Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

PDF

Theses/Dissertations

2013

Human and Clinical Nutrition

Institution
Keyword
Publication

Articles 1 - 25 of 25

Full-Text Articles in Life Sciences

Effect Of Functional Starch In Brown Rice And Grain Sorghum On Plasma Glucose And Insulin Responses In Humans, Nicole Marie Poquette Dec 2013

Effect Of Functional Starch In Brown Rice And Grain Sorghum On Plasma Glucose And Insulin Responses In Humans, Nicole Marie Poquette

Theses and Dissertations

Diabetes and obesity are chronic illnesses increasing at dramatic rates in the U.S. and around the world. Research has looked to prevent or control diabetes and obesity through functional ingredients such as healthy-dietary carbohydrates to control blood glucose levels. Starch is a principle carbohydrate, which influences blood glucose levels, and measuring starch digestibility fractions can help predict the glucose response in the body. The objectives of this study were to investigate the functional starch content of parboiled brown rice flour and grain sorghum flour, and measure the effects on postprandial plasma glucose and insulin levels of 14 and 10 ...


The Effect Of Wild Blueberry Consumption On The Inflammatory Response, Oxidative Stress And Dna Damage Associated With Exercise, Taylor K. Bloedon Dec 2013

The Effect Of Wild Blueberry Consumption On The Inflammatory Response, Oxidative Stress And Dna Damage Associated With Exercise, Taylor K. Bloedon

Electronic Theses and Dissertations

At all levels of intensity and duration, exercise is known to cause an increase in the generation of reactive oxygen species (ROS). When derivatives of oxygen occur and exist independently with one or more unpaired electrons they are known as “free radicals” (Halliwell and Gutteridge 2007). Since atoms possess electrons that are usually associated in pairs, free radicals have the potential to act negatively in the body. Reactive oxygen species refer to oxygen-centered radicals as well as nonradical but reactive derivatives of oxygen (Halliwell and Gutteridge 2007). When ROS are created in excess, resulting in the disruption of the pro-oxidant ...


Vitamin D Status And Bone Mineral Density In Triathletes, Michelle Konstantarakis Dec 2013

Vitamin D Status And Bone Mineral Density In Triathletes, Michelle Konstantarakis

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: The purposes of this study were first to assess the vitamin D status and bone mineral density (BMD) in male and triathletes (N=15), female triathletes (N=13), and non-athletes (N=14), and to determine if circulating vitamin D was correlated with body composition, BMD, dietary calcium and vitamin D intake in triathletes. The second purpose was to determine if triathletes have a different level of serum vitamin D, body composition, BMD, dietary calcium and vitamin D intake then non-athletes. The third purpose was to determine if BMD was correlated with body composition (body mass, percent body fat, BMI ...


Evaluation Of The Relationship Between Nutrition Knowledge And Disordered Eating Risk In Female Collegiate Athletes, Amy L. Miracle Dec 2013

Evaluation Of The Relationship Between Nutrition Knowledge And Disordered Eating Risk In Female Collegiate Athletes, Amy L. Miracle

UNLV Theses, Dissertations, Professional Papers, and Capstones

Involvement in collegiate sports among female athletes is at an all-time high with approximately 198,000 currently participating, (National Collegiate Athletic Association, 2012). With this increase in female participation in collegiate sports, the pressures of sport participation and academics lead some women to engage in harmful eating behaviors. These harmful eating behaviors may lead to the development of disordered eating (C. Johnson, Powers, & Dick, 1999; Quatromoni, 2008; Reel, SooHoo, Petrie, Greenleaf, & Carter, 2010; Reinking & Alexander, 2005). Many factors have been identified as contributing to the development of disordered eating but nutrition knowledge or lack thereof, has yet to be fully investigated as a potential risk factor. Female collegiate athletes may be at significant risk for disordered eating and identification of nutrition knowledge as a risk factor will aid in development of prevention and treatment interventions (Abood, Black, & Birnbaum, 2004; Schwitzer, Bergholz, Dore, & Salimi, 1998; Torres-McGehee et al., 2011). Limited information exists pertaining to the relationship between nutrition knowledge and disordered eating risk among female athletes in general (Raymond-Barker, Petroczi, & Quested, 2007) and none exists specifically for female collegiate athletes. The objective of this investigation is to determine if a relationship exists between sports nutrition knowledge and eating disorder risk in female collegiate athletes.

This research study sought to describe the correlational relationship between the variables of nutrition knowledge and disordered eating risk using the assessment tools Nutrition Knowledge & Screening (NKS) questionnaire and Female Athlete Screening Tool (FAST) questionnaire. Two hundred four female collegiate athletes completed the two questionnaires. Demographic, questionnaires and statistical data were analyzed.

The mean NKS score for all athletes was 19.2/31 (62% correct). The mean FAST score for all athletes was 59.5 which indicate that, overall, female collegiate athletes were asymptomatic. However, 19 athletes' scores classify them as having subclinical symptoms of eating disorders. Correlation analysis of NKS and FAST scores showed no correlation r (202) = -.014; p = .56 ...


Vitamin And Mineral Intake Relative To The Dris In Young Adults, Samantha M. Coogan Dec 2013

Vitamin And Mineral Intake Relative To The Dris In Young Adults, Samantha M. Coogan

UNLV Theses, Dissertations, Professional Papers, and Capstones

INTRODUCTION: In general, most college-aged students live highly, and newly, independent lives. Although campuses offer wide varieties of food choices, most choices do not meet the standards set by the RDA or DRIs, per NHANES 1999-2000.

METHODS: In order to document these eating patterns, 1001 male (n=379) and female (n=622) college-aged students quantified dietary intake for three consecutive days using the food log method. Assessment reports were generated and analyzed in order to determine the percentage of the DRI in both males and females, and groups with a BMI of less than 20 and greater than 30. Tests ...


Brain Bioavailability Of Polyphenols: Implications For Delivery Of Brain Health Benefits, Tzu-Ying Chen Oct 2013

Brain Bioavailability Of Polyphenols: Implications For Delivery Of Brain Health Benefits, Tzu-Ying Chen

Open Access Dissertations

Consumption of fruits and vegetables has been associated with neuroprotection and cognitive benefits throughout the life span. These associations have sparked interest in plant-derived polyphenols as biologically active agents with potential for targeting brain benefits. However, little is known regarding the ability of the polyphenols or their metabolites from polyphenol-rich products to cross the blood-brain-barrier, and be available for biological action. Furthermore, additional insight is needed on factors affecting the absorption and brain distribution of polyphenol metabolites in vivo. To fill gap in current knowledge, this thesis will focus on the effects of diabetogenic diet and diabetic state which have ...


Natural Genetic Variation Affecting Calcium Homeostasis, Rebecca Anna Replogle Oct 2013

Natural Genetic Variation Affecting Calcium Homeostasis, Rebecca Anna Replogle

Open Access Dissertations

Calcium (Ca) is essential for multiple functions within the body including skeletal health. The level of Ca in the serum is tightly regulated. During periods of habitual low Ca intake, the body senses a decrease in serum Ca and increases renal conversion of 25 hydroxyvitamin D (25(OH)D) to 1,25 dihydroxyvitamin D (1,25(OH)2D). 1,25(OH)2D acts through the vitamin D receptor (VDR) to increase intestinal Ca absorption, renal Ca reabsorption and skeletal Ca resorption. Efficient intestinal Ca absorption, especially during periods of low Ca intake, is critical for protecting bone mass. Ca absorption ...


Exploration Of Breastfeeding Concepts Among Current And Future Parents: Results Of Questionnaires Administered To Chinese And Us University Students And To New Mothers In China, Zixin Lou Aug 2013

Exploration Of Breastfeeding Concepts Among Current And Future Parents: Results Of Questionnaires Administered To Chinese And Us University Students And To New Mothers In China, Zixin Lou

Doctoral Dissertations

The objectives were to explore breastfeeding knowledge, attitudes, and intention of future parents, and to investigate indicators and causes of perceived insufficient milk (PIM) supply among Chinese mothers. Objectives were accomplished using a cross-sectional study design. Two questionnaires were developed, one targeting Chinese and US undergraduates, and a second targeting Chinese mothers. In total, 597 undergraduates (395 Chinese; 202 US) and 392 Chinese mothers participated in the study. Data cleaning resulted in a final sample size of 572 for undergraduates (383 Chinese; 189 US) and 341 for Chinese mothers. Results showed that undergraduates in both countries possessed some breastfeeding knowledge ...


The Impact Of Parent Education On Parental Feeding Practices, Larra Kolby Brawley Aug 2013

The Impact Of Parent Education On Parental Feeding Practices, Larra Kolby Brawley

Theses and Dissertations

This research looked at the potential impact that parent education may have on the feeding practices of parents of young children. Since eating behaviors are a national concern for both children and adults, it's important to examine how we can create not just healthier children but, as a result, healthier adults. This study utilized an intervention that was an adapted version of a healthy eating curriculum created by Sesame Workshop and the California WIC association with the intention of improving parental feeding practices through a behavior-based approach. Previous research with this curriculum has addressed only low-income populations, with a ...


Exercise Participation During Weight Loss On A High Protein – Low Carbohydrate Diet Plan In Females Aged 15-25 Years, Margaret Mobley-Meulman Aug 2013

Exercise Participation During Weight Loss On A High Protein – Low Carbohydrate Diet Plan In Females Aged 15-25 Years, Margaret Mobley-Meulman

Electronic Theses and Dissertations

Weight gain due to poor diet and lack of exercise is responsible for over 300,000 deaths each year (U.S. Department of Health and Human Services, 2010). Obese adults have an increased risk for serious health conditions including high blood pressure and cholesterol, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea, respiratory problems, and certain cancers (National Cancer Institute, 2012). Participation in exercise can help control weight, strengthen muscles and bones, and reduce the incidence of cardiac events, stroke, hypertension, type 2 diabetes, colon and breast cancers, osteoporotic fractures, gallbladder disease, obesity, depression, anxiety, and ...


Associations Between Alcohol Consumption And Fasting Blood Glucose In Young Adults, Julie Ann Lucca Jun 2013

Associations Between Alcohol Consumption And Fasting Blood Glucose In Young Adults, Julie Ann Lucca

Master's Theses and Project Reports

Current research shows moderate alcohol consumption is associated with decreased risk of diabetes and excessive consumption or binge drinking can cause insulin resistance and diabetes. In 2010, diabetes was the seventh leading cause of death in the United Statesand was responsible for significant health complications: blindness, kidney failure, and limb amputations, and is a large national economic burden. Fasting blood glucose (FBG) is a tool used to help diagnose diabetes. Abnormally high FBG, ≥100 mg/dl, is indicative of diabetes and pre-diabetes. Few studies have observed diabetic prevalence among young adults or college students. Studying young adults can help provide ...


A Pilot Study Of The Efficacy And Program Cost-Effectiveness Of Prevention Plus For Childhood Obesity, Shannon Marie Looney May 2013

A Pilot Study Of The Efficacy And Program Cost-Effectiveness Of Prevention Plus For Childhood Obesity, Shannon Marie Looney

Doctoral Dissertations

Background: In 2007 an Expert Committee published recommendations using a staged approach for the treatment of childhood obesity in the primary care setting. Limited research has evaluated the efficacy of these recommendations. Thus, the primary aim of this study was to test the efficacy of Prevention Plus for the treatment of childhood overweight and obesity in a primary care setting. Cost is a major barrier to translation of research into practice thus, program cost-effectiveness was also evaluated. Methods: Twenty-two children (8.0 ± [plus-minus] 1.8 years; 2.34 ± 0.48 z-BMI; 68.2% female, 72.7% White, 90.9% non-Hispanic ...


Physio-Chemical And Sensory Properties Of A Nutrient-Fortified Extruded Product, Tajudini Lassissi Akande May 2013

Physio-Chemical And Sensory Properties Of A Nutrient-Fortified Extruded Product, Tajudini Lassissi Akande

Theses and Dissertations

Protein malnutrition is responsible for half the deaths of children under the age of five each year in developing countries. More than 4%, 26%, and 70% of children with protein malnutrition live in Latin America/the Caribbean, Africa, and Asia, respectively. The objective of this research was to develop a novel snack made with millet, black eye bean (from Niger Republic), and rice flour fortified with soybean meal protein using extrusion technology. Proximate analysis of the four flours was carried out to determine their chemical composition. Central composite design (CCD) was used to obtain best extrusion conditions to develop a ...


Mitigation Strategies To Ameliorate Acute And Chronic Heat Stress Utilizing Supplemental Methionine Or Embryonic Thermal Conditioning In Chickens, Kevin Bolek Jan 2013

Mitigation Strategies To Ameliorate Acute And Chronic Heat Stress Utilizing Supplemental Methionine Or Embryonic Thermal Conditioning In Chickens, Kevin Bolek

Graduate Theses and Dissertations

Experiments were conducted exploring potential strategies to mitigate the negative effects of heat stress in chickens. In the first experiment, broilers were placed in environments which were heat treated (HT), thermoneutral (TN), or thermo-neutral coupled with pair-feeding (TN-PF). Birds were fed diets containing either DL-methionine (DLM) or 2-hydroxy-4-methylthiobutanoic acid (HMTBA) formulated to adequate or super-adequate levels of digestible sulfur amino acids (DSAA). Reduced (GSH), oxidized (GSSG), and total (TGSH) glutathione as well glutathione peroxidase (GPx) activity were measured to assess antioxidant capacity. Thiobarbituric acid reactive substances (TBARS) were measured to assess lipid peroxidation. Several blood variables were also measured. Responses ...


Associations Between Vitamin D Status And Blood Lipid Parameters In Healthy, Older Adults, Felicia L. Steger Jan 2013

Associations Between Vitamin D Status And Blood Lipid Parameters In Healthy, Older Adults, Felicia L. Steger

Graduate Theses and Dissertations

Background. One explanation for the relationship between vitamin D and cardiovascular disease (CVD) mortality could be related to altered serum lipids. This study aimed to determine the association between 25OHD and serum lipid concentrations in healthy, older adults.

Methods. Serum lipid panels and 25OHD concentrations were obtained on 190 adults (median age 67 years) after a 12-hour overnight fast. 25OHD was measured by the DiaSorin Liason system. Subjects were stratified by 25OHD concentrations: <20.0 ng/mL, 20.0-29.9 ng/mL, 30.0-39.9 ng/mL and ≥40 ng/mL. One-way ANOVA was used to observe unadjusted differences and Student's t-tests were used to determine differences between groups. Multiple regression analyses were performed to determine the ability of 25OHD to predict serum lipid concentrations when accounting for BMI, sex, age, and statin use. Stepwise regression analyses were used to establish the best prediction model for each outcome.

Results. There was a significant relationship between 25OHD and BMI (p<0.001), glucose (p=0.042), TG (p=0.020), TC (p<0.001), LDL (p<0.001) and the TC:HDL ratio (p<0.001), but not for blood pressure, HDL, or TG:HDL ratio. When comparing subjects with 25OHD ≥40.0 ng/mL to those with <20 ng/mL, those in the highest group had a significantly lower BMI (26.1 0.7 and 29.9 0.8 kg/m2), TG (100.9 7.8 and 130.4 9.5 mg/dL), TC (182.7 5.2 and 217.4 6.3 mg/dL), LDL (100.3 4.5 and 131.2 5.4 mg/dL), and calcium (9.67 0.05 and 9.50 0.06 mg/dL) concentrations, and had significantly lower TC:HDL (3.09 0.15 and 4.15 0.08) and TG:HDL (1.79 0.22 and 2.56 0.27) ratios.

When adjusting for confounders, the relationship between 25OHD and TC (p<0.001) and LDL (p<0.001) remained significant, but that between TC:HDL and TG:HDL did not. When a stepwise regression analysis was performed to determine the best model for predicting serum lipid parameters, each 10 ng/mL increase in 25OHD predicted a statistically significant 6.72 mg/dL decline in TC (p<0.001) and 5.55 mg/dL decline in LDL (p<0.001).

Conclusions. 25OHD status is associated ...


Regulation Of Intestinal Innate Immunity By Dietary Vitamin A, Sean Paul Spencer Jan 2013

Regulation Of Intestinal Innate Immunity By Dietary Vitamin A, Sean Paul Spencer

Publicly Accessible Penn Dissertations

The gastrointestinal tract has evolved in the context of continuous exposure to both commensal organisms as well as dietary intake. While the impact of commensal organisms on the immune system has been well studied, the effects of dietary factors in the control of intestinal immunity remain unclear. Moreover, the immunologic effects of vitamin deficiencies and are poorly understood. Using a mouse model of dietary vitamin A deficiency, we investigated mechanisms by which the principle vitamin A metabolite, retinoic acid, regulates several aspects of innate immunity. In Chapter 1 we present the hypothesis that the homeostasis of innate cells in the ...


Obesity And Adipose Tissue Expansion In Ossabaw Swine, Richard Joel Faris Jan 2013

Obesity And Adipose Tissue Expansion In Ossabaw Swine, Richard Joel Faris

Graduate Theses and Dissertations

Obesity is characterized as a state of chronic low-grade inflammation, which originates in adipose tissue from adipocyte dysfunction as a consequence of adipocyte hypertrophy. Although rodent models have been pivotal to understanding the etiology of obesity and its co-morbidities, and the roles of specific genes, distinct differences between rodents and humans underscore the need for alternative comparative models. Swine are an attractive comparative model because of similar physiology and anatomy with humans. Ossabaw swine are of particular interest due to their "thrifty" genotype and predisposition to multiple risk factors for the metabolic syndrome.

Saturated fatty acids have the distinct ability ...


Early Prevention Of Childhood Obesity: Impact Of Maternal Physical Activity On Pregnancy And Child Outcomes, Kai Ling Kong Jan 2013

Early Prevention Of Childhood Obesity: Impact Of Maternal Physical Activity On Pregnancy And Child Outcomes, Kai Ling Kong

Graduate Theses and Dissertations

Maternal obesity and excessive gestational weight gain cause a perpetuating "vicious cycle" of obesity, where obese women or women who gain excess gestational weight have a higher risk of giving birth to large for gestational age infants, who then, years later, can become obese adults entering into their own pregnancies. Many observational studies have supported the role of physical activity (PA) in helping pregnant women to minimize, if not prevent, excessive gestational weight gain (GWG). Since maternal PA has potential to prevent excessive GWG and decrease the risk for delivering large-for-gestational-age (LGA) infants, identifying strategies to help pregnant women increase ...


Blossom Project 2: Longitudinal Assessment Of Physical Activity, Sedentary Behavior, Diet Quality, And Weight Gain During Pregnancy, Diana Rose Di Fabio Jan 2013

Blossom Project 2: Longitudinal Assessment Of Physical Activity, Sedentary Behavior, Diet Quality, And Weight Gain During Pregnancy, Diana Rose Di Fabio

Graduate Theses and Dissertations

The benefits of physical activity (PA) during pregnancy have been well documented, but little is known about the contribution of activity sub-components including sleep, sedentary, light, moderate, and vigorous activity on gestational weight gain (GWG). Additionally, the relationship between diet quality and GWG has yet to be determined. A prospective, longitudinal study was conducted during 2nd and 3rd trimester to objectively quantify and identify modifiable aspects of total PA including sleep, sedentary, light, moderate, and vigorous activity, and dietary intake. Participants (n=46) wore a SenseWear Armband and an activPALTM activity monitor for seven consecutive days during which a ...


Characterization Of The Effects Of Intestinal Physiology Modified By Exogenous Enzymes And Direct-Fed Microbial On Intestinal Integrity, Energy Metabolism, Body Composition And Performance Of Laying Hens And Broiler Chickens, Ganapathi Raj Murugesan Jan 2013

Characterization Of The Effects Of Intestinal Physiology Modified By Exogenous Enzymes And Direct-Fed Microbial On Intestinal Integrity, Energy Metabolism, Body Composition And Performance Of Laying Hens And Broiler Chickens, Ganapathi Raj Murugesan

Graduate Theses and Dissertations

The objective of this dissertation was to evaluate the effects of exogenous enzymes (EE) and direct-fed microbial (DFM) supplementation on bird intestinal integrity, energy metabolism, body composition and performance of laying hens and broiler chickens. The effects of reduced dietary metabolizable energy (ME) on performance, intestinal integrity and body composition of laying hens were evaluated in two experiments. A reduction of 90 kcal/kg of dietary ME over a period of 12 weeks did not significantly alter performance or nitrogen corrected apparent ME (AMEn), but reduced abdominal fat pad. In the follow-up experiment, no significant differences were noted in performance ...


The Mediating Role Of Dietary Patterns On The Relation Between Acculturation, Psychosocial Factors, And Cardiovascular Disease Risk Factors In The U.S. - Mexico Border, Ximena Burgos Jan 2013

The Mediating Role Of Dietary Patterns On The Relation Between Acculturation, Psychosocial Factors, And Cardiovascular Disease Risk Factors In The U.S. - Mexico Border, Ximena Burgos

Open Access Theses & Dissertations

Chronic diseases affect both, developed and developing countries around the world. In the U.S., cardiovascular diseases (CVD) are the leading cause of death for all groups including Hispanics (Heron, 2009). Hispanics are disproportionally affected by CVD and experience risk factors at higher rates than non-Hispanic whites (Swenson, 2002). Although CVD are among the most expensive and widespread health problems, they are among the most preventable. Evidence shows that diet plays a very important role in the development of chronic diseases; current dietary changes are partially responsible for the increasing epidemic of chronic diseases worldwide. It is well established that ...


Disordered Eating Habits And Behaviors Among Elite Collegiate Athletes, Ann M. Armes Jan 2013

Disordered Eating Habits And Behaviors Among Elite Collegiate Athletes, Ann M. Armes

Theses and Dissertations--Dietetics and Human Nutrition

Eating disorders and disordered eating habits and behaviors were measured using the Eating Disorders Inventory-3 Referral Form (EDI-3 RF). The sample consisted of 159 elite, collegiate student athletes, males and females, aged 18 to 22. Five sports were represented, including basketball, gymnastics, soccer, swimming & diving, and volleyball. Overall, findings support the position that athletes, as a distinct population, and specifically female athletes and those that participate in lean sports, are at an increased risk for disordered eating behaviors and diagnosable eating disorders. Of the 159 total athletes that completed the questionnaire, 33% (n=53) of the athletes sampled met one ...


Iron Bioavailability And Consumer Acceptability Of Extruded Common Bean (Phaseolus Vulgaris) Flour, Martin Mutambuka Jan 2013

Iron Bioavailability And Consumer Acceptability Of Extruded Common Bean (Phaseolus Vulgaris) Flour, Martin Mutambuka

Graduate Theses and Dissertations

Iron deficiency anemia continues to be a major nutritional challenge worldwide and is mainly caused by dependence on staple foods which are low in iron bioavailability. In many parts of the world, the common bean (Phaseolus vulgaris) is an important source of iron. Bean iron has very low bioavailability and household/industrial processing technologies have been shown to improve iron bioavailability. In this study, iron bioavailability of 16 Ugandan bean varieties was determined using an in vitro digestion/Caco-2 cell culture model and modeled with respect to key influencing factors; phytate, polyphenol, ferritin and iron content. The effect of extrusion ...


Oral S-Adenosyl Methionine (Sam) Mediates Disruptions In Methyl Group Metabolism Due To Retinoic Acid Therapy And Alters Neurotransmitter Metabolism: Implications For Major Depressive Disorder, Anne Smazal Jan 2013

Oral S-Adenosyl Methionine (Sam) Mediates Disruptions In Methyl Group Metabolism Due To Retinoic Acid Therapy And Alters Neurotransmitter Metabolism: Implications For Major Depressive Disorder, Anne Smazal

Graduate Theses and Dissertations

Disruptions in methyl group metabolism have been associated with a number of disease states, including birth defects, cardiovascular disease, and neurological disorders. Therefore, characterization of the factors that regulate folate and methyl group supply is essential for the development of disease treatments and prevention. Glycine N-methyltransferase (GNMT), an enzyme essential to methyl group balance, is markedly increased by retinoic acid treatment. Furthermore, retinoid therapy has been shown to impact neurotransmitter metabolism, thereby contributing to the development of major depressive disorder. Recently, it has been shown that depressed patients have low levels of folate, other B-vitamins, and s-adenosylmethionine (SAM), all compounds ...


Impact Of High Calcium Intake From Calcium Carbonate Or Dairy On Cardiovascular Function, Coronary Artery Calcification And Coronary Artery Disease Burden In Ossabaw Miniature Swine, Alyssa K. Phillips Jan 2013

Impact Of High Calcium Intake From Calcium Carbonate Or Dairy On Cardiovascular Function, Coronary Artery Calcification And Coronary Artery Disease Burden In Ossabaw Miniature Swine, Alyssa K. Phillips

Open Access Theses

Recent secondary analyses have associated supplemental calcium use with increased risk for myocardial infarction and cardiovascular-related death in healthy, older adults. Subsequent concern over the safety of calcium supplements has spurred a calcium controversy, because calcium is a shortfall essential nutrient that is critical for bone health and a mainstay of osteoporosis prevention and treatment. The proposed mechanism by which calcium intake may detriment cardiovascular health is through the acceleration of coronary artery calcification (CAC), a clinical indicator of coronary artery disease (CAD) that has been associated with mortality risk. However, causal evidence to support this hypothesis is lacking. Determining ...