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Theses/Dissertations

1995

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Articles 1 - 30 of 316

Full-Text Articles in Life Sciences

An Assessment Of Nutrition Policies And Practices In Licensed Child Care Agencies In Tennessee, Nicole Anne Cunningham Dec 1995

An Assessment Of Nutrition Policies And Practices In Licensed Child Care Agencies In Tennessee, Nicole Anne Cunningham

Masters Theses

Objective Research was conducted to determine the extent to which a sample of licensed child care agencies in Tennessee met 31 nutrition and food service standards as contained in the National Health and Safety Performance Standards: Guidelines for Out-of-Home Child Care Programs and to identify any significant differences by type of agency, USDA Child and Adult Care Food Program (CACFP) participation, and profit status.

Design A random sample of 300 licensed child care agencies stratified by type was surveyed by mailed questionnaire composed of 59 open and closed-ended items and five-point Likert-like scaled items. Three primary scores were calculated to ...


Crop Tree Management Of Upland Hardwoods In West Tennessee, David O'Neal Dec 1995

Crop Tree Management Of Upland Hardwoods In West Tennessee, David O'Neal

Masters Theses

A 40-year-old upland hardwood stand in west Tennessee was selected to test the effectiveness of crop tree management techniques. The stand consisted of 20 acres with each acre having the potential to contain 36 crop trees. Treatments consisted of: 1) a crown release, 2) fertilization (150 lbs. N and 35 lbs. P205 per acre) and 3) a combined release and fertilizer treatment.

A severe ice storm struck west Tennessee the winter following the study's initiation. Results indicated that release greatly increased a crop tree's susceptibility to severe ice damage and that black cherry (Prunus serotina ...


Gis Modeling Of Forest Cover Distributions In A Southern Appalachian Watershed, Daniel Thomas Rutledge Dec 1995

Gis Modeling Of Forest Cover Distributions In A Southern Appalachian Watershed, Daniel Thomas Rutledge

Masters Theses

This study develops a method to model forest cover distributions in the Little Tennessee River Watershed in Macon County, North Carolina using a geographic information system (GIS). The model employs common environmental variables, e.g. elevation, aspect, and slope, and a newly developed metric called a topographic index. The topographic index quantifies landscape form to reflect the degree of site convexity or concavity. To generate index values, the GIS sums relative aspect differences between all adjacent cells and the center cell in a neighborhood analysis. To determine predominant community types and their environmental ranges in the study area, I surveyed ...


Incidence And Life History Of Beech Scale, Initiator Of Beech Bark Disease, In The Great Smoky Mountains National Park, Robert Angelo Vance Dec 1995

Incidence And Life History Of Beech Scale, Initiator Of Beech Bark Disease, In The Great Smoky Mountains National Park, Robert Angelo Vance

Masters Theses

American beech, Fagus grandifolia Ehrlich, in eastern North America are currently threatened by the devastating beech bark disease. This disease is caused by the fungal pathogens, Nectria coccinea var. faginata Lohman, Watson and Ayers, and Nectria galligena Bres., which infect trees that are predisposed by infestations of beech scale, Cryptococcus fagisuga Lindinger. In 1993, beech bark disease was discovered in the Great Smoky Mountains National Park (GSMNP).

In 1994, a 2-year cooperative research project involving the National Park Service and the University of Tennessee Agricultural Experiment Station was initiated to study several aspects of beech bark disease in the GSMNP ...


Foodservice Conditions In Licensed Urban And Rural Child Care Centers: An Application Of The National Health And Safety Performance Standards, Todd Michael Kirkpatrick Dec 1995

Foodservice Conditions In Licensed Urban And Rural Child Care Centers: An Application Of The National Health And Safety Performance Standards, Todd Michael Kirkpatrick

Masters Theses

Objectives: To assess the degree to which child care centers in urban and rural counties met foodservice standards as documented in the National Health and Safety Performance Standards; to determine if a difference in foodservice conditions existed between these two groups; to determine if the foodservice conditions at child care centers are related to the directors' perception of existing foodservice conditions or the importance of maintaining safe foodservice conditions, or previous environmental health inspection scores; to identify child care staffing needs.

Subjects: 36 urban and 34 rural child care centers in east Tennessee

Design: On-site assessment of food production facilities ...


Identification Of An Insulin-Responsive Element In The Rat Glucose-6-Phosphate Dehydrogenase Gene, Sheri Lynn Holmen Dec 1995

Identification Of An Insulin-Responsive Element In The Rat Glucose-6-Phosphate Dehydrogenase Gene, Sheri Lynn Holmen

Master's Theses

The expression of several genes has been shown to be either positively or negatively regulated by insulin at the transcriptional level, however no single insulin responsive DNA element has yet been identified. The transcription factors responsible for stimulation or inhibition of gene expression by insulin also remain to be identified. In recent years, expression of the gene for glucose-6-phosphate dehydrogenase (G6PDH) in primary rat hepatocytes has been found to be influenced by hormones such as insulin, dexamethosone, and glucagon. The molecular mechanism(s) however, underlying hormonal regulation of G6PDH gene transcription remains to be elucidated. The focus of this study ...


Reverse Osmosis Treatment Of Deinking Effluents, Lei Zhao Dec 1995

Reverse Osmosis Treatment Of Deinking Effluents, Lei Zhao

Master's Theses

The application of the reverse osmosis process for treatment of preclarified deinking effluent was studied for its efficiency and capacity to remove the total suspended and dissolved solids. Seven coagulants and flocculents were studied in the pretreatment to determine the best coagulant. Two variables, temperature and coagulant dose, were studied to determine the optimum conditions. For the reverse osmosis treatment, two types of thin film composite membranes, sea water and brackish water were used in the research. A set of orthogonal experiments and regression analyses were conducted to study the effects of pressure, temperature, feed concentration, and feed pH on ...


Regulation Of Leukotriene C4 Biosynthesis In Calcium Ionphore A23187-Challeneged August Rat Peritoneal Leukocytes, James M. Huebner Dec 1995

Regulation Of Leukotriene C4 Biosynthesis In Calcium Ionphore A23187-Challeneged August Rat Peritoneal Leukocytes, James M. Huebner

Master's Theses

Leukotriene (LT) C4 is a potent myotropic product of arachidonic acid 5-lipoxygenation that is thought to play a role in the pathophysiology of immediate hypersensitivity reactions and inflammation. We designed the present study to evaluate the capacity of August (AUG) rat mixed peritoneal leukocytes to generate LTC4 when challenged with different concentrations of the Ca2+ ionophore A23187 and to test the hypothesis that LTC4 biosynthesis is regulated via a protein kinase C (PKC)-dependent mechanism. The AUG rat, which has a spontaneously high number of peritoneal eosinophils that can be harvested by a simple lavage procedure ...


Dna Sequences Involved In The Regulation Of Human C-Myc Gene Expression By Herpes Simplex Virus Type 1 (Hsv-1), Shanli Ye Nov 1995

Dna Sequences Involved In The Regulation Of Human C-Myc Gene Expression By Herpes Simplex Virus Type 1 (Hsv-1), Shanli Ye

Dissertations and Theses

The human c-myc gene is a cellular proto-oncogene composed of three exons and two introns. Transcription of c-myc is controlled by two promoters, Pl and P2. The activity of these promoters is regulated by many factors, such as cellular transcription factors E2F, YYl, and HSV-1 immediate-early proteins, ICPO, ICP4. Many regulatory elements located both upstream of and between P 1 and P2 have been identified, and some of these are required for optimum expression of c-myc. In this thesis research, a region downstream from P2 in the c-myc exon 1 was identified by its response to transactivation by HSV-1 immediate-early ...


Chromatin Structure Of The Rat Osteocalcin Gene Promoter In Bone-Derived Cells, Martin A. Montecino Nov 1995

Chromatin Structure Of The Rat Osteocalcin Gene Promoter In Bone-Derived Cells, Martin A. Montecino

GSBS Dissertations and Theses

Transcription of the osteocalcin gene, which encodes a bone-specific 10 kDa protein, is controlled by the coordinated utilization of modularly organized basal and hormone-responsive enhancer elements. Activation of these sequences involves the interaction of specific transcription factors to these promoter elements. It is becoming increasingly accepted that nuclear architecture provides a basis for support of tightly regulated modulation of cell growth and tissue-specific transcription which is required for the onset and progression of differentiation. Thus packaging of DNA as chromatin can facilitate the cooperative interaction between activities of independent regulatory elements that contribute to the level of transcription. Here, we ...


Molecular Characterization Of Mitofilin, A Novel, Mitochondrial, Coiled Coil Protein, And The Relationship Between Organism Complexity And Coiled Coil Protein-Mediated Structure: A Dissertation, Paul R. Odgren Nov 1995

Molecular Characterization Of Mitofilin, A Novel, Mitochondrial, Coiled Coil Protein, And The Relationship Between Organism Complexity And Coiled Coil Protein-Mediated Structure: A Dissertation, Paul R. Odgren

GSBS Dissertations and Theses

In the course of experiments designed to identify and characterize structural proteins of the nuclear matrix, one antibody was generated which recognized an extraction-resistant cytoplasmic protein. This antibody was used as the starting point in the cloning and molecular characterization of a novel protein of the inter-membrane space of the mitochondrion which has been named mitofilin. Mitofilin is expressed in all human cell types, and murine homologues also exist. Mitofilin associates only with mitochondria and not with other membrane-bounded organelles such as Golgi or endoplasmic reticulum. This observation has been confirmed both by biochemical fractionation and multi-label fluorescence microscopy. Recombinant ...


Evaluation Of Alternative Crop Rotational Schemes For Cotton Production In Louisiana, Asitava Jana Oct 1995

Evaluation Of Alternative Crop Rotational Schemes For Cotton Production In Louisiana, Asitava Jana

LSU Historical Dissertations and Theses

Increasing economic importance of cotton production in Louisiana, awareness of the financial and environmental benefits of crop rotations have stressed the need for evaluating cotton production in different rotational schemes. The objective of this study was to estimate profitability of alternative crop rotational schemes within a whole farm context. Yield data for 11 alternative production systems involving cotton, soybean, corn, wheat were obtained from the ongoing crop rotation research at the Northeast Research Station during the period 1983 -1993. Th e systems included continuous, 2 year, and 3 year rotations on two soil types: silt and clay. Price data were ...


Biochemical And Molecular Characterization Of The Prostate-Specific Membrane Antigen (Psma), John Karl Troyer Oct 1995

Biochemical And Molecular Characterization Of The Prostate-Specific Membrane Antigen (Psma), John Karl Troyer

Theses and Dissertations in Biomedical Sciences

Prostate cancer is the most common malignancy and the second leading cause of cancer death in males in the United States. Additionally, the number of deaths attributed to prostate cancer is increasing at a rate of approximately 8% a year. Development of new diagnostic and therapy strategies are needed in order to improve the life expectancy of patients with this disease. One tool which may allow for improvements in prostate cancer diagnosis and therapy is the monoclonal antibody (MAb) 7E11-C5.3 which was first described in 1987. Since then, the antigen recognized by MAb 7E11-C5.3 has been named the ...


Cloning And Cell Cycle Analysis Of Numa, A Phosphoprotein That Oscillates Between The Nucleus And The Mitotic Spindle, Cynthia A. Sparks Sep 1995

Cloning And Cell Cycle Analysis Of Numa, A Phosphoprotein That Oscillates Between The Nucleus And The Mitotic Spindle, Cynthia A. Sparks

GSBS Dissertations and Theses

The overall objective of this study was to identify novel proteins of the nuclear matrix in order to contribute to a better understanding of nuclear structure and organization. To accomplish this, a monoclonal antibody specific for the nuclear matrix was used to screen a human λgt11 expression library. Several cDNAs were isolated, cloned, sequenced, and shown to represent NuMA, the nuclear mitotic spindle apparatus protein. Further characterization of the gene and RNA was undertaken in an effort to obtain information about NuMA. The NuMA gene was present at a single site on human chromosome 11q13. Northern and PCR analysis of ...


Shoot Structure Of Boschniakia Hookeri Walpers (Orobanchaceae), John Leland Babur Aug 1995

Shoot Structure Of Boschniakia Hookeri Walpers (Orobanchaceae), John Leland Babur

Dissertations and Theses

Boschniakia hookeri Walpers has been found to parasitize the roots of Gaultheria shallon Pursh, Arctostaphylos uva-ursi (l.) Spreng, and Vaccinium ovatum Pursh, all members of the Ericaceae. This is the first documented report of the parasitism of Vaccinium ovatum. The subterranean shoot of B. hookeri originates endogenously from the perennial tubercle of the parasite. The shoot has an eustele, composed of collateral vascular bundles, arranged in four composite fronts and separated by four wide 'leaf gaps.' Pits on metaHylem vessels range from nearly circular to laterally elongated. Rll vessel members have simple perforations. Ouerall, the Hylem of subterranean shoots contained ...


Movement Ecology Of Black Bears In A Fragmented Bottomland Hardwood Habitat In Louisiana, Forrest B. Marchinton Aug 1995

Movement Ecology Of Black Bears In A Fragmented Bottomland Hardwood Habitat In Louisiana, Forrest B. Marchinton

Masters Theses

Twelve Louisiana black bears (Ursus americanus luteolus) were captured 18 times on a 350-km2 study area in the Tensas River Basin in northeastern Louisiana during 1992 and 1993. The study area, owned by Deltic Farm and Timber Co., Inc., consisted of 4 bottomland hardwood habitat fragments, several smaller woodlots, and extensive agricultural fields.

A total of 3,748 locations were collected on 10 radio-collared bears (4 male, 6 female). Mean home ranges were 52.33 km2 and 12.61 km2 for males and females, respectively, and were largest during the fall. Home range overlap, particularly among females ...


An Evaluation Of Nutrition Services Delivered To Wic High-Risk Prenatal Women By Three Nutrition Provider Types In A Regional Rural Health Department, Bonnie Lynn House Aug 1995

An Evaluation Of Nutrition Services Delivered To Wic High-Risk Prenatal Women By Three Nutrition Provider Types In A Regional Rural Health Department, Bonnie Lynn House

Masters Theses

Objective: To determine if differences existed in pregnancy outcomes and quality of nutrition care delivered to WIC high-risk prenatal women by three nutrition provider types.

Design: A seven month retrospective medical record audit

Subjects/Setting: WIC high-risk prenatal women who met the following criteria, underweight for height, enrolled in WIC ≤ 32 weeks gestation, no other primary certification codes, and could have iron deficiency anemia, were sampled from a 23 county regional rural health department (n=146). The women were divided into three groups based on the provider type classification during their prenatal WIC enrollment.

Main outcome measures: An audit tool ...


A Repeatable, Visual Survey Of Three Rare Percina (Osteichthyes: Percidae) Fish In Little River, Blount County, Tennessee, Charles H. Heacock Aug 1995

A Repeatable, Visual Survey Of Three Rare Percina (Osteichthyes: Percidae) Fish In Little River, Blount County, Tennessee, Charles H. Heacock

Masters Theses

A recent apparent decline of the darter species in Little River, Blount County, Tennessee, suggested a deterioration on habitat quality was taking place. The objective of this study was to establish a baseline of the abundance and distribution of three large and easily recognized darter species (Percina aurantiaca, P. burtoni, and P. macrocephala) believed to be very pollution intolerant.

The study area included 27 river miles with 20 accessible sites which were determined by an area reconnaissance. Each site has been described, including diagrams and photographs, and was surveyed six times between July and October 1993. A review of published ...


Effects Of Polymers On Pressure Water Retention And Binder Migration Of Aqueous Coatings, Arvind M. Singhal Aug 1995

Effects Of Polymers On Pressure Water Retention And Binder Migration Of Aqueous Coatings, Arvind M. Singhal

Master's Theses

The effects of the molecular properties (degree of polymerization and degree of substitution) of water soluble polymers (containing carboxyl and hydroxyl groups on cellulosic backbone) on water retention under pressure and subsequent binder migration of coating colors are documented. It is concluded that no single mechanism can explain either water retention or binder migration. The dominant mechanisms of water penetration under dynamic pressure pulse are different from the mechanisms of water absorption under static pressure.

It is proposed that the molecular properties affect the rate of consolidation of the coating layer and thus greatly affect the water penetration under a ...


The Role Of Pulmocutaneous Baroreceptors In The Control Of Lymphatic Heart Rate In The Toad Bufo Marinus, Dane Alan Crossley Ii Jul 1995

The Role Of Pulmocutaneous Baroreceptors In The Control Of Lymphatic Heart Rate In The Toad Bufo Marinus, Dane Alan Crossley Ii

Dissertations and Theses

The present study documents that baroreceptors located in the pulmocutaneous artery (PCA) are key components in control of lymph heart rate in amphibians. A negative feedback control loop exists between arterial pressure and lymphatic heart rate. The recurrent laryngeal nerve (rLN), which innervates the PCA baroreceptors, transmits information on arterial pressure to integration centers in the central nervous system. Lymphatic heart rate (LHR) is reduced as a result of increases in arterial pressure. This loop was determined using three experimental protocols. First, the correlation between LHR reduction and hormonally induced vasoconstriction was determined. Increases in arterial pressure due to pressor ...


Renal Responses To Differential Rates Of Blood Volume Expansion In The Toad, Bufo Marinus, Mark Edward Bolke Jul 1995

Renal Responses To Differential Rates Of Blood Volume Expansion In The Toad, Bufo Marinus, Mark Edward Bolke

Dissertations and Theses

Three aspects of renal function were measured in the toad, Bufo marinus (N=lO): (1) effect of rate of blood volume expansion on renal functions (UFR; GFR; urine and plasma ion concentrations; and ion excretion rates), (2) effect of hypo- and hyperosmotic blood volume expansions on renal functions, and (3) role of GFR and tubular processes in the differential response of UFR under different osmotic expansion stresses. Renal responses to differential rates of blood volume expansion have not been investigated in amphibians. Rate responses will be analyzed considering effects: ( 1) during infusion (neural, or, short term regulation of extracellular fluid ...


Variation In Plasma Prostaglandin E2 Level In Mouse During Infection With Trichinella Spiralis And Trichinella Pseudospiralis, Zahra Mehdizadehkashi Jul 1995

Variation In Plasma Prostaglandin E2 Level In Mouse During Infection With Trichinella Spiralis And Trichinella Pseudospiralis, Zahra Mehdizadehkashi

Dissertations and Theses

Polymorphonuclear leukocytes infiltrate tissues in response to an inflammatory stimulus such as endotoxin or parasite products. Previous studies have shown an extensive cellular infilteration about the parasitized skeletal muscle of mouse infected with the nematode, Trichinella spiralis. Infection of the host with Trichinella pseudospiralis, on the other hand, is associated with a dramatic suppression of inflammatory cellular response. Prostaglandin Bi is a product of arachidonic acid metabolism and is synthesized by variety of cell types. Prostaglandins of the E series have been generally known to suppress inflammatory responses. In the present study, I have investigated the possible relation between plasma ...


The Chemotactic Response Of Neutrophils To Components Of The Sera Of Mice Infected With Trichinella Spiralis, Sara Lynn Youngman Jul 1995

The Chemotactic Response Of Neutrophils To Components Of The Sera Of Mice Infected With Trichinella Spiralis, Sara Lynn Youngman

Dissertations and Theses

Neutrophils accumulate around Trichinella spiralis larvae encysted in skeletal muscle cells of the host. The magnitude of the neutrophil infiltration follows a pattern relating to the stage of infection of T.spiralis. This study was performed to determine if there are factors chemotactic for neutrophils present in the sera of mice infected with T.spiralis, and if present, to compare the chemotactic potential of sera from several time points during the infection. Female MRL++ mice hosted the T.spiralis infection and provided neutrophils for all experiments. The chemotactic potentials of sera were tested by placing 150 ul of serum collected ...


In Vitro Expression Of Human Zona Pellucida Protein 3, Chih-Wei Chen Jul 1995

In Vitro Expression Of Human Zona Pellucida Protein 3, Chih-Wei Chen

Theses and Dissertations in Biomedical Sciences

Human zona pellucida protein 3 (hZP3) is the putative receptor on the zona pellucida of the mature oocyte that recognizes and binds sperm, and therefore plays a critical role in fertilization.

A full length cDNA of hZP3 (1278 bp) was amplified from the human ovary mRNA by reverse transcription-polymerase chain reaction (RT-PCR). The hZP3 cDNA was subcloned into PSK and pREP4 expression vectors. The cDNA of hZP3 was further characterized by restriction mapping, PCR, auto-sequencing and Southern blot analysis by using an internal oligonucleotide probe, and found to be identical to the one reported by J. Dean. Using autosequencing, 289 ...


Demography, Reproduction, Diet And Crop Depredation In Three Species Of Rodents In Natural And Irrigated Fields In Nigeria, Safianu Rabiu Jul 1995

Demography, Reproduction, Diet And Crop Depredation In Three Species Of Rodents In Natural And Irrigated Fields In Nigeria, Safianu Rabiu

Biological Sciences Theses & Dissertations

Rodent populations of Arvicanthis, Mastomys and Tatera were studied during July 1990 to August 1992 in both natural and irrigated savannah fields of northern Nigeria. Tatera was entirely absent from the irrigated fields. Irrigation enhanced higher rodent population densities in the magnitude of three to four times over densities in the natural field. Arvicanthis was the most abundant of the three species in both sites. Tatera was the least common in the natural site. Adult survival rates in Arvicanthis and Tatera were significantly higher than Mastomys. Survival rates of both adult and young differed between the wet and dry seasons ...


Identification And Characterization Of Mitochondrial Dna Variants In Alzheimer's Disease, Natasha Singh Hamblet Jul 1995

Identification And Characterization Of Mitochondrial Dna Variants In Alzheimer's Disease, Natasha Singh Hamblet

Theses and Dissertations in Biomedical Sciences

Alzheimer's Disease (AD) is a complex neurodegenerative disorder that affects a significant portion of the human population regardless of ethnicity or gender. A mitochondrial hypothesis of AD has been proposed based on a number of studies which establish altered oxidative phosphorylation (OXPHOS) and ATP synthesis in AD tissue. ATP demand is most prevalent in the brain; damage to OXPHOS could severely impair brain metabolism, thereby leading to a decline in cognitive function. Four out of five complexes in the OXPHOS pathway are partly encoded by mitochondrial DNA (mtDNA); thus, this may be a crucial site of lesions that alter ...


Investigation Of The Substrate Recognition Characteristics And Kinetics Of Mammalian Mitochondrial Dna Topoisomerase I, Zeki Topcu Jul 1995

Investigation Of The Substrate Recognition Characteristics And Kinetics Of Mammalian Mitochondrial Dna Topoisomerase I, Zeki Topcu

Theses and Dissertations in Biomedical Sciences

Topoisomerases are DNA-modifying enzymes found in prokaryotes, eukaryotes, viruses and organelles such as chloroplast and mitochondria. Information about these enzymes in eukaryotic systems is mostly limited to nuclear enzymes, although our laboratory has been characterizing the biochemical and biophysical properties of the mammalian mitochondrial topoisomerases. We have determined the polarity of the attachment of mitochondrial topoisomerase I to its substrate DNA. To study the substrate preference and kinetic parameters of mitochondrial topoisomerase I, selected regions of mammalian mitochondrial DNA (mtDNA) were inserted into pGEM plasmid vectors following a series of modification and optimization experiments of currently available methods for PCR-cloning ...


The Interaction Of Coated Paper Surfaces And Water- And Solvent-Based Rotogravure Printing Inks, Tanja M. Gnad Jun 1995

The Interaction Of Coated Paper Surfaces And Water- And Solvent-Based Rotogravure Printing Inks, Tanja M. Gnad

Master's Theses

The print quality of 24 different coating formulations was studied when printing with both water- and solvent-based rotogravure ink. Coating was done on a Cylindrical Laboratory Coater (CLC). The coated paper samples were supercalendered to achieve a smooth surface which is necessary when printing with rotogravure. The supercalendered coated paper samples where tested for optical and surface properties and also printed with water-based and solvent-based ink on a Moser Gravure Proof Press. The print quality of the printed samples was quantified by image analysis. The results showed that fine ground calcium carbonate gave the lowest percent bridging between ink dots ...


The Effects Of Repulping Variables On Deinking Of Flexographic Inks, Sylvia Ciampa Jun 1995

The Effects Of Repulping Variables On Deinking Of Flexographic Inks, Sylvia Ciampa

Master's Theses

The effects of repulping variables (pH, surfactant concentration, time, and temperature) on deinking paper printed with flexographic ink were studied. A series of alcohol ethoxylate surfactants was evaluated. The one with HLB= 11.8 was selected for the majority of the study.

pH was the variable that presented the greatest effect on repulping and deinking. The brightness after repulping and the final brightness after deinking was significantly higher at pH 5 than at pH 9.

Paper was repulped for 15, 25, and 40 minutes respectively. Highest brightness after repulping and highest gain in brightness by flotation was observed after 15 ...


Differential Distribution Of D4 And D2 Dopamine Receptors In Rat Brain: An Autoradiographic Study Using [3H]Ym-09151-2 And [3H]Raclopride, Nancy C. Stratman Jun 1995

Differential Distribution Of D4 And D2 Dopamine Receptors In Rat Brain: An Autoradiographic Study Using [3H]Ym-09151-2 And [3H]Raclopride, Nancy C. Stratman

Master's Theses

Extrapyramidal side effects (EPS) are associated with most antipsychotics for the treatment of schizophrenia since these agents antagonize dopamine D2 receptors in the nigrostriatal pathway, a brain system that regulates motor functions. Clozapine, an atypical antipsychotic agent in that it does not produce EPS, was found to be more selective for the D4 than the D2 receptor. The purpose of this study was to locate the D4 receptor in rat brain by autoradiographic comparison studies with [3H]YM-09151-2, a D2 , D3, and D4 radioligand, to [3H]raclopride, a D2 and ...