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Theses/Dissertations

2013

Biology

Utah State University

Bioactive

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Novel Aminoglycosides: Bioactive Properties And Mechanism Of Action, Sanjib K. Shrestha May 2013

Novel Aminoglycosides: Bioactive Properties And Mechanism Of Action, Sanjib K. Shrestha

All Graduate Theses and Dissertations

Fungicide discovery is relatively neglected when compared to the investment in the development of antibacterial, antiviral, and anti-cancer therapeutics. Due to extensive use of currently available fungicides in agriculture and medicine, resistance is emerging among plant and animal pathogenic fungi. This necessitates the search for novel antifungal agents that are effective and less toxic and that do not promote resistance.

FG08 and K20 are novel aminoglycoside analogs synthesized from kanamycin B and A, respectively. The antimicrobial properties of these analogs were tested in vitro against a wide range of agriculturally and clinically important fungal pathogens. Both compounds showed broad-spectrum antifungal ...