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Full-Text Articles in Life Sciences

The Role Of Oxidative Stress In The Pathogenesis Of Epithelial Ovarian Cancer, Nicole Marie King Jan 2013

The Role Of Oxidative Stress In The Pathogenesis Of Epithelial Ovarian Cancer, Nicole Marie King

Wayne State University Dissertations

Ovarian cancer is the leading cause of death from gynecologic malignancies yet the underlying pathophysiology is not clearly established. The disease is usually diagnosed in the advanced stage and carries a poor prognosis. The 5-year survival rate is greater than 75% if diagnosis of the cancer occurs at an early stage; however, this rate drops to 20% when the tumor has spread beyond its origin. Thus, a method for early detection is critically needed, which can help prolong, or even save lives. Currently, an effective screening test for ovarian cancer is lacking. Many tests have been evaluated but have been ...


An Investigation Into The Role Of Cfia 3' End Processing Complex In The Termination And Initiation/Reinitiation Of Transcription, Nadra Al-Husini Jan 2013

An Investigation Into The Role Of Cfia 3' End Processing Complex In The Termination And Initiation/Reinitiation Of Transcription, Nadra Al-Husini

Wayne State University Dissertations

In budding yeast, as in higher eukaryotes, transcription of protein coding genes is executed by a highly specialized, conserved polymerase called RNA polymerase II (RNAPII). The transcription cycle of RNAPII has four major steps: initiation, elongation, termination, and reinitiation. The successful accomplishment of each of these steps requires a number of accessory factors. Many of these factors operate at multiple steps in the transcription cycle. The major focus of this study was to examine the function of Clp1, which is an RNA processing factor operating at the 3′ end of genes, in the transcription cycle. Clp1 is one of the ...


Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation, Marina Victoria Bakhmutsky Jan 2013

Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation, Marina Victoria Bakhmutsky

Wayne State University Dissertations

Chapters 2 and 3:

Depleted Uranium (DU) is a high-density heavy metal that has been used in munitions since the 1991 Gulf War. DU is weakly radioactive and chemically toxic and long term exposure may cause adverse health effects. This study evaluates genotoxic effects of DU exposure in Gulf War I Veterans as a function of uranium (U) body burden by measuring chromosome damage in peripheral blood lymphocytes with the cytokinesis blocked micronucleus assay (CBMN) and fluorescence in situ hybridization (FISH) whole chromosome painting. Study subjects are Gulf War I Veterans exposed to DU during friendly fire incidents in 1991 ...


Insight Into Human Brain Evolution Through Phylogenetic Analysis And Comparative Genomics, Amy Marie Boddy Jan 2013

Insight Into Human Brain Evolution Through Phylogenetic Analysis And Comparative Genomics, Amy Marie Boddy

Wayne State University Dissertations

As a species, humans are often considered to be unique among mammals, with respect to their large brain size and enhanced cognitive abilities. Humans are the most encephalized mammals, with a brain that is six times larger than expected relative to body mass. Presumably, it is this high degree of encephalization that underlies our advanced cognitive abilities, including the skills needed for complex language and culture. Understanding how large brains evolved can shed light on what makes the human brain unique and introduce possible mechanism for human specific neurodegenerative diseases. This study takes a both a phenotypic and molecular approach ...


Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity, Kelly Haagenson Jan 2013

Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity, Kelly Haagenson

Wayne State University Dissertations

ABSTRACT

EXPRESSION AND REGULATION OF MAP KINASE PHOSPHATASES 1 and 2 IN BREAST CANCER TAMOXIFEN SENSITIVITY

by

KELLY K. HAAGENSON

May 2013

Advisor: Dr. Malathy Shekhar

Co-Advisor: Dr. Gen Sheng Wu

Major: Cancer Biology

Degree: Doctor of Philosophy

The deregulation of cell signaling is a very important component in the development and progression of cancer. One group of signaling molecules that has been implicated in these processes is the Mitogen-Activated Protein Kinase (MAPK) family which consists of three major branches in mammalian cells: ERK, JNK and p38. The activity of these kinases has wide-ranging effects within the cell and must ...


Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation, Debashish Unnikrishnan Menon Jan 2013

Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation, Debashish Unnikrishnan Menon

Wayne State University Dissertations

In humans and flies, females have two X chromosomes but males have one X chromosome and one Y chromosome. This leads to a fatal imbalance in X-linked gene expression in one sex. In mammals and in the fruit fly Drosophila, modulation of X chromosome expression is critical for survival. This process is termed dosage compensation. Flies increase expression from the male X chromosome two-fold. This is achieved by the Male Specific Lethal (MSL) complex, which consists of two large, non-coding RNA on the X transcripts (roX1 and roX2) and five proteins. The roX RNAs have a critical role in complex ...