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Full-Text Articles in Life Sciences
Developmental Expression Profile Of Bric Á Brac 2, Midline And H15 In The Developing Eye And Central Nervous System Of Drosophila Melanogaster, Petra Visic
Aberrant activity of a single gene can lead towards development of cancerous cells. Drosophila melanogaster is a useful model system to study cancer because there is high degree of evolutionary conservation in signaling pathways between humans and flies that play major roles in regulating cell proliferation and growth (Miles et al., 2011). At The University of Southern Mississippi (USM), Dr. Leal’s lab has gathered evidence suggesting that bab1 and bab2 interact with the T-box gene midline (mid) and its paralog H15, while the early developmental function of bab1 and bab2 remains unknown. That is why elucidating the early interactions ...
Elucidating The Role Of Apoptosis During Cyclical Body Regeneration In Botryllus Schlosseri, Meredith Adamo
Apoptosis is the principal form of programmed cell death by which multicellular animals rid themselves of old cells in order to allow new cells to grow. The colonial ascidian Botryllus schlosseri is a model system for homeostatic cell death and regeneration. During its unique, weekly budding cycle known as blastogenesis, new buds are produced asexually and eventually replace the old adult zooid generation through resorption via circulating phagocytes. Using polyester wax-embedded tissue sections, we have shown that TUNEL-positive (terminal deoxynucleotidyl transferase nick end-labeling), apoptotic cells are observed within circulating phagocytes in all stages of the colony’s death phase (takeover ...
Using Spheroids And A Bioluminescent Mouse Model To Determine The Effects Of Ajulemic Acid On Ewing's Scarcoma, Drake Hardy
Ewing's Sarcoma is a pediatric bone cancer with a five-year survival rate of only 30%. New treatment options for this highly aggressive disease are desperately needed. Ajulemic acid (AJA), a synthetic cannabinoid, has been the focus of our research, and has demonstratedd the ability to decrease tumor cell viability and inhibit endothelial cell migration and angiogenesis. Based on these results, AJA is a potential therapeutic agent for Ewing's Sarcoma and other solid pediatric cancers. In order to create a realistic environment in vitro in which to study these tumors, we created 3-dimensional spheroids with three cell types, each ...