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Full-Text Articles in Life Sciences

Imidacloprid, A Neonicotinoid Insecticide, Impairs Lipid And Glucose Metabolism, Quancai Sun Nov 2017

Imidacloprid, A Neonicotinoid Insecticide, Impairs Lipid And Glucose Metabolism, Quancai Sun

Doctoral Dissertations

Emerging evidence suggests that environmental pollutants, including insecticides, are linked to excessive weight gain and altered glucose homeostasis. However, there is currently limited knowledge regarding the biochemical mechanisms by which exposure to insecticides contribute to obesity and its associated pathologies. We first studied the influence of fipronil (a phenylpyrazole family insecticide) on 3T3-L1 adipogenesis. Recently imidacloprid, a neonicotinoid insecticide, was reported to potentiate adipogenesis and insulin resistance in vitro. The current studies also determined the effects of imidacloprid exposure and its interaction with dietary fat in the development of adiposity and insulin resistance using both male and female C57BL/6J ...


A Transcriptomic Analysis Of Salmonella Enterica Newport In Planta And After Postharvest Sanitization, Laurel Lynn Dunn Aug 2017

A Transcriptomic Analysis Of Salmonella Enterica Newport In Planta And After Postharvest Sanitization, Laurel Lynn Dunn

Doctoral Dissertations

The consumption of fresh produce is increasingly linked to incidence of foodborne illness. Pathogens including Salmonella enterica, Shiga toxigenic Escherichia coli, and Listeria monocytogenes are exposed to produce crops through direct human or animal contact, contaminated agricultural water, bioaerosols, run-off, and improperly treated compost. S. enterica has demonstrated exceptional tolerance to the stresses encountered in the environment, on plant tissue, and from postharvest antimicrobial mitigation strategies. Understanding the transcriptomic mechanisms S. enterica employs to survive these hazards is integral for the development of more effective preventive controls and post-harvest steps to prevent the pathogen from infecting consumers.


Understanding The Impact Of Oxygen Concentration And Active Packaging On Controlling Lipid Oxidation In Oil-In-Water Emulsions, David Johnson Jul 2017

Understanding The Impact Of Oxygen Concentration And Active Packaging On Controlling Lipid Oxidation In Oil-In-Water Emulsions, David Johnson

Doctoral Dissertations

Consumer concern over synthetic food antioxidants have led researchers to seek alternative natural, or ‘clean’ label, solutions to prevent lipid oxidation. Unfortunately, natural antioxidants are often not as effective as their synthetic counterparts. As a result, there remains a need to develop active packaging strategies and maximize current antioxidant strategies in food applications.

Active packaging, or packaging that has a function beyond being an inert barrier, is an attractive strategy to limit lipid oxidation in foods. Active packaging performs the work of an antioxidant without appearing on the package label. The work presented here builds upon active packaging development as ...


Utilization Of Natural Emulsifiers And Their Derivatives To Formulate Emulsion-Based Delivery Systems For Hydrophobic Nutraceuticals, Cansu Gumus Jul 2017

Utilization Of Natural Emulsifiers And Their Derivatives To Formulate Emulsion-Based Delivery Systems For Hydrophobic Nutraceuticals, Cansu Gumus

Doctoral Dissertations

There is increasing consumer demand for food products that are more natural, sustainable, and environmentally friendly. Industry has responded by trying to identify natural alternatives to synthetic functional ingredients within these products. In this study, the ability of Maillard conjugation products, and several legume proteins were investigated to act as nature-derived or natural emulsifiers in oil-in-water emulsions fortified with hydrophobic nutraceuticals.

Casein-coated oil droplets enriched with lutein were highly unstable to flocculation near their isoelectric point due to the reduction in electrostatic repulsion. However, casein-dextran-coated droplets were stable, which was attributed to strong steric repulsion by the dextran moiety. The ...


Effects Of Permethrin, A Pyrethroid Insecticide, On Glucose And Lipid Metabolism, Xiao Xiao Jul 2017

Effects Of Permethrin, A Pyrethroid Insecticide, On Glucose And Lipid Metabolism, Xiao Xiao

Doctoral Dissertations

Over the last few decades, the decline of using organochlorine and organophosphorus insecticides has partially contributed to the rising utilization of newer synthetic insecticides, which are considered as less harmful and more environmental friendly than the older generation of insecticides. Pyrethroid insecticides are one of the newer insecticide classes reported with better biodegradability and low mammalian toxicity without sacrificing its insecticidal efficacy. Permethrin is one of the most widely used pyrethroid insecticides with structural similarity with natural pyrethrin insecticide from the flowers of Chrysanthemum cinerariifolium. Since its introduction in the 1970’s, permethrin has been extensively used in medicine, military ...


Potential Enhancement Of Dietary Isothiocyanates Combination On Biological Activities, Kanyasiri Rakariyatham Jul 2017

Potential Enhancement Of Dietary Isothiocyanates Combination On Biological Activities, Kanyasiri Rakariyatham

Doctoral Dissertations

Isothiocyanates (ITCs) such as allyl isothiocyanate (AIT) and sulforaphane (SFN) are well-known bioactives with wide range of beneficial properties, which may be consumed simultaneously through diets containing cruciferous vegetables. However, biological activities of ITCs in combinations had not been well defined. The present study evaluated the potential efficacy of AIT, SFN and their combinations on three important biological properties: anticancer, anti-inflammation and antioxidant.

Our results showed that the combination between AIT and SFN led to a stronger growth inhibition on A549 non-small cell lung cancer cells than treatments with the individual compounds. The enhanced effect was proved to be synergistic ...