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Theses/Dissertations

1997

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Full-Text Articles in Life Sciences

Personal Characteristics Of Beginning, Intermediate, And Advanced Sport Performers, Danielle R. Chiesi Dec 1997

Personal Characteristics Of Beginning, Intermediate, And Advanced Sport Performers, Danielle R. Chiesi

Kinesiology, Sport Studies, and Physical Education Master’s Theses

This study investigated differences in six sport specific personal characteristics as a function of skill level. The characteristics included competitive trait anxiety, trait self-confidence, concentration, mental preparation skills, achievement motivation, and leadership. A self-evaluation questionnaire was administered to students in beginning, intermediate, and advanced physical education activity classes at the State University of New York, College at Brockport. Analysis of variance (ANOVA) and multiple comparison test statistics were used to analyze differences for each of the six personal characteristics and a mental toughness composite score across the three groups of performers.

The results revealed significant differences in achievement motivation in ...


Cd40-Mediated Signaling Of Interleukin-1(Beta) Synthesis And Rescue From Apoptosis In Monocytes: Modulation By Il-4 And Il-10, Jonathan C. Poe Dec 1997

Cd40-Mediated Signaling Of Interleukin-1(Beta) Synthesis And Rescue From Apoptosis In Monocytes: Modulation By Il-4 And Il-10, Jonathan C. Poe

Electronic Theses and Dissertations

To date, the cellular mechanisms involved in the progression of diseases characterized by chronic inflammation, such as rheumatoid arthritis (RA), remain largely unknown. However, cell-to-cell contact interactions between CD4+ helper T (Th) cells and monocytes have been implicated in the induction and maintenance of pro-inflammatory cytokine synthesis that is characteristic to the pathogenesis of RA. One such cytokine produced during monocyte-Th cell contact is interleukin (IL)-1 β, a mediator directly involved in the characteristic tissue destruction that occurs in the synovia of individuals with RA. Previous studies in our laboratories have shown that ligation of CD40 on monocytes with ...


Effects Of Oxidized Low Density Lipoprotein On Nitric Oxide Production In Macrophages, Annong Huang Dec 1997

Effects Of Oxidized Low Density Lipoprotein On Nitric Oxide Production In Macrophages, Annong Huang

Electronic Theses and Dissertations

The effects of oxidatively modified low density lipoprotein (oxLDL) on atherogenesis may be partly mediated by alterations in nitric oxide (NO) production by macrophages. A major goal of this study was to identify the lipid components in oxLDL modulating NO production. The effect of a water soluble antioxidants (N-acetylcysteine) and lipid soluble antioxidant (alpha-tocopherol) on NO production in macrophages was also determined. A second goal was to determine if the effects of oxLDL occurred at the transcriptional level. Human LDL was oxidized using an azo-initiator 2,2$\sp\prime$-azobis (2-amidinopropane) HCI (ABAP). OxLDL markedly decreased the production of NO ...


Comparison Of Beta-Adrenoceptor Coupled Camp Production In Cultured Human Mononuclear Leukocytes And Myometrial Cells, Yu-Li Liu Dec 1997

Comparison Of Beta-Adrenoceptor Coupled Camp Production In Cultured Human Mononuclear Leukocytes And Myometrial Cells, Yu-Li Liu

Electronic Theses and Dissertations

$\beta\sb2$-Adrenoceptor ($\beta\sb2$-AR) agonists, such as terbutaline, are used as tocolytic agents in the treatment of preterm labor. $\beta$-Adrenoceptor stimulation relaxes myometrium through specific receptors coupled through Gs to adenylyl cyclase (AC) that catalyzes the conversion of ATP to cAMP. The purpose of this study was to compare $\beta$-adrenoceptors and cAMP production in cultured human leukocytes and myometrial cells, and to determine the importance of $\beta$-adrenoceptors and cAMP production in isoproterenol-induced myometrial relaxation. $\sp{125}$I-iodopindolol was used to assess $\beta$-adrenoceptor affinity and number cAMP levels were analyzed before and after stimulation by ...


Fish Fauna Of The Upper Cumberland River Drainage In Tennessee, John T. Baxter Dec 1997

Fish Fauna Of The Upper Cumberland River Drainage In Tennessee, John T. Baxter

Masters Theses

This thesis reports the findings of an ichthyofaunal survey of the upper Cumberland River drainage in Scott, Campbell, and Claiborne counties, Tennessee. This drainage lies on the Cumberland Plateau in northeastern Tennessee and has been impacted by extensive coal mining activity in the region. Present in the drainage are five listed species of primary concern to this study, Phoxinus cumberlandensis, Ericymba buccata, Notropis rubellus rubellus, Etheostoma baileyi, and Etheostoma sagitta. An additional species found in this drainage, Etheostoma nigrum susanae, is being considered for protected status. Field work for this survey was conducted mainly during May-August 1996 and May-August 1997 ...


Caloric Production Of Black Bear Foods In Great Smoky Mountains National Park, Robert Michael Inman Dec 1997

Caloric Production Of Black Bear Foods In Great Smoky Mountains National Park, Robert Michael Inman

Masters Theses

Understanding energetic potential of habitat patches is important for management designed to provide adequate habitat for wildlife species. Great Smoky Mountains National Park (GSMNP) has a high density of black bears that have been studied intensively from 1968-1997; habitats within the Park are relatively undisturbed, and similar vegetative cover types can be found throughout the southern Appalachian mountains. Black bear reproduction in the Park has been correlated to hard mast production, however little work has been done to assess the importance of soft mast. Geographic Information System (GIS) based habitat use models have been developed for bears in the Park ...


Scanning Electron Microscopy, Histological, And Tissue Culture Studies Of Powdery Mildews Infecting Dogwoods, Leigh Ann Klein Dec 1997

Scanning Electron Microscopy, Histological, And Tissue Culture Studies Of Powdery Mildews Infecting Dogwoods, Leigh Ann Klein

Masters Theses

Powdery mildew has become a common and widespread foliar disease of dogwoods. Microsphaera pulchra Cooke and Peck, and Phyllactinia guttata (Wallr.: Fr.) Lev. are two causal agents of powdery mildew on dogwood species in eastern North America. A clear understanding of the host-pathogen relationship between these fungi and their host must be obtained to advance research in disease management and resistance breeding.

A necessary step in studying a disease is to identify the causal agent. Leaves of C. florida 'Cherokee Sunset' and C. amomum (silky dogwood) were observed under a compound microscope to determine causal agents of powdery mildew based ...


Relationships Among Food Insufficiency, Dietary Status Index, And Food Group Intake In Women Of Childbearing Age: Secondary Data Analysis Of Nhanes Iii, Mary Leigh Miller Dec 1997

Relationships Among Food Insufficiency, Dietary Status Index, And Food Group Intake In Women Of Childbearing Age: Secondary Data Analysis Of Nhanes Iii, Mary Leigh Miller

Masters Theses

(From the Introduction)

The purpose of this research was to study women of childbearing age at different levels of food sufficiency and to examine differences in relationships between food group intake and DSI. Specifically, this study attempted to determine if intake of a particular food group relates to dietary status (DSI) differently when women experience food insufficiency compared to food sufficiency. Examination of such relationships serves as a foundation for appropriate, population-specific interventions, policy-making agendas, and further surveillance efforts which affect women of childbearing age and their families. The following text is a review of current literature on which the ...


Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer Dec 1997

Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer

Pharmaceutical Sciences ETDs

Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore ...


Isolation And Characterization Of Cadmium Hypertolerant Mutants Of Arabidopsis Thaliana, Santiago Xavier Navarro Dec 1997

Isolation And Characterization Of Cadmium Hypertolerant Mutants Of Arabidopsis Thaliana, Santiago Xavier Navarro

Master's Theses

Cadmium is an environmental pollutant which accumulates by deposition from anthropogenic activities. Plants readily take-up cadmium from soil and is concentrated in shoot tissues. Plant and animal systems are affected detrimentally by the exposure to cadmium and are known to produce metal binding peptides as part of detoxification mechanisms. In an attempt to find alternative methods of soil cleanup, efforts are being undertaken to isolate heavy metal accumulating plants. Alternatively, to reduce the accumulation of cadmium in food, plants that exclude heavy metals are also being sought. The objective of this project was to isolate mutants which can be used ...


The Effect Of Drying And Rewetting On Single Fiber Flexibility For Chemical And Mechanical Pulps, Mark E. Dulemba Dec 1997

The Effect Of Drying And Rewetting On Single Fiber Flexibility For Chemical And Mechanical Pulps, Mark E. Dulemba

Master's Theses

Over the years, various attempts have been made to develop methods to measure fiber flexibility. In the course of developing test methods for fiber flexibility, various studies have been performed that measure the flexibilities of different wood pulps.

In this study, never-dried individual thermomechanical pulp (TMP) and bleached kraft fibers were mounted on the tip of a glass tube submerged in water and deflected by water flow. The deflection of the individual fibers was measured using a microscope and image analysis software. The fibers were then dried, rewetted, and the deflection was measured_again. This drying and rewetting cycle was repeated ...


The Repulping Of Wet-Strength Paperboard, Angelo N. Melchiorre Dec 1997

The Repulping Of Wet-Strength Paperboard, Angelo N. Melchiorre

Master's Theses

Beverage carrier paperboard containing the polyamide wet-strength resin is one type of fiber that is presently landfilled. In this study, it was repulped at a 15% consistency and a pH of 10 at 150° F. in a z-bar mixer. Hydrogen peroxide (HP), ammonium perswulfate (AP), sodium persulfate (SP) and dimethyldioxirane (DMD) were used during repulping. The HP was added at 1.0%, 2.5% and 5.0%, based on O.D. weight of the fiber. The remaining chemicals were added at the same oxidation equivalent. During repulping, the pulp was screened using a Britt Jar to determine percent yield over ...


Effect Of Insulin And Vanadate On Sre-Mediated C-Fos Expression And Jnk Activation, Francisco J. Berguido Dec 1997

Effect Of Insulin And Vanadate On Sre-Mediated C-Fos Expression And Jnk Activation, Francisco J. Berguido

Master's Theses

Insulin mimetics are compounds that mimic the action of insulin in the body and are currently being studied as possible therapeutic agents against diabetes. Vanadium has been identified as an element with insulin-like properties with regard to metabolic processes such as lowering blood glucose levels. Few studies have implicated vanadium in mitogenic actions such as cell growth and differentiation. We studied the action of vanadate on the expression of the insulin-induced SRE, a cis-element of the well-characterized mitogenic gene c-fos. We measured this expression by means of a plasmid containing the reporter gene luciferase linked to the sequences from c-fos ...


Activation Of Signal Proteins By Insulin And Selenite In Primary Rat Hepatocytes, Ginny Lynn Garlock Dec 1997

Activation Of Signal Proteins By Insulin And Selenite In Primary Rat Hepatocytes, Ginny Lynn Garlock

Master's Theses

Insulin has a wide range of metabolic and mitogenic effects in cells. The mechanism of insulin action in controlling these events is not well understood, but involves, at least in part, a complex phosphorylation cascade. Selenate has been shown to mimic insulin on several metabolic processes, including the regulation of glucose-6-phosphate dehydrogenase (G6PDH) gene expression. Its mechanism of action, however, is not known. To investigate the mechanisms of insulin and selenate action on the regulation of G6PDH, signal proteins from primary rat hepatocytes were first studied. Insulin and sodium selenate similarly increased tyrosyl phosphorylation of the β-subunit of the insulin ...


An Examination Of The Hypothalamo-Neurohypophysial System Of The Rat: Restoration Of The Vasopressinergic System, Lynn M. Dibenedetto Dec 1997

An Examination Of The Hypothalamo-Neurohypophysial System Of The Rat: Restoration Of The Vasopressinergic System, Lynn M. Dibenedetto

GSBS Dissertations and Theses

The hypothalamo-neurohypophysial model has been studied for many years. Of note, when the axons of the magnocellular, peptidergic neurons of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) are transected or crushed, varying degrees of polydipsia and polyuria ensue as the result of measurable losses of vasopressin (AVP) within the organism's circulation. Following insult, these hypothalamic cells show a remarkable capacity to reorganize themselves within the proximal areas of the infundibular stalk and median eminence and form what has come to be known as a new 'mini neural lobe' . While the surviving neurons sprout new projections toward the level ...


Postnatal Observations Of Behavioral Patterns Within The Social Organization Of Captive Bottlenose Dolphins (Tursiops Truncatus), Stacey R. Hanson Nov 1997

Postnatal Observations Of Behavioral Patterns Within The Social Organization Of Captive Bottlenose Dolphins (Tursiops Truncatus), Stacey R. Hanson

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Mirage Dolphin Environment opened in 1991. The Mirage has eight Atlantic Bottlenose dolphins. Four of these dolphins were relocated to the facility from other facilities that were either overcrowded or shutting down. The other four were born at the Mirage. The purpose and intent of the Mirage Dolphin Environment is to provide a nurturing environment for the dolphins and to educate the public about marine mammals and their ecosystems. The increased awareness associated with education will hopefully encourage public support for efforts to conserve and protect marine mammals and their environment.


The Effect Of Lymph Sac Pressure On Lymph Heart Pressure Development In The Toad Bufo Marinus, Michael Georgitsis Oct 1997

The Effect Of Lymph Sac Pressure On Lymph Heart Pressure Development In The Toad Bufo Marinus, Michael Georgitsis

Dissertations and Theses

Lymph hearts play an important role in blood volume regulation in anurans by controlling the movement of fluid from the lymphatic spaces to the vasculature. The anatomical continuity between lymph sacs and lymph hearts predicts a coupling of pressure between the two structures which may represent a physical basis for lymph heart regulation. The precise relationship between lymph heart pressure and lymph heart output was not examined so that conclusions regarding changes in work performed by the hearts as a result of changing lymph sac pressure could not be made. However, increases in lymph sac pressure led to increases in ...


Sex Chromosome Ratios And Aneuploidy Rates In The Zona Pellucida Selected Spermatozoa From Normal And Subfertile Men, Qinuo Fan Van Dyk Oct 1997

Sex Chromosome Ratios And Aneuploidy Rates In The Zona Pellucida Selected Spermatozoa From Normal And Subfertile Men, Qinuo Fan Van Dyk

Theses and Dissertations in Biomedical Sciences

The human hemizona has been demonstrated to select spermatozoa with good motility, normal morphology, and the capacity to undergo the zona-induced acrosomal reaction. The studies conducted here are directed at using the human hemizona to investigate two key questions: (1) whether human X-chromosome bearing spermatozoa (X-sperm) and Y-chromosome bearing spermatozoa (Y-sperm) differ in their functional survival time (assessed by their capacity to bind to the human zona pellucida) after prolonged in vitro incubation, and (2) whether hemizona-bound spermatozoa have a reduced aneuploidy rate compared to unbound (and therefore, unselected) spermatozoa?

In the functional survival study, donor spermatozoa were held in ...


Human Trampling In The Upper Rocky Intertidal: Trampling And Recovery In Barnacle Mediated Succession, Timothy Lawrence Grubba Sep 1997

Human Trampling In The Upper Rocky Intertidal: Trampling And Recovery In Barnacle Mediated Succession, Timothy Lawrence Grubba

Dissertations and Theses

Marine intertidal ecosystems are vulnerable to human interference,

because trampling can be a significant problem. I studied the impacts of

trampling on community patterns and succession in a rocky intertidal

habitats. This study was divided into two phases: ( 1) a trampling phase and

(2) a recovery phase. Both phases are focused on two barnacles, Balanus

glandula and Chthamalus dalli, and on fucoid and red algae. The trampling

phase tested the effects of trampling on these organisms. The effects of

herbivores, primarily limpets (Collisella digitalis) were also tested to

determine whether anthropogenic (trampling) and natural (herbivory and

limpet bulldozing) disturbances had ...


Potential And Success In Spring 1994 Of Walleye Spawning In The Salmon River, Tyendinaga Territory, Ontario, Canada, Gordon John Mengel Aug 1997

Potential And Success In Spring 1994 Of Walleye Spawning In The Salmon River, Tyendinaga Territory, Ontario, Canada, Gordon John Mengel

Biology Master’s Theses

This study assessed the potential and success of walleye spawning in the lower Salmon River during Spring 1994. It was estimated that between 12,000 and 40,000 adult walleye migrated up the Salmon River from the Bay of Quinte to spawn between 12 April and 11 May 1994. Conditions for spawning and embryo development were nearly optimal with spawning substrate, water temperature, dissolved oxygen, and pH all optimal. However, volume and depth of the river decreased daily from the first day of spawning (14 April) to the end of spawning (May 10). Therefore, walleye eggs deposited in shallow areas ...


A Profile Of Antibiotic Resistant Bacteria In The James River, Keith Allen Boisvert Aug 1997

A Profile Of Antibiotic Resistant Bacteria In The James River, Keith Allen Boisvert

Master's Theses

Spatial and temporal variability in the antibiotic resistance of bacterial assemblages in the lower portion of the James River was examined. The antibiotic resistance of culturable coliforms was compared to the resistance in the microbial community. Antibiotic resistance was determined via colony formation on media containing antibiotics. The antibiotics ampicillin, chloramphenicol, streptomycin and tetracycline were used at concentrations ranging from 10 to 500 ug/ml. Statistically significant differences in the mean number of antibiotic resistant isolates were observed among both sample sites and dates. The sampling site at river mile 99 just below Richmond showed both increased antibiotic resistance and ...


The Vascular Flora Of The Upper Clinch River In Claiborne, Grainger, And Hancock Counties, Tennessee, Bobby Christopher Bullington Aug 1997

The Vascular Flora Of The Upper Clinch River In Claiborne, Grainger, And Hancock Counties, Tennessee, Bobby Christopher Bullington

Masters Theses

The vascular flora along a portion of the Upper Clinch River (UCR) in Claiborne, Grainger, and Hancock Counties, Tennessee was inventoried for two full growing seasons in 1994 and 1995. A total of 526 species and lesser taxa in 108 families and 338 genera were documented. Three hundred and twenty-six taxa were determined to be county records. Six taxa are state listed as threatened or special concern species in Tennessee.

Distributions of the taxa indicate a strong northern extraneous influence on the flora. However, intraneous elements still represent the single largest category. Northern taxa comprise almost 52% of the total ...


The Relationship Between Creativity And Leadership Traits Among Dietetic Professionals, Theresa Marie Cornelius Aug 1997

The Relationship Between Creativity And Leadership Traits Among Dietetic Professionals, Theresa Marie Cornelius

Masters Theses

The health care system is rapidly changing. In order to survive as a profession, dietetic professionals need to know about health care innovations and adapt to them. Leadership theories, such as transformational leadership may facilitate this adaptation. Transformational leaders are persuasive, creative, intuitive and have the ability to enhance these skills in others. This type of leadership facilitates organizational change and may be enhanced by creativity. Zemel and colleagues found that in Public Health Nutritionists the performance of both the innovator and broker roles were performed significantly less often than other leadership roles. These roles are paramount to dietetic professionals ...


A Biogeographic Review Of The Spider Genus Agelenopis (Araneae Agelenidae), Thomas Charles Paison Aug 1997

A Biogeographic Review Of The Spider Genus Agelenopis (Araneae Agelenidae), Thomas Charles Paison

Masters Theses

This study is a review of the biogeography of the North American spider genus Agelenopsis (Giebel) (Araneae: Agelenidae). Previous theoretical and empirical work provides support for the hypothesis that many North American taxa have been subject to disjunction and divergence due to the effects of Late Pleistocene glacial/interglacial cycles. A summary of the current knowledge of the biology and ecology of the 13 Agelenopsis species is developed and new distribution maps for each species are generated from published collections. A reconstructed phylogeny for the genus is created based on the adult sexual morphology of the species. A detailed hypothesis ...


The Role Of Free Radicals In The Plant's Response To Pathogen Attack In Tobacco, Phillip L. Peters Aug 1997

The Role Of Free Radicals In The Plant's Response To Pathogen Attack In Tobacco, Phillip L. Peters

Master's Theses

Previous studies have implicated the involvement of free radicals, specifically reactive oxygen species (ROS), as a key component in plant response to pathogen attack. In this study we examined the effect free radical scavenging compounds have on lesion area, salicylic acid levels, catalase, and superoxide dismutase in response to inoculation with Tobacco Mosaic Virus (TMV), a viral pathogen. Hydroponically grown Nicotiana tabacum (Xanthi nc) were pretreated with one of two antioxidants, either purpurogallin (PPG) or N-acetyl cysteine (NAC). Antioxidants were supplied to the plant via the root system and the leaves were subsequently challenged by inoculation with theTMV. Leaf material ...


A Pouplation Genetic Study Of Wild Bottlenose Dolphins (Tursiops Truncatus) In Matagorda Bay, Texas, Joel Stephen Lenox Jul 1997

A Pouplation Genetic Study Of Wild Bottlenose Dolphins (Tursiops Truncatus) In Matagorda Bay, Texas, Joel Stephen Lenox

Dissertations and Theses

A long-term photoidentification study was initiated in response to an unusually high incidence of bottlenose dolphin mortality between Corpus Christi and Matagorda Bays, Texas. Blood samples from 36 captured and released animals were analyzed using three genetic techniques; mtDNA haplotyping, nuclear DNA fingerprinting and electrophoretic analysis of hemoglobin. Two Hinf I mtDNA haplotypes previously described in bottlenose dolphins from other locations within the Gulf of Mexico were discovered. Similarity Indices (SI) were calculated based on nuclear DNA fingerprinting data. These SI values were used as a relative measure of relatedness between two individuals run on the same gel. Means of ...


Ovarian Steroid Regulation Of Tryptophan Hydroxylase Enzyme Level In The Midbrain Raphe In Ovariectomized Guinea Pigs, Zhidong Lu Jul 1997

Ovarian Steroid Regulation Of Tryptophan Hydroxylase Enzyme Level In The Midbrain Raphe In Ovariectomized Guinea Pigs, Zhidong Lu

Dissertations and Theses

Progesterone stimulates prolactin secretion in estrogen ( estradiol-17-~)primed monkeys and guinea pigs. It is hypothesized that the serotonin neural system plays a pivotol role in mediating the effect of progesterone on prolactin secretion. Indeed, progesterone, but not estrogen, increases serotonin levels in the midbrain raphe in guinea pigs. However, estrogen alone stimulates gene expression of the rate-limiting enzyme for serotonin synthesis, tryptophan hydroxylase (TPH), and progesterone supplement to the estrogen regimen has no additive effect, as indicated by TPH mRNA levels in monkeys. The discrepancy between ovarian steroid effects on the TPH mRNA level and the serotonin level might be ...


Characterization Of A Tn4351-Generated Hemin Uptake Mutant Of Porphyromonas Gingivalis: Evidence For The Coordinate Regulation Of Virulence Factors By Hemin, Waltena Simpson Jul 1997

Characterization Of A Tn4351-Generated Hemin Uptake Mutant Of Porphyromonas Gingivalis: Evidence For The Coordinate Regulation Of Virulence Factors By Hemin, Waltena Simpson

ETD Collection for AUC Robert W. Woodruff Library

The ability of Porphyromonas gingivalis to acquire iron in the iron-limited environment of the host is crucial to the colonization of this organism. Here, the isolation and characterization of a transpositional insertion mutant of P. gingivalis A7436 (designated MSM-3) which is defective in the utilization and transport of hemin, is reported. P. gingivalis MSM-3 was initially selected on the basis of its non-pigmented colony phenotype on anaerobic blood agar plates following mutagenesis with the Bacteroides fragilis transposon Tn4351. P. gingivalis MSM-3 grew poorly when supplies with hemin as a sole source of iron; however growth was observed with hemoglobin or ...


Cytoskeletal Dynamics And Cellular Differentiation Influence Tumor Progression And Metastatic Potential In Prostate Adenocarcinoma, Carlton Dewitt Donald Jul 1997

Cytoskeletal Dynamics And Cellular Differentiation Influence Tumor Progression And Metastatic Potential In Prostate Adenocarcinoma, Carlton Dewitt Donald

ETD Collection for AUC Robert W. Woodruff Library

Cancer cell attachment to and invasion of an extracellular matrix has been associated with metastatic potential. Recently it has become apparent that the extracellular matrix may influence several phenotype properties of metastatic cancer cells. The mechanisms which regulate prostate cancer growth and metastasis may be particularly relevant to the development of clinical strategies for better understanding and ultimate treatment and control of the disease.

Cell-matrix interactions of prostate tumor cells were investigated by comparing the invasive ability through and attachment to reconstructed extracellular matrix components. A correlation was found between metastatic potential and adhesive ability. Non-metastatic AT-1 cells possessed a ...


In Vivo Regulation Of Murine Cytomegalovirus Infections: The Role Of Cell Surface Molecules And Mechanisms Of Control By Natural Killer Cells: A Dissertation, Chin Hun Tay Jul 1997

In Vivo Regulation Of Murine Cytomegalovirus Infections: The Role Of Cell Surface Molecules And Mechanisms Of Control By Natural Killer Cells: A Dissertation, Chin Hun Tay

GSBS Dissertations and Theses

The overall aim of this thesis was to determine how natural killer (NK) cells regulate virus infections in vivo. Anti-viral mechanisms by which NK cells control murine cytomegalovirus (MCMV) infection in the spleens and livers of adult C57BL/6 mice were first studied, revealing different mechanisms of control in different organs. Three days post-infection, MCMV titers in the spleens of perforin-deficient (perforin 0/0) mice were higher than in wild type controls, but no elevation of liver titers was found in perforin 0/0 mice. NK cell depletion in MCMV-infected perforin 0/0 mice resulted only in an increase in ...