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Full-Text Articles in Life Sciences
Change And Impact Of Microrna Modification With Age In Drosophila Melanogaster, Masashi Abe
Publicly Accessible Penn Dissertations
microRNAs (miRNAs) are 20~24nt small RNAs that are critical for many biological aspects, from development to age-associated processes. Starting from the identification of the first miRNA, lin-4, hundreds of miRNAs have been discovered across species. To reveal the role of miRNAs in aging, studies have profiled changes in miRNA levels with age. However, increasing evidence suggests that miRNAs show heterogeneity in length and sequence in different biological contexts. Despite the observation of such heterogeneity, it is largely unknown how such heterogeneity is generated, and whether it is biologically regulated or important. Here we report the characterization of a novel ...
Immunosenescence And Exercise-Mediated Modulation Of The Innate Immune Response To Influenza Infection In Mice, Shibani Naik
Graduate Theses and Dissertations
Influenza virus is a negative sense, single stranded RNA virus that can cause severe respiratory tract infections in humans (along with other host animals such as horses, swine and poultry). Certain populations such as very young children, aged individuals, pregnant women and immunosuppressed individuals are more susceptible to influenza infections. One reason for the increased susceptibility to infection in the aged is a decreased efficacy of the seasonal influenza vaccine. As this particular section of our population continues to increase worldwide, research to improve vaccine efficacy is expanding along with efforts to identify lifestyle changes and interventions that can improve ...