Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 4 of 4

Full-Text Articles in Life Sciences

Biotransformation Of Resveratrol And Its Implications In Biological Activities In The Colon, Fang Li Nov 2018

Biotransformation Of Resveratrol And Its Implications In Biological Activities In The Colon, Fang Li

Doctoral Dissertations

Resveratrol (RES) is a natural polyphenol compound with a wide range of health-promoting activities, including protective effects against colon cancer and renal disease. However, the premise of these benefits has been dampened since RES shows a poor oral bioavailability due to its rapid and extensive biotransformation after oral consumption. The paradox (low bioavailability but high bioactivity) warrants further investigations to determine the contribution of RES metabolites to the health benefits associated with RES. We identified 11 metabolites of RES in mice with high-resolution HPLC-MS/MS, then quantified two major metabolites - dihydro-resveratrol (DHR) and lunularin (LUN). To further understand the chemopreventative ...


Combination Regimens Using Dietary Components For The Chemoprevention Of Colorectal Cancer And Inflammation, Christina Dimarco-Crook Nov 2018

Combination Regimens Using Dietary Components For The Chemoprevention Of Colorectal Cancer And Inflammation, Christina Dimarco-Crook

Doctoral Dissertations

ABSTRACT

COMBINATION REGIMENS USING DIETARY COMPONENTS FOR THE

CHEMOPREVENTION OF COLORECTAL CANCER

AND INFLAMMATION

September 2018

CHRISTINA DIMARCO-CROOK, B.S., IMMACULATA UNIVERSITY

M.S., DREXEL UNIVERSITY

Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST

Directed by: Professor Hang Xiao

Dietary components have been found to effectively modulate multiple deregulated signaling pathways associated with the initiation and progression of carcinogenesis and inflammation in cellular and animal models. However, clinical studies have shown mixed results when examining the efficacy of individual dietary components, perhaps suggestive of the synergism that exists between multiple components within a particular food and the diet as a whole. Additional ...


Interaction Between Dietary Components And Gut Microbiota And Its Implication In Bioactivities And Metabolism In Colon, Min Gu Oct 2018

Interaction Between Dietary Components And Gut Microbiota And Its Implication In Bioactivities And Metabolism In Colon, Min Gu

Doctoral Dissertations

The microbial cells that colonize the human body, including mucosal and skin environments, are at least as abundant as our somatic cells and certainly contain far more genes than our human genome. Gut microbiota dysbiosis is associated with the onset and progress of several diseases, like diabetes, obesity, inflammatory bowel disease. One of the environmental factor-diet intervention can modulate the compositions of gut microbiota, which in turn may contribute to altered health outcomes such as changes in the risks of chronic diseases. Orange peel has been a traditional herb in China, and some of its compounds has shown health benefits ...


In Situ And Real-Time Monitoring And Characterization Of Pesticide Residues On And In Fresh Produce Using Sers, Tianxi Yang Jul 2018

In Situ And Real-Time Monitoring And Characterization Of Pesticide Residues On And In Fresh Produce Using Sers, Tianxi Yang

Doctoral Dissertations

Understanding of the behavior and fate of pesticides in fresh produce is of great significance for effectively applying pesticides and minimizing pesticide residues in food. There is lack, however, of an effective method that can monitor and characterize pesticide behaviors including penetration, persistence and translocation. Herein, we developed a novel method for real-time and in situ monitoring of pesticide behaviors in fresh produce based on surface-enhanced Raman scattering (SERS) mapping method. Taking advantage of penetrative gold nanoparticles as probes to enhance the internalized pesticide signals, the internal signals from pesticides were successfully obtained in situ. We found that systemic pesticides ...