrieval. However, very little is known about the molecular mechanisms that regulate this reconsolidation process. In the present series of experiments we tested if memories "destabilize" or become labile following retrieval through a specific signaling pathway. We found that retrieval of a contextual fear memory differentially increased proteasome activity in the amygdala and hippocampus and resulted in unique changes in AMPA receptor subunit expression in these brain regions. These changes were dependent on CaMKII activity, which was required for increases in Rpt6-S120 phosphorylation, proteasome activity and ...
The Impact Of Motivation On Object-Based Visual Attention Indexed By Continuous Flash Suppression., Vanessa Troiani
Publicly Accessible Penn Dissertations
Motivationally-relevant stimuli summon our attention and benefit from enhanced processing, but the neural mechanisms underlying this prioritization are not well understood. Using an interocular suppression technique and functional neuroimaging, this work has the ultimate aim of understanding how motivation impacts visual perception. In Chapter 2a, we demonstrate that novel objects with a more rich reward history are prioritized in awareness more quickly than objects with a lean reward history. In Chapter 2b, we show that faces are prioritized in awareness following social rejection, and that the amount faces are prioritized correlates with individual differences in social motivation. Chapters 3 & 4 ...