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Characterization Of Ca2+ Influx Pathway(S) During Mouse Oocyte Maturation, Banyoon Cheon
Ca2+ signaling induced at fertilization, also known as oscillations, is essential in mammalian eggs to initiate early embryonic development. The generation of the oscillations relies on optimization of Ca2+ toolkit components during oocyte maturation. In this dissertation, we intend to deepen our understanding of how this differentiation of the Ca2+ toolkit, especially those components associated with Ca2+ influx, is achieved during maturation, and how it contributes to the filling of the ER Ca2+ store during the maturation and fertilization.
We first identified the expression and characterized the function of the components of the Store Operated ...