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Mitochondrial Aspects Of Neuronal Pathology In Triple-Transgenic Alzheimer’S Disease Mice, John Zachary Cavendish Jan 2021

Mitochondrial Aspects Of Neuronal Pathology In Triple-Transgenic Alzheimer’S Disease Mice, John Zachary Cavendish

Graduate Theses, Dissertations, and Problem Reports

Alzheimer’s disease (AD) is a fatal, progressive neurodegenerative disease afflicting millions of people in the United States alone and is the only one of the top leading causes of morbidity and mortality with no effective disease-modifying therapies. It is the most common form of dementia, affecting one in three people over the age of 85. While the hallmarks of the disease include accumulation of beta-amyloid-based extracellular plaques and hyperphosphorylated tau-based intracellular neurofibrillary tangles, treatment strategies centered on removing or mitigating these components of AD have all failed in humans. Mitochondrial dysfunction has been increasingly recognized as an early and ...


The Effects Of Increasing Running Speed On Vgrf And Asymmetry, Kaela M. Hierholzer Aug 2020

The Effects Of Increasing Running Speed On Vgrf And Asymmetry, Kaela M. Hierholzer

Electronic Theses and Dissertations

Biomechanical and physiological parameters related to running performance are usually studied separately. However, evaluating both aspects together could be beneficial in improving athletic performance. The purpose of this study was to observe the change in peak vGRF and asymmetry as speed increases, while observing physiological responses during a O2maxtest. Data from athlete monitoring of 12 cross-country and triathlon athletes were analyzed. The athlete monitoring protocol included three unweighted countermovement jumps and a O2maxtest performed by the athletes. The athletes had an average O2maxof 53.4 ± 7.7 mL/kg/min, while their average vGRF ...


The Efficacy Of Extended-Release Eprinomectin For The Reduction Of Horn Flies, Face Flies, And Fecal Egg Counts Of Parasitic Nematodes In Replacement Beef Heifers, Sophia F. Landers May 2020

The Efficacy Of Extended-Release Eprinomectin For The Reduction Of Horn Flies, Face Flies, And Fecal Egg Counts Of Parasitic Nematodes In Replacement Beef Heifers, Sophia F. Landers

Animal Science Undergraduate Honors Theses

The purpose of this study was to evaluate the efficacy of extended-release eprinomectin against horn flies, face flies, and fecal egg counts of parasitic nematodes in crossbreed replacement beef heifers. Fifty-four heifers were randomly placed into three treatment groups (N=18 heifers/treatment). Group 1 was administered the labeled dosage of extended-release eprinomectin on day 0. Group 2 acted as the negative control. Group 3 received the anthelmintic injection once a quarter of the heifers in the group reached the threshold treatment level for horn flies (N=200 flies/animal; day 41). Nematode infections were measured via fecal egg counts ...


Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave Feb 2020

Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave

All Dissertations, Theses, and Capstone Projects

Many types of neurons act as multimodal signaling centers. Yet, we have only limited insight into the regulation and functional consequences of neuronal co-transmission. For example, dopamine (DA) neurons, whose degeneration causes motor deficits characteristic of Parkinson’s Diseases (PD), communicate with all their targets by DA but only a selective subset of their targets using GABA, Glutamate, and the secreted cell signaling protein Sonic Hedgehog (Shh). It is unknown whether Levo-dopamine (L-Dopa) induced dyskinesia (LIDs), a severely debilitating side effect of DA supplementation in PD, might appear because DA neuron targets are exposed to high DA- but low Shh- ...


Pertussis Resurgence In Europe: Incidence And Epidemiologic Cycles In Immunization Required And Non-Required Countries, Sheryl Ann Duquet Jan 2020

Pertussis Resurgence In Europe: Incidence And Epidemiologic Cycles In Immunization Required And Non-Required Countries, Sheryl Ann Duquet

Walden Dissertations and Doctoral Studies

Although pertussis vaccines have been available for over 7 decades, countries are experiencing a pertussis resurgence. This study sought to establish a relationship between the European pertussis immunization schedule designs (with and without the inclusion of adolescent boosters) and the immunization requirement (recommended or required), which potentially influences immunity waning, and thus the incidence rate and epidemiologic cycles of pertussis. The theoretical foundation for this study was the theory of herd immunity. A quantitative research method was used, supported by a secondary data source. The statistical analysis included the use of linear regression to evaluate the relationship between the requirement ...


Genetic And Functional Approaches To Understanding Autoimmune And Inflammatory Pathologies, Abbas Raza Jan 2020

Genetic And Functional Approaches To Understanding Autoimmune And Inflammatory Pathologies, Abbas Raza

Graduate College Dissertations and Theses

Our understanding of genetic predisposition to inflammatory and autoimmune diseases has been enhanced by large scale quantitative trait loci (QTL) linkage mapping and genome-wide association studies (GWAS). However, the resolution and interpretation of QTL linkage mapping or GWAS findings are limited. In this work, we complement genetic predictions for several human diseases including multiple sclerosis (MS) and systemic capillary leakage syndrome (SCLS) with genetic and functional data in model organisms to associate genes with phenotypes and diseases.

Focusing on MS, an autoimmune inflammatory disease of the central nervous system (CNS), we experimentally tested the effect of three of the GWAS ...


Theranostics For Antiretroviral Biodistribution And Pharmacokinetics, Brendan M. Ottemann Dec 2019

Theranostics For Antiretroviral Biodistribution And Pharmacokinetics, Brendan M. Ottemann

Theses & Dissertations

RATIONALE: Our laboratories birthed the field of human immunodeficiency virus (HIV) theranostics. The new field allows simultaneous detection (diagnostics) and treatment (therapeutic) for the identification, treatment and inevitable elimination of virus in cell and tissue compartments. By employing theranostics, antiretroviral drugs (ARVs) can be tracked in lymph nodes, gut, spleen and liver. Cellular viral reservoirs including CD4+ T cell populations and mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) along with subcellular endosomal structures can now be targeted for drug delivery bringing therapeutics to areas where virus replicates. The overarching idea rests in improving precision targeted ARV delivery. Bringing ...


Characterization Of The Effect Of Exercise Dose And Integrative Nonpharmacological Therapies In The Treatment Of Chronic Pain, Anna M. Polaski Dec 2019

Characterization Of The Effect Of Exercise Dose And Integrative Nonpharmacological Therapies In The Treatment Of Chronic Pain, Anna M. Polaski

Electronic Theses and Dissertations

Chronic pain includes debilitating conditions affecting large populations of people throughout the world. These diseases are further complicated by comorbid psychological disorders which make chronic pain conditions difficult to treat. Nonpharmacological treatment options have more recently become an important mainstay of effective therapies and are currently being used to supplement or replace traditional pharmacological treatment methods. Exercise-based therapies in particular are of interest due to their demonstrated success in reducing pain symptoms as well as improving psychological outcomes. Dose is an important factor in being able to effectively prescribe treatments in the context of specific exercise interventions and specific pain ...


Gingival Mscs Improve Bone Phenotype In Ovariectomy-Induced Osteoporosis Via Programmed Cell Death Pathway, Sultan Alghaithi Dec 2019

Gingival Mscs Improve Bone Phenotype In Ovariectomy-Induced Osteoporosis Via Programmed Cell Death Pathway, Sultan Alghaithi

Dental Theses

Estrogen deficiency-related osteoporosis is a skeletal system disorder that affects women after menopause taking a toll on financial and health institutions. Gingival Mesenchymal Stem cells (GMSCs) are a distinctive population of dental tissue-derived stem cells that possess uniquely high proliferation abilities and are capable of self-maintenance and multipotent differentiation. Their use has been investigated in different disease model applications, including cutaneous wound healing models, colitis, and allergy-related inflammatory disease models, but their effect on the bone phenotype of ovariectomy-induced osteoporosis hasn’t been explored. In our study, we show that a single systemic infusion of GMSCs elevated the bone mass ...


The Benefits Of Physical Activity And Sport On Mental Health And Well-Being In School-Aged Children, Ian Gilhousen Dec 2019

The Benefits Of Physical Activity And Sport On Mental Health And Well-Being In School-Aged Children, Ian Gilhousen

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

There is research that concludes that there are benefits of physical activity for young children. However, there is an area of research which is lacking the benefits that physical activity and sport have on mental health and well-being in school-aged children, specifically. Therefore, the purpose of this synthesis was to review the literature on the benefits of physical activity and sport on mental health and well-being in school-aged children. Results determined that there are significant benefits, and a correlation between physical activity participation and overall mental health in school-aged children.


Concussion Assessment Management In High School And Collegiate Athletics, Erin Mcneely Dec 2019

Concussion Assessment Management In High School And Collegiate Athletics, Erin Mcneely

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

Research indicates that protocol regarding concussion assessment management at the high school and collegiate level is advancing, however, there are holes in consistency that need to be filled in order to ensure accuracy. The purpose of this synthesis was to review the literature on concussion assessment management in high school and collegiate athletics. The results indicate that the lack of consistency comes as a direct result of key factors including a school’s lack of funding and lack of resources, the emphasis placed on the self-efficacy of athletic trainers, and the willingness of athletic trainers to follow guidelines provided for ...


Parents' Understanding Of The Impact On Sport Specialization, Samuel Lacelle Dec 2019

Parents' Understanding Of The Impact On Sport Specialization, Samuel Lacelle

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis project was to review the literature on parents’ understanding of the impact on sport specialization. An extensive literature review was completed in order to properly examine all the information available regarding the parent’s role when it comes to their child’s participation in sport and whether or not they are specializing in a specific sport. This review was done so by examining 16 peer reviewed articles on multiple web data bases. The research concluded that there should be a high emphasis on the child’s motor development at an early age (Goodway and Robinson ...


Barriers To Physical Activity In Adolescents, Nicole Vojtisek Dec 2019

Barriers To Physical Activity In Adolescents, Nicole Vojtisek

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

Abstract

Physical activity is an important component to living a healthy lifestyle; however, adolescents’ physical activity levels are often very low. Thus, the purpose of this synthesis was to examine barriers adolescents face when it comes to being physically active and find out how they can be prevented or overcome. The critical mass revealed several internal and external barriers that adolescents face. These include lack of motivation/interest, lack of resources, and increased screen time. Since the research is examining adolescents, parents also played a large role in the studies. In order to address some of the barriers, strategies focused ...


The Impact Of Performance Anxiety On Female Athletes, Nina Barbero Dec 2019

The Impact Of Performance Anxiety On Female Athletes, Nina Barbero

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis is to examine the impact of performance anxiety on female athletes. Articles reviewed were aimed at answering two questions, what are the major sources that contribute to performance anxiety, and how does anxiety impact female athletes. Delimiting variables were used to do an exhaustive data-based search which yielded 10 articles. The research studies synthesized through this project were analyzed with the goal of concluding about the impact of performance anxiety on female athletes. It was revealed that while females experience higher levels of cognitive anxiety compared to males, cognitive and somatic anxiety increases from training ...


Parent’S Perspectives Of Physical Activity Recreational Programs For Their Children With Disabilities, Scott Caracci Dec 2019

Parent’S Perspectives Of Physical Activity Recreational Programs For Their Children With Disabilities, Scott Caracci

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis was to examine parent's perspectives of physical activity recreational programs for their children with disabilities. The studies in the critical mass reviewed the different perceptions that parents relayed including benefits and positive outcomes such as, children being able to see themselves be successful and having their social skills increase as well as barriers to successful inclusion such as, not having the right equipment, not finding a program that works with their child or not being able to trust staff know how to appropriately work with their child. They also identified opportunities that could enhance ...


Positive Relationship Physical Activity Has On Cognitive Function In High School Students, Nicholas Zaccarella Dec 2019

Positive Relationship Physical Activity Has On Cognitive Function In High School Students, Nicholas Zaccarella

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

Research shows a link between physical activity and cognitive function. This connection sheds light on the idea that physical activity can improve cognitive function. Penning et al., (2017) mentions that adolescents have high levels of sedentary behavior which makes them vulnerable for health concerns. During the school day students spend most of their time sitting and staying at a resting heart rate. Vazou, Pesce, Lakes, and Smiley-Owen (2019) found consistent evidence that aerobic or motor skill physical activity, enhanced children’s spatial abilities and working memory. Many hours were spent searching through data bases to find articles on this topic ...


Physical Activity Patterns Of Students From Low-Socioeconomic Status, Elizabeth Johnson Dec 2019

Physical Activity Patterns Of Students From Low-Socioeconomic Status, Elizabeth Johnson

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

Research indicates that in today’s society, there is less and less physical activity happening amongst young children from low-socioeconomic households. The purpose of this synthesis was to review the literature on physical activity patterns and behaviors of children from low socioeconomic families. Teachers, families, and communities can have an impact on the lives of these children. Results indicate that there are ways we can increase physical activity and positive behaviors amongst low-socioeconomic youth.


Characterization Of The Nuclear Pore Complex In Red Alga, Cyanidioschyzon Merolae, Michelle Veronin Dec 2019

Characterization Of The Nuclear Pore Complex In Red Alga, Cyanidioschyzon Merolae, Michelle Veronin

Health and Kinesiology Theses

Cyanidioschyzon merolae (C. merolae) is a primitive, unicellular species of red alga that is considered to be one of the simplest self-sustaining eukaryotes. The highly elementary nature of C. merolae makes it an excellent model organism for studying evolution as well as cell function and organelle communication. In our study, we hypothesize that C. merolae contains the minimal assembly of proteins to make up their Nuclear Pore Complexes (NPCs), and hence are the first ancestral NPCs. NPCs are essential for basic nuclear transport in the cell. They are embedded in the double membrane of the nucleus, the nuclear envelope (NE ...


A Profile Of Physical Activity In The City Of Knoxville's Lonsdale Park, Carly Scot Eakin Dec 2019

A Profile Of Physical Activity In The City Of Knoxville's Lonsdale Park, Carly Scot Eakin

Chancellor’s Honors Program Projects

No abstract provided.


Investigating The Effects Of Excitotoxic Stimuli On The Suprachiasmatic Nucleus, Rachel A. Brandes Dec 2019

Investigating The Effects Of Excitotoxic Stimuli On The Suprachiasmatic Nucleus, Rachel A. Brandes

Chancellor’s Honors Program Projects

No abstract provided.


The Effects Of Physical Activity On Inappropriate Behaviors Of School-Aged Students With Autism Spectrum Disorders, Rachel Sherman Dec 2019

The Effects Of Physical Activity On Inappropriate Behaviors Of School-Aged Students With Autism Spectrum Disorders, Rachel Sherman

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

Abstract

The purpose of this synthesis was to examine the effects of physical activity on inappropriate behaviors of school-aged students with Autism Spectrum Disorders. Inappropriate behaviors can include: hitting, biting, screaming, kicking and swearing. In particular the following research questions were examined: What types of inappropriate behaviors are exhibited by students with Autism Spectrum Disorder during physical activity? Does physical activity help to eliminate or reduce inappropriate behaviors of students with Autism Spectrum Disorder during physical activity? Which forms of physical activity have demonstrated the most effective ways to eliminate or reduce inappropriate behaviors of students with Autism Spectrum Disorder ...


The Effects Of Peer Tutoring On School-Aged Students With Moderate To Severe Disabilities In Physical Education, Abbey Hume Dec 2019

The Effects Of Peer Tutoring On School-Aged Students With Moderate To Severe Disabilities In Physical Education, Abbey Hume

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis was to examine the existing scholarly knowledge regarding impact of peer tutoring programs on students with disabilities and typically developing students in physical education. Previous research identified several factors that contributed to the benefits and barriers of peer tutoring programs in physical education. Studies reviewed within the critical mass had common themes such as increase in socialization among students, engagement in activities, and improvement of skills. Common barriers that were discovered included, time consuming program, non-trained peer tutors, and peer tutors not participating in activities. Peer tutoring is an instructional strategy that is thought to ...


Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington Dec 2019

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Ulnar Collateral Ligament Reconstruction (UCLR) is a surgical procedure on one of the main ligaments that provides normal stability for the elbow joint against excessive valgus stress. Damage to this ligament is common in athletes performing overhead throwing activities, primarily baseball players, due to excessive valgus stress during the throwing motion. The most common form of treatment for this type of injury is reconstructive surgery of the ligament, especially if athletes wish to return to sport participation. This type of surgery is extremely invasive and requires extensive post-operative rehabilitation in order to facilitate return to play. To date, many ...


The Difference In A1c Of Children And Adolescents With Type 1 Diabetes Mellitus Using Carbohydrate Counting Compared To Those Using A Structured Meal Plan, Alia El Kubbe Nov 2019

The Difference In A1c Of Children And Adolescents With Type 1 Diabetes Mellitus Using Carbohydrate Counting Compared To Those Using A Structured Meal Plan, Alia El Kubbe

Electronic Thesis and Dissertation Repository

Carbohydrate counting (CHO) is a nutrition education tool used by patients with type 1 diabetes mellitus (T1DM). The primary objective was to assess glycated hemoglobin (A1C) in participants with T1DM using CHO counting vs. those using a structured meal plan (SMP). The secondary objectives were to determine if BMI-for-age, parental income, parental involvement, and mothers’ educational level were associated with their children’s glycemic control. A cross sectional study was conducted, where participants aged 4-18 years, or their parents completed a survey. Total sample size was 88 participants (77 in the CHO counting group and 11 in the SMP group ...


Recovery Following Proximal Humerus Fracture, Azar Varahrami Vigeh Nov 2019

Recovery Following Proximal Humerus Fracture, Azar Varahrami Vigeh

Electronic Thesis and Dissertation Repository

There is currently a glaring gap in the existing knowledge to address individuals’ experiences while recovering from a proximal humeral fracture (PHF). The main objective of this dissertation was to understand better how recovery is perceived by individuals after PHF. This overarching objective aligned well with the broad conceptualization of the issue at hand as those provided by the International Classification of Functioning, Disability and Health (ICF). Three inter-linked studies were conducted to provide a broader picture of recovery after PHF. The first study was a systematic review of prognostic factors predicting recovery after PHF in adults. This review demonstrated ...


Equine Hoof Stratum Internum K14+Cd105+ Progenitor Cells: Culture, Characterization, And Model Of Epithelial To Mesenchymal Transition, Qingqiu Yang Oct 2019

Equine Hoof Stratum Internum K14+Cd105+ Progenitor Cells: Culture, Characterization, And Model Of Epithelial To Mesenchymal Transition, Qingqiu Yang

LSU Doctoral Dissertations

For the potential benefit of progenitor cells to be realized in cell-based clinical therapies, it is vital to investigate the mechanism between progenitor cells and abnormal tissue formation. Laminitis is a fatal condition that is often presented by equine hoof inflammation and hoof tissue disarrangement. The persistence of abnormal tissue formation after the resolution of equine laminitis suggests there is progenitor cell compromise. So far, there is limited information about equine hoof progenitor cells and the effects of inflammation on hoof progenitor cells. To pursue a better understanding of both hoof progenitor cell and hoof growth as well as find ...


In Search Of Psychiatric Kinds: Natural Kinds And Natural Classification In Psychiatry, Nicholas Slothouber Oct 2019

In Search Of Psychiatric Kinds: Natural Kinds And Natural Classification In Psychiatry, Nicholas Slothouber

Electronic Thesis and Dissertation Repository

In recent years both philosophers and scientists have asked whether or not our current kinds of mental disorder—e.g., schizophrenia, depression, bipolar disorder—are natural kinds; and, moreover, whether or not the search for natural kinds of mental disorder is a realistic desideratum for psychiatry. In this dissertation I clarify the sense in which a kind can be said to be “natural” or “real” and argue that, despite a few notable exceptions, kinds of mental disorder cannot be considered natural kinds. Furthermore, I contend that psychopathological phenomena do not cluster together into kinds in the way that paradigmatic natural ...


The Barriers To Physical Activity For Individuals With Autism Spectrum Disorders And Strategies For Overcoming These Barriers, Bridgette Varin Oct 2019

The Barriers To Physical Activity For Individuals With Autism Spectrum Disorders And Strategies For Overcoming These Barriers, Bridgette Varin

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis is to examine the barriers to physical activity (PA) for individuals with Autism Spectrum Disorders (ASD) and strategies for overcoming these barriers. Individuals with ASD face more barriers to PA than their typically developing peers, and therefore, tend to lead less active lifestyles (Must et al., 2015). This can lead to limited motor coordination, health-related issues, and hypokinetic diseases for individuals with ASD (Case & Yun, 2015). The research studies synthesized through this project were analyzed in hopes of uncovering commonly cited barriers to PA for individuals with ASD and strategies for overcoming these barriers. Understanding ...


The Impact Of Extrinsic Motivation On Athletic Performance, Timothy Petranchuk Jr. Oct 2019

The Impact Of Extrinsic Motivation On Athletic Performance, Timothy Petranchuk Jr.

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

Youth participation in sports include recreational, organized, informal programs as well as Olympic hopefuls. These young athletes can have positive or negative experiences from their participation in sports. Perhaps an important aspect of what makes those experiences either positive or negative is how they are motivated to participate in these activities. Motivation in these young athletes can come in various ways. One main theme found in the literature that has a direct influence on their experiences is extrinsic motivation. It is important to understand how these athletes' performances are affected by outside influences, such as parents, coaches and peers. This ...


Eugenics In The 21st Century, Jessica Linn Chin Sep 2019

Eugenics In The 21st Century, Jessica Linn Chin

All Dissertations, Theses, and Capstone Projects

Eugenics is the science of enhancing the human population through the management of breeding and hereditary traits. This thesis explores the history of eugenics and shows how eugenic practices continue in the 21st century with advancements in technology and positive eugenic goals that can result in adverse effects on the human body and society. When Sir Francis Galton coined the term eugenics in 1883, he intended to improve British society with the use of positive eugenics. Galton used positive eugenics to encourage people with good mental and physical qualities to produce more children. He avoided negative eugenics, which involved ...