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Theses/Dissertations

Master's Theses and Project Reports

2012

Cellular Differentiation

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A Proteomic Analysis Of Differentiation In The Mammary Epithelium, Laura Therese Strand Jun 2012

A Proteomic Analysis Of Differentiation In The Mammary Epithelium, Laura Therese Strand

Master's Theses and Project Reports

While a great deal is known about the changing hormonal environment and the structural development of the mammary gland from pregnancy to lactation, very little is known about the molecular mechanisms governing differentiation of the mammary epithelium into a milk-secreting phenotype. It is important to acknowledge the diversity among the mammary glands of different species in order to better understand applications in human health and the dairy industry. In this study, we examined global protein expression during two states of differentiation in mammary epithelial cells from two species: in vitro proliferating and differentiated MAC-T cells (a bovine immortal cell-line), and ...