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Theses/Dissertations

Food Science

Doctoral Dissertations

2019

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Effects Of Ivermectin And Perfluorobutanesulfonic Acid (Pfbs) On Lipid Metabolism, Weipeng Qi Oct 2019

Effects Of Ivermectin And Perfluorobutanesulfonic Acid (Pfbs) On Lipid Metabolism, Weipeng Qi

Doctoral Dissertations

Accumulating evidence has shown a link between environmental contaminants and altered lipid metabolism. There is currently, however, limited knowledge regarding the causal molecular mechanisms. Therefore, we investigated the molecular mechanisms of two environmental contaminants, ivermectin and perfluorobutanesulfonic acid (PFBS), on lipid metabolism in adipocytes and hepatocytes using cell culture models. We first studied the effects of ivermectin, an anti-parasitic agent, on the adipogenesis of 3T3-L1 preadipocytes. Our current results suggest that ivermectin inhibits adipogenesis in 3T3-L1 preadipocytes and the expression of adipogenic genes where these effects were found to be partially via PPARĪ³-dependent, but not FXR-dependent, pathway. Additionally, ivermectin also ...