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Theses/Dissertations

Food Science

Doctoral Dissertations

Insulin resistance

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Imidacloprid, A Neonicotinoid Insecticide, Impairs Lipid And Glucose Metabolism, Quancai Sun Nov 2017

Imidacloprid, A Neonicotinoid Insecticide, Impairs Lipid And Glucose Metabolism, Quancai Sun

Doctoral Dissertations

Emerging evidence suggests that environmental pollutants, including insecticides, are linked to excessive weight gain and altered glucose homeostasis. However, there is currently limited knowledge regarding the biochemical mechanisms by which exposure to insecticides contribute to obesity and its associated pathologies. We first studied the influence of fipronil (a phenylpyrazole family insecticide) on 3T3-L1 adipogenesis. Recently imidacloprid, a neonicotinoid insecticide, was reported to potentiate adipogenesis and insulin resistance in vitro. The current studies also determined the effects of imidacloprid exposure and its interaction with dietary fat in the development of adiposity and insulin resistance using both male and female C57BL/6J ...


Effects Of Permethrin, A Pyrethroid Insecticide, On Glucose And Lipid Metabolism, Xiao Xiao Jul 2017

Effects Of Permethrin, A Pyrethroid Insecticide, On Glucose And Lipid Metabolism, Xiao Xiao

Doctoral Dissertations

Over the last few decades, the decline of using organochlorine and organophosphorus insecticides has partially contributed to the rising utilization of newer synthetic insecticides, which are considered as less harmful and more environmental friendly than the older generation of insecticides. Pyrethroid insecticides are one of the newer insecticide classes reported with better biodegradability and low mammalian toxicity without sacrificing its insecticidal efficacy. Permethrin is one of the most widely used pyrethroid insecticides with structural similarity with natural pyrethrin insecticide from the flowers of Chrysanthemum cinerariifolium. Since its introduction in the 1970’s, permethrin has been extensively used in medicine, military ...