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Theses/Dissertations

Food Science

Doctoral Dissertations

2017

Anticancer Anti-inflammation Antioxidant Combination Allyl isothiocyanate Sulforaphane Luteolin Curcumin

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Potential Enhancement Of Dietary Isothiocyanates Combination On Biological Activities, Kanyasiri Rakariyatham Jul 2017

Potential Enhancement Of Dietary Isothiocyanates Combination On Biological Activities, Kanyasiri Rakariyatham

Doctoral Dissertations

Isothiocyanates (ITCs) such as allyl isothiocyanate (AIT) and sulforaphane (SFN) are well-known bioactives with wide range of beneficial properties, which may be consumed simultaneously through diets containing cruciferous vegetables. However, biological activities of ITCs in combinations had not been well defined. The present study evaluated the potential efficacy of AIT, SFN and their combinations on three important biological properties: anticancer, anti-inflammation and antioxidant.

Our results showed that the combination between AIT and SFN led to a stronger growth inhibition on A549 non-small cell lung cancer cells than treatments with the individual compounds. The enhanced effect was proved to be synergistic ...