Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Structural Biology And Pharmacology Of Human Cathepsin A And Neuraminidase 1, Nilima Kolli
Human cathepsin A (also known as Protective Protein/Cathepsin A, PPCA; E.C. 126.96.36.199) is a lysosomal serine carboxypeptidase. Cathepsin A is also involved in a complex with two other lysosomal enzymes: lysosomal neuraminidase (NEU1, E.C. 188.8.131.52) and β-galactosidase (GLB1, E.C. 184.108.40.206). Deficiency in cathepsin A and NEU1 result in the lysosomal storage diseases, galactosialidosis and sialidosis respectively. Deficiency in GLB1 results in GM1 gangliosidosis and Morquio B diseases.
Cathepsin A protease activity is spatially regulated by activation of the inactive precursor form to the mature form in ...