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Theses/Dissertations

2013

Pharmacology, Toxicology and Environmental Health

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Full-Text Articles in Life Sciences

Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence And Therapeutic Activation, Viralkumar M. Patel Dec 2013

Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence And Therapeutic Activation, Viralkumar M. Patel

UT GSBS Dissertations and Theses (Open Access)

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy. High levels of Bcl-2 and IAP family proteins are responsible for apoptotic-resistance and accumulation of mature CLL lymphocytes in bone-marrow, lymph nodes and peripheral blood. Besides pro-survival proteins, supporting stromal cells as well as soluble factors in the microenvironment of bone-marrow and lymph nodes provide survival advantage to CLL leukemic cells.

Though the stromal – leukemia cell interactions has been studied extensively, in-depth-knowledge on the regulation of apoptotic pathway proteins in the context of microenvironment is still limited. To address this, the first part of our study focused on comprehensive analysis of 93 ...


The Imperative Of Conserving California's Foothill Oak Woodlands, Lauren Phillips Dec 2013

The Imperative Of Conserving California's Foothill Oak Woodlands, Lauren Phillips

Social Sciences

No abstract provided.


Elucidating Mechanisms By Which Substance P In The Rvm Contributes To The Maintenance Of Pain Following Inflammatory Injury, Uche Patrick Maduka Dec 2013

Elucidating Mechanisms By Which Substance P In The Rvm Contributes To The Maintenance Of Pain Following Inflammatory Injury, Uche Patrick Maduka

Theses and Dissertations

Chronic pain is a major healthcare concern that directly affects over one hundred million people in the United States alone. While current treatment options like opioids and NSAIDs are effective, they are with significant drawbacks that prevent long term use. It is important to identify and understand new druggable targets for the treatment of pain. Recent findings have demonstrated substance P functions in the RVM to maintain hypersensitivity to noxious heat stimuli in models of persistent peripheral inflammatory injury in a manner dependent on presynaptic NMDA receptors. What remains unclear is how substance P assumes this pronociceptive role following peripheral ...


Population Pharmacokinetics And Exposure Toxicity Analysis Of Vatalanib In Patients With Myelodysplastic Syndromes, Xiaofeng Wang Dec 2013

Population Pharmacokinetics And Exposure Toxicity Analysis Of Vatalanib In Patients With Myelodysplastic Syndromes, Xiaofeng Wang

Theses and Dissertations

Vatalanib is a novel, potent, orally bioavailable angiogenesis inhibitor which can block all known vascular endothelial growth factor (VEGF) receptor tyrosine kinases. It has been shown to have potential in treating hematological malignancies, including myelodysplastic syndromes (MDS). Previous studies have revealed substantial pharmacokinetic variability that is further increased by auto-induction of its metabolism. And safety and tolerability are of great importance for such anti-angiogenic treatment. Therefore, the objectives of thesis was to characterize the pharmacokinetics and auto-induction process of vatalanib using population pharmacokinetic approaches, and to evaluate the relationship between systemic exposure to vatalanib and its toxicity in order to ...


Investigation Of The Structure And Dynamics Of Regioisomeric Eu³⁺ And Gd³⁺ Chelates Of Nb-Dotma: Implications For Mri Contrast Agent Design, Benjamin Charles Webber Nov 2013

Investigation Of The Structure And Dynamics Of Regioisomeric Eu³⁺ And Gd³⁺ Chelates Of Nb-Dotma: Implications For Mri Contrast Agent Design, Benjamin Charles Webber

Dissertations and Theses

The detection of disease and abnormal pathology by magnetic resonance imaging (MRI) has been aided significantly by the use of gadolinium (Gd3+)-based contrast agents (CAs) over the past three decades. MRI and MRI CAs play a critical role in diagnosing tumors and diseases of the central nervous system. The agents used clinically have been shown to safely increase MRI contrast despite the toxicity of Gd3+, owing to the high kinetic and thermodynamic stability of these chelates. However, current CAs enhance contrast at a small fraction of what is theoretically possible. This leads to the necessity of introducing ...


Selected Neuropharmacology Of Resurgence, Adam D. Pyszczynski Aug 2013

Selected Neuropharmacology Of Resurgence, Adam D. Pyszczynski

All Graduate Theses and Dissertations

Resurgence refers to the reappearance of an extinguished operant behavior when reinforcement for an alternative behavior is also discontinued. It is especially relevant to the reappearance of problem behavior because many behavioral interventions discontinue reinforcement for aberrant behavior while simultaneously reinforcing an appropriate response. Existing information about the neuropharmacology of resurgence is scarce, but suggests overlap between drug seeking observed in the resurgence model and drug seeking observed in the more widely studied reinstatement and renewal models. The aim of this dissertation was to explore additional neural systems relevant to reinstatement and renewal preparations within a resurgence paradigm to assess ...


Molecular Mechanisms Underlying The Early Life Programming Of The Liver, Gurjeev Sohi Jul 2013

Molecular Mechanisms Underlying The Early Life Programming Of The Liver, Gurjeev Sohi

Electronic Thesis and Dissertation Repository

Clinical studies have demonstrated that intrauterine growth restriction (IUGR) offspring, faced with a nutritional mismatch postpartum, have an increased risk of developing the metabolic syndrome. The maternal protein restriction (MPR) rat model has been extensively studied to investigate the adverse effects of a nutritional mismatch in postnatal life of IUGR offspring. Previous studies have demonstrated that MPR leads to impaired function of the liver, an important metabolic organ. However the underlying mechanisms which predispose these offspring to the metabolic syndrome remain elusive. In the following studies, low protein diet during pregnancy and lactation led to IUGR offspring with decreased liver ...


Function And Activation Mechanism Of Plekhg2, A Novel G Beta Gamma-Activated Rhogef In Leukemia Cells, Caitlin M. Runne Jul 2013

Function And Activation Mechanism Of Plekhg2, A Novel G Beta Gamma-Activated Rhogef In Leukemia Cells, Caitlin M. Runne

Theses and Dissertations

The Rho family of GTPases plays a crucial role in the regulation of diverse cellular processes, including proliferation and actin cytoskeletal rearrangement to promote cell migration. However, dysregulation of RhoGTPases has been associated with disease, particularly cancers such as leukemia. Despite this, RhoGTPases are rarely mutated in cancer. Rather, dysregulation of their regulatory proteins through mutation or overexpression contributes to disease pathogenesis. RhoGTPases are activated through Rho guanine nucleotide exchange factors (GEFs). Although over eighty RhoGEFs have been identified that activate the 25 RhoGTPases, the pathological role of the majority of these proteins remains unclear. Further, whereas the majority of ...


Dual Role Of Oxidative Stress In Head And Neck Cancer Chemotherapy: Cytotoxicity And Pro-Survival Autophagy, Arya Sobhakumari Jul 2013

Dual Role Of Oxidative Stress In Head And Neck Cancer Chemotherapy: Cytotoxicity And Pro-Survival Autophagy, Arya Sobhakumari

Theses and Dissertations

Cancer cells are believed to exist in a condition of metabolic oxidative stress compared to normal cells because of inherent mitochondrial dysfunction. Cancer cells up regulate antioxidant defense mechanisms to combat the toxic effect of reactive oxygen species (ROS). Many anticancer agents block ROS detoxification mechanisms and utilize oxidative stress to cause cytotoxicity to cancer cells. However, ROS also up-regulate many pro-survival signaling pathways that may mediate resistance to chemotherapy. I hypothesize that ROS induces both cytotoxicity and pro-survival mechanisms in cells treated with chemotherapeutic agents such as the EGFR inhibitor erlotinib. This thesis explores how oxidative stress may induce ...


N-Acetylcysteine As A Chemoprotectant Against Ifosfamide Nephrotoxicity; From Mechanism To Prevention, Lauren Hanly Jun 2013

N-Acetylcysteine As A Chemoprotectant Against Ifosfamide Nephrotoxicity; From Mechanism To Prevention, Lauren Hanly

Electronic Thesis and Dissertation Repository

The chemotherapy drug ifosfamide is used in the treatment of several childhood cancers. While effective, its use in children results in a 30% incidence of nephrotoxicity, and 5% incidence of Fanconi syndrome. This late effect is caused by oxidative damage, generated by chloroacetaldehyde, a toxic metabolite of ifosfamide cytochrome P450-mediated bioactivation in the kidney tubules. N-acetylcysteine has been identified as a promising strategy to mitigate nephrotoxicity through its antioxidant and glutathione stimulating properties. Furthermore, with current use in children for acetaminophen poisoning, its clinical utility is evident. Both cell and animal models have demonstrated n-acetylcysteine’s effectiveness in mitigating ifosfamide ...


Proton Induced X-Ray Emission Spectrometry Of Atmospheric Aerosols At Piseco Lake, Adam Margulies Jun 2013

Proton Induced X-Ray Emission Spectrometry Of Atmospheric Aerosols At Piseco Lake, Adam Margulies

Honors Theses

Chemical studies of lakes and aerosols in the Adirondack region of New York State have found evidence of environmental pollution resulting in acid rain. We obtained air samples for July and September 2012 from Piseco Lake and analyzed particulate depositions with Proton Induced X-ray Emission (PIXE) spectrometry. We detected an array of light elements, including sulfur particulates in the 0.25 - 8 μm range, possibly stemming from coal combustion in the Appalachians and Mid-West of the United States. We also found systematic errors with the accelerator charge integration system due to beam spreading after the beam passes through the target ...


Impact Of Hydraulic Fracturing On Ground And Surface Water Resources, Reyna Schenck Jun 2013

Impact Of Hydraulic Fracturing On Ground And Surface Water Resources, Reyna Schenck

Natural Resources Management and Environmental Sciences

The following study examines hydraulic fracturing operations in the United States in relation to groundwater contamination, withdrawals of freshwater resources, and jurisdictional authority over the activity with the purpose of producing objective analysis of research findings. With a growing population and increasing energy needs, hydraulic fracturing is expanding across the nation, as is public concern over the risks to freshwater resources. Because of the difficulty in identifying non-point sources of water pollution, a lack of legitimate water samples representing baseline conditions, and incomplete lists of chemical additives used, study results are often inconclusive as to the correlation between hydraulic fracturing ...


Lower San Luis Obispo Creek Stewardship Plan, Raven Lukehart, Daniel Bohlman Jun 2013

Lower San Luis Obispo Creek Stewardship Plan, Raven Lukehart, Daniel Bohlman

Natural Resources Management and Environmental Sciences

No abstract provided.


Mechanism Of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment, Dan Secor May 2013

Mechanism Of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment, Dan Secor

Electronic Thesis and Dissertation Repository

Sepsis is a systemic inflammatory response to an infection. The overwhelming inflammation has many deleterious effects, including cessation of capillary blood flow. This cessation may lead to organ failure and subsequent death, but the cause of cessation during sepsis is not fully understood. Ascorbate (reduced vitamin C) has been shown to restore capillary blood flow by an unknown mechanism. I hypothesized that activation of both platelets and the coagulation pathway in sepsis contributes to the cessation of capillary blood flow and that ascorbate protects against cessation by reducing platelet activation.

Using intravital microscopy in the mouse hindlimb skeletal muscle in ...


Sinusoidal Endothelial Cell-Derived Extracellular Matrix Regulates Basal And Stimulated Macrophage Activation., Lauren G. Poole May 2013

Sinusoidal Endothelial Cell-Derived Extracellular Matrix Regulates Basal And Stimulated Macrophage Activation., Lauren G. Poole

College of Arts & Sciences Senior Honors Theses

Fatty liver disease, be it from alcohol (ALD), obesity (NAFLD) or other sources (e.g. viral infection), share similar mechanisms of disease progression. One potential mechanism is that altered sinusoidal endothelial cell (SEC) extracellular matrix (ECM) favors a more inflammatory phenotype in resident macrophages (i.e., Kupffer cells). Here, the hypothesis was tested that SEC-derived matrices directly affect the inflammatory response of macrophages. Methods. Transformed sinusoidal endothelial cells (TSECs) were cultured for 24 or 72 hours. Culture plates were then washed with a solution that selectively removed the cells, but preserved the ECM. Cultured macrophages (RAW 264.7 cells) were ...


Evaluation Of Colloidal Stability And Ecotoxicity Of Metal-Based Nanoparticles In The Aquatic And Terrestrial Systems, Lok R. Pokhrel May 2013

Evaluation Of Colloidal Stability And Ecotoxicity Of Metal-Based Nanoparticles In The Aquatic And Terrestrial Systems, Lok R. Pokhrel

Electronic Theses and Dissertations

Intrinsic to the many nano-enabled products are atomic-size multifunctional engineered nanomaterials, which upon release contaminate the environments, raising considerable health and safety concerns. This Ph.D. dissertation is designed to investigate (i) whether metals or oxide nanoparticles are more toxic than ions, and if MetPLATETM bioassay is applicable as a rapid nanotoxicity screening tool; (ii) how variable water chemistry (dissolved organic carbon (DOC), pH, and hardness) and organic compounds (cysteine, humic acid, and trolox) modulate colloidal stability, ion release, and aquatic toxicity of silver nanoparticles (AgNP); and (iii) the developmental responses of crop plants exposed to Ag- or ZnO- ...


Design, Synthesis And Development Of Transporter Targeting Agents For Image-Guided Therapy And Drug Delivery, Ning Tsao May 2013

Design, Synthesis And Development Of Transporter Targeting Agents For Image-Guided Therapy And Drug Delivery, Ning Tsao

UT GSBS Dissertations and Theses (Open Access)

The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents, N4-guanine (N4amG) and glycopeptide (GP) were synthesized for tumor cell proliferation assessment and cancer theranostic platform, respectively. N4amG and GP were synthesized and radiolabeled with 99mTc and 68Ga. The chemical and radiochemical purities as well as radiochemical stabilities of radiolabeled N4amG and GP were tested. In vitro stability assessment showed both 99mTc-N4amG and 99mTc-GP were stable up to 6 hours, whereas 68Ga-GP was stable up to 2 hours. Cell culture studies ...


The Role Of Mitochondrial Restructuring In Neuronal Calcium Homeostasis And Excitotoxicity, Patrick Ryan Houlihan May 2013

The Role Of Mitochondrial Restructuring In Neuronal Calcium Homeostasis And Excitotoxicity, Patrick Ryan Houlihan

Theses and Dissertations

Mitochondrial Ca2+ buffering is an important physiological modulator of neuronal signaling and bioenergetics, but this propensity toward Ca2+ regulation proves pathological during excitotoxic insult. Specifically, excessive mitochondrial Ca2+ uptake is a key component of glutamate toxicity within the penumbra surrounding the ischemic core following stroke. This mitochondrial toxicity and Ca2+ dyshomeostasis may be visualized in real time as delayed calcium deregulation (DCD). DCD is a predictor of neuronal, excitoxic death, and is composed of three phases: 1) an initial response; 2) a latent period of elevated, but stable cytosolic Ca2+; and 3) failure of mitochondrial Ca2+ retention, termed deregulation. The ...


Discoveries On The Storage Of Red Blood Cells And The Exposure Of Cells In Culture To Xenobiotics, Thomas Joost Van 'T Erve May 2013

Discoveries On The Storage Of Red Blood Cells And The Exposure Of Cells In Culture To Xenobiotics, Thomas Joost Van 'T Erve

Theses and Dissertations

New medical treatments, compounds that affect human health, nutritional supplements, and other substances, are introduced to society every day. The accurate determination of the potential toxicity from these substances is of critical importance to our society. Goals of the modern toxicologist not only involve the determination of the toxic potential of new substances but also: the elucidation of mechanisms; improving existing assays; and developing new assays to study toxicity. This thesis addresses these goals in two topics fundamental to toxicology. Re-evaluating the expression of dose and susceptibility of cells in culture The exposure of cells in culture to drugs, xenobiotics ...


Modulation Of Trpv1, Nociceptor Sensitization , And Induction Of Thermal Hyperalgesia By C-Type Natriuretic Peptide, Lipin Loo May 2013

Modulation Of Trpv1, Nociceptor Sensitization , And Induction Of Thermal Hyperalgesia By C-Type Natriuretic Peptide, Lipin Loo

Theses and Dissertations

Rheumatoid arthritis (RA) is caused by aberrant attack of the joints by native inflammatory system. This can lead to joint destruction and pain that can be debilitating. Increased angiogenesis and innervation by nociceptive afferent fibers are characteristic features of RA joints, which in addition to the elevated levels of a wide variety of inflammatory mediators, are thought to play an important role in the pathogenesis of chronic inflammatory pain associated with RA. Interestingly, a recent report indicates that C–type natriuretic peptide (CNP) is increased in the blood serum of RA patients. Natriuretic peptides (NPs) control natriuresis and normalize changes ...


Distribution, Elimination And Toxicity Assessment Of Semi-Volatile Polychlorobiphenyls After Inhalation Exposure, Xin Hu May 2013

Distribution, Elimination And Toxicity Assessment Of Semi-Volatile Polychlorobiphenyls After Inhalation Exposure, Xin Hu

Theses and Dissertations

Inhalation exposure to semi-volatile polychlorobiphenyls (PCBs) that ubiquitously exist in the environment has the potential to cause adverse health effects. Recently identified sources of airborne PCBs, especially non-legacy sources, stress the importance of risk assessment for inhalation exposure. However, the fate of inhaled airborne PCBs in biological systems and the resultant toxicity remain unexplored.

The objective of this thesis research was to investigate the distribution and elimination of semi-volatile PCBs in biological systems after inhalation exposure and evaluate the biologic and toxicologic consequences. This objective was achieved by conducting the following inhalation studies in rats: a short-term exposure study of ...


Catalase Attenuates Pulmonary Fibrosis While Increasing Pro-Inflammatory Cytokines, Lei Shi May 2013

Catalase Attenuates Pulmonary Fibrosis While Increasing Pro-Inflammatory Cytokines, Lei Shi

Theses and Dissertations

Pulmonary fibrosis is an aberrant transformation of injured lung tissue. It is characterized by irreversible accumulation of extracellular matrix produced by fibroblasts and myofibroblasts during tissue remodeling, resulting in destruction and dysfunction of the lung. Asbestos is an important cause of pulmonary fibrosis. In response to asbestos exposure, alveolar macrophages and recruited monocytes generate reactive oxygen species (ROS), especially hydrogen peroxide (H2O2), pro-inflammatory cytokines, such as TNF-á and IL-1â, and induce subsequent collagen deposition in the lung. We have found that increased H2O2 levels are linked to the development of pulmonary fibrosis. Catalase converts H2O2 into water and oxygen, so ...


The Role Of Sirtuin3 In Regulating Mitochondrial Superoxide Metabolism In Response To Ionizing Radiation In Mouse Embryonic Fibroblasts., Kranti Ashok Mapuskar May 2013

The Role Of Sirtuin3 In Regulating Mitochondrial Superoxide Metabolism In Response To Ionizing Radiation In Mouse Embryonic Fibroblasts., Kranti Ashok Mapuskar

Theses and Dissertations

Exposure of mammalian cells to ionizing radiation is believed to affect mitochondrial metabolism, which can lead to increased levels of superoxide (O2*-). Sirtuin3 (Sirt3) is a key mitochondrial protein deacetylase thought to play a significant role in the maintenance of mitochondrial integrity and oxidative metabolism in response to radiation. Here I show evidence that Sirtuin3 regulates mitochondrial oxidative metabolism in unirradiated mouse embryonic fibroblasts (MEFs) as well as regulates survival and steady-state levels of O2*- following exposure to radiation. This work also identifies novel, small molecule, superoxide dismutase mimetics as being capable of ameliorating the alterations in mitochondrial ...


Modeling Greenhouse Gas Emissions And Net Return Implications For Cow-Calf Producers In The Ozark Highlands, Stephen Aaron Smith May 2013

Modeling Greenhouse Gas Emissions And Net Return Implications For Cow-Calf Producers In The Ozark Highlands, Stephen Aaron Smith

Theses and Dissertations

Cow-calf producers in the Ozark Highlands region are under continuous pressure to improve economic efficiency. Additionally, estimating greenhouse gas (GHG) emissions from cow-calf and forage production processes may become increasingly important as policy makers seek to mitigate or reduce agriculture's role in climate change. As such, this analysis had three objectives. Objective 1: Provide a model that could be used by cow-calf producers, extension agents, and researchers to evaluate GHG and net return (NR) repercussions when modifying site characteristics, production methods, and inputs. Objective 2: Develop a user guide such that the methodology for estimating cow-calf GHG emissions and ...


Modulation Of Synaptic Transmission By Adenosine In Layer 2/3 Of The Rat Visual Cortex In Vitro, Nicholas M. Bannon Apr 2013

Modulation Of Synaptic Transmission By Adenosine In Layer 2/3 Of The Rat Visual Cortex In Vitro, Nicholas M. Bannon

Master's Theses

No abstract provided.


Cultivating Resistance: Food Justice In The Criminal Justice System, Caitlin M. Watkins Apr 2013

Cultivating Resistance: Food Justice In The Criminal Justice System, Caitlin M. Watkins

Pitzer Senior Theses

This Senior Thesis in Environmental Analysis seeks to explore the ways in which certain food-oriented programs for incarcerated women and women on parole critically resist the Prison Industrial Complex and the Industrial Food System by securing social and ecological equity through the acquisition of food justice. It focuses on three case studies: the Crossroads’ Meatless Mondays program, Fallen Fruit from Rising Women: A Crossroads Social Enterprise, and Cultivating Dreams Prison Garden Project: An Organic Garden for Women in Prison. Each project utilizes food as a tool to build community, provide valuable skill sets of cooking and gardening, and educate women ...


Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins, Min Shen Jan 2013

Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins, Min Shen

Wayne State University Dissertations

Although considerable progress has been achieved in the field of cancer therapeutics, primary or acquired drug resistance remains a fundamental cause of therapeutic failure in cancer therapy. Among different mechanisms characterized that are responsible for tumor drug resistance, there is increasing evidence suggesting that dysregulation of gene expression, especially oncogene or tumor suppressor gene expression, at either gene transcription or protein synthesis level, can contribute to the drug-resistant phenotype. AMP-activated protein kinase (AMPK) is a well-known major cellular energy sensor, which negatively regulates metabolic pathways such as protein synthesis, fatty acid oxidation and glucose consumption. Activation of AMPK may suppress ...


Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell, Abiy Mussa Mohammed Jan 2013

Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell, Abiy Mussa Mohammed

Wayne State University Dissertations

MECHANISMS OF CYTOKINE-INDUCED METABOLIC DYSFUNCTION OF THE PANCREATIC BETA-CELL

by

ABIY MUSSA MOHAMMED

August 2013

Advisor: Dr. Anjaneyulu Kowluru

Major: Pharmaceutical Sciences

Degree: Doctor of Philosophy

Type I diabetes is characterized by an absolute insulin deficiency due to loss of pancreatic â-cell mass by autoimmune aggression. During the progression of the disease proinflammatory cytokines such as IL-1â, TNFá and INFã are secreted by infiltrated and activated T-cells and macrophages which ultimately damage the pancreatic â-cell. However, the signaling mechanisms involved in cytokine-induced damage are only partially understood. Phagocyte-like NADPH oxidase [NOX2] has been shown to play regulatory roles in the ...


Oligospermines For Non-Viral Sirna Delivery, Maha Elsayed Jan 2013

Oligospermines For Non-Viral Sirna Delivery, Maha Elsayed

Wayne State University Theses

In this thesis, delivery systems for siRNA delivery are introduced with special attention to non-viral vectors. Many successful vectors used in vivo were reviewed. Our work focused on the effect of different architectures of oligospermine polmers on their suitability for siRNA delivery in lung cancer cells. Different archituctures showed different polyplex structures and variable transfection efficiencies. Moreover, we presented a review on nanoimprint lithography techniques with an outlook on possible biological applications in the field of gene and drug delivery.


The Effect Of Alpha-Cyclodextrin On Acute Blood Lipid And Glycemic Responses To A Fat Containg Meal, Evan Neil Fletcher Jan 2013

The Effect Of Alpha-Cyclodextrin On Acute Blood Lipid And Glycemic Responses To A Fat Containg Meal, Evan Neil Fletcher

Wayne State University Theses

Obesity and hyperlipidemia have become major concerns in the United States over the past 30 years. Alpha-Cyclodextrin (á-CD), a naturally occurring soluble dietary fiber, has been shown to reduce dietary fat absorption and improve blood lipid levels in an animal model (mouse and rat) and in human studies. In the current double blind study, 34 healthy male and female participants were recruited to test if á-CD had any acute effect on blood lipid and glycemic responses to a fat containing meal. The participants received the á-CD on one occasion and a placebo the other to determine if there was any ...