Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

PDF

Food Science

Food Science and Human Nutrition Publications

Department of Veterinary Diagnostic and Production Animal Medicine

Publication Year

Articles 1 - 3 of 3

Full-Text Articles in Life Sciences

Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed To Swine, Guillermo Fernandez-Surumay, Gary D. Osweiler, Michael J. Yaeger, George E. Rottinghaus, Suzanne Hendrich, Lucas K. Buckley, Patricia A. Murphy Apr 2005

Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed To Swine, Guillermo Fernandez-Surumay, Gary D. Osweiler, Michael J. Yaeger, George E. Rottinghaus, Suzanne Hendrich, Lucas K. Buckley, Patricia A. Murphy

Food Science and Human Nutrition Publications

The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 µmol of total fumonisin B/kg (FB), 528 µmol of total FB-glucose adducts/kg (FB-G, 122 µmol of unreacted FB/kg), or 0 µmol of total FB/kg for 15 days to test the efficacy of the FB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls, which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control ...


Glucose Reaction With Fumonisin B1 Partially Reduces Its Toxicity In Swine, Guillermo Fernandez-Surumay, Gary D. Osweiler, Michael Yaeger, Catherine C. Hauck, Suzanne Hendrich, Patricia A. Murphy Nov 2004

Glucose Reaction With Fumonisin B1 Partially Reduces Its Toxicity In Swine, Guillermo Fernandez-Surumay, Gary D. Osweiler, Michael Yaeger, Catherine C. Hauck, Suzanne Hendrich, Patricia A. Murphy

Food Science and Human Nutrition Publications

Acute and subacute intraperitoneal doses of fumonisin B1 (FB1) were administered to test the efficacy of the FB1-glucose reaction products in detoxifying FB1 in swine. In the acute study at 11 µmol of FB1/kg of body weight, five of six pigs administered FB1 and four of six pigs administered FB1- glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate aminotransferase and γ-glutamyltransferase, total cholesterol, and pathological evaluation did not provide evidence of protection against FB1 toxicity by the FB1-glucose reaction products. In the subacute study at 5.5 µmol of FB1/kg of body weight, one ...


Characterization Of Fumonisin B1-Glucosereaction Kinetics And Products, Yun Lu, Laura Clifford, Catherine C. Hauck, Suzanne Hendrich, Gary Osweiler, Patricia A. Murphy Jun 2002

Characterization Of Fumonisin B1-Glucosereaction Kinetics And Products, Yun Lu, Laura Clifford, Catherine C. Hauck, Suzanne Hendrich, Gary Osweiler, Patricia A. Murphy

Food Science and Human Nutrition Publications

The reaction of fumonisin B1 with the reducing sugar D-glucose can block the primary amine group of fumonisin B1 and may detoxify this mycotoxin. A method to separate hundred milligram quantities of fumonisin B1-glucose reaction products from the excess D-glucose with a reversed-phase C18 cartridge was developed. Mass spectrometry revealed that there were four primary products in this chain reaction when fumonisin B1 was heated with D-glucose at 65 C for 48 h: N-methyl-fumonisin B1, N-carboxymethyl-fumonisin B1, N-(3-hydroxyacetonyl)-fumonisin B1, and N-(2-hydroxy, 2-car- boxyethyl)-fumonisin B1. The N-(1-deoxy-D-fructos-1-yl) fumonisin B1 (fumonisin B1-glucose Schiff’s base) was detected ...