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Theses/Dissertations

Theses and Dissertations

Androgen receptor

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Full-Text Articles in Life Sciences

Quantitative Proteomics Of Androgen Receptor-Mediated Signaling Networks In Prostate Tumor Cells, Jordy Jame Hsiao May 2015

Quantitative Proteomics Of Androgen Receptor-Mediated Signaling Networks In Prostate Tumor Cells, Jordy Jame Hsiao

Theses and Dissertations

Aberrant androgen receptor (AR) activity plays a critical role in the development and progression of both early-staged organ-confined and late-staged metastatic human prostate cancer. Recent large-scale genomic sequencing studies showed that ~50% of organ-confined prostate cancer patients have genetic rearrangements that placed the ETS transcription factors (e.g. ERG, ETV1) under the control of androgen-regulated gene promoters such as TMPRSS2. This results in the upregulation of the ETS transcription factors’ expressions in the presence of androgens. The aberrant overexpression of the ETS transcription factors are shown to induce the expression of genes that promote the cellular motility and invasive potential ...


Exposure To Dietary Selenium And Soy Isoflavones In Utero Provides Greater Protection Against Prostate Cancer Risk Factors In Tramp Mice Than Exposure Beginning At 6 Weeks, Heather Schofield Lindsay Jun 2012

Exposure To Dietary Selenium And Soy Isoflavones In Utero Provides Greater Protection Against Prostate Cancer Risk Factors In Tramp Mice Than Exposure Beginning At 6 Weeks, Heather Schofield Lindsay

Theses and Dissertations

Prostate cancer is the second most commonly occurring cancer in men in the United States. Generally, an extended period of time is needed for a mutation to develop into a full scale tumor. Because of this long latency period, lifestyle and environmental factors, such as diet, may play an important role in the development and progression of the disease. Diet is one factor that has been implicated in the risk for developing prostate cancer. We previously showed that diets high in soy isoflavones and selenium (Se) decreased androgen receptor expression and expression of androgen regulated genes in healthy rat prostates ...


Chemopreventive Effects Of Dietary Selenium And Soy Isoflavones In A Mouse Model Of Prostate Cancer, Trevor Elisha Quiner Jun 2010

Chemopreventive Effects Of Dietary Selenium And Soy Isoflavones In A Mouse Model Of Prostate Cancer, Trevor Elisha Quiner

Theses and Dissertations

Prostate cancer is the most commonly diagnosed non-skin cancer in men and the second leading cause of cancer death in the United States. Prostate cancer, like many cancers, is a disease that generally requires a long period of time to develop and grow before it becomes detectable. This long period of latency makes prostate cancer a candidate for dietary chemoprevention. Soy and selenium (Se), are associated with a decreased risk of prostate cancer. We previously showed that high dietary intake of selenium (Se) and soy isoflavones decreased the expression of the androgen receptor (AR) and AR-regulated genes in the prostates ...