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Articles 361 - 390 of 450

Full-Text Articles in Life Sciences

A New Pharmacological Agent (Akb-4924) Stabilizes Hypoxia Inducible Factor (Hif) And Increases Skin Innate Defenses Against Bacterial Infection., Cheryl Okumura, A. Hollands, D. Tran, J. Olson, S. Dahesh, M. Von KöCkritz-Blickwede, W. Thienphrapa, C. Corle, S. Jeung, A. Kotsakis, R. Shalwitz, R. Johnson, V. Nizet Aug 2012

A New Pharmacological Agent (Akb-4924) Stabilizes Hypoxia Inducible Factor (Hif) And Increases Skin Innate Defenses Against Bacterial Infection., Cheryl Okumura, A. Hollands, D. Tran, J. Olson, S. Dahesh, M. Von KöCkritz-Blickwede, W. Thienphrapa, C. Corle, S. Jeung, A. Kotsakis, R. Shalwitz, R. Johnson, V. Nizet

Cheryl Okumura

Hypoxia inducible factor-1 (HIF-1) is a transcription factor that is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress. HIF-1 is also activated in response to bacterial pathogens and supports the innate immune response of both phagocytes and keratinocytes. In this work, we show that a new pharmacological compound AKB-4924 (Akebia Therapeutics) increases HIF-1α levels and enhances the antibacterial activity of phagocytes and keratinocytes against both methicillin-sensitive and -resistant strains of Staphylococcus aureus in vitro. AKB-4924 is also effective in stimulating the killing capacity of keratinocytes against the important opportunistic skin pathogens Pseudomonas aeruginosa and Acinitobacter ...


Novel Role Of The Transcription Factor Hif-1Α In The Formation Of Mast Cell Extracellular Traps., K. Branitzki-Heinemann, Cheryl Okumura, L. VöLlger, Y. Kawakami, T. Kawakami, H. Naim, V. Nizet, M. Von KöCkritz-Blickwede Aug 2012

Novel Role Of The Transcription Factor Hif-1Α In The Formation Of Mast Cell Extracellular Traps., K. Branitzki-Heinemann, Cheryl Okumura, L. VöLlger, Y. Kawakami, T. Kawakami, H. Naim, V. Nizet, M. Von KöCkritz-Blickwede

Cheryl Okumura

MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).


Cosmic Ray Particles Images With Orca-Ii Erg, George Mcnamara Aug 2012

Cosmic Ray Particles Images With Orca-Ii Erg, George Mcnamara

George McNamara

Cosmic ray particles image series acquired using a Hamamatsu ORCA-II ERG scientific grade CCD camera, cooled to -60 C. Each image is a consecutive 600 second (10 minute) exposure time with no light to the camera.

While processing the data, I discoverd that the background changed around planes 25 and 227 (see Excel file and jpeg screenshots), so I also processed only planes 025-227 (203 planes total, 2030 minutes, 33.83 hours). the CCD industry "rule of thumb" for a "typical" CCD sensor (i.e. 1/3" CCD) is that one cosmic ray particle strikes a sensor approximately every 30 ...


Trace Elements Affect Methanogenic Activity And Diversity In Enrichments From Subsurface Coal Bed Produced Water, B. Unal, V. R. Perry, M. Sheth, V. Gomez-Alvarez, K. J. Chin, Klaus R. Nusslein May 2012

Trace Elements Affect Methanogenic Activity And Diversity In Enrichments From Subsurface Coal Bed Produced Water, B. Unal, V. R. Perry, M. Sheth, V. Gomez-Alvarez, K. J. Chin, Klaus R. Nusslein

Klaus R. Nusslein

Microbial methane from coal beds accounts for a significant and growing percentage of natural gas worldwide. Our knowledge of physical and geochemical factors regulating methanogenesis is still in its infancy. We hypothesized that in these closed systems, trace elements (as micronutrients) are a limiting factor for methanogenic growth and activity. Trace elements are essential components of enzymes or cofactors of metabolic pathways associated with methanogenesis. This study examined the effects of eight trace elements (iron, nickel, cobalt, molybdenum, zinc, manganese, boron, and copper) on methane production, on mcrA transcript levels, and on methanogenic community structure in enrichment cultures obtained from ...


Clay Fabric And Mass Physical Properties Of Surficial Marine Sediment Near The Deepwater Horizon Oil Spill, Andrew Head, Richard H. Bennett, Jessica R. Douglas, Kenneth J. Curry Feb 2012

Clay Fabric And Mass Physical Properties Of Surficial Marine Sediment Near The Deepwater Horizon Oil Spill, Andrew Head, Richard H. Bennett, Jessica R. Douglas, Kenneth J. Curry

Kenneth J. Curry

Surficial sediment was obtained on the RV Cape Hatteras Cruise (2010) from the seafloor at a water depth of 1570 meters located at latitude 28°44'20.16"N and longitude 88°20'24.96"W in close proximity to the Deepwater Horizon well, Gulf of Mexico. Preliminary clay nano- and microfabric observation using a transmission electron microscope (TEM) depicted a sediment rich in clays and organic matter (OM) especially in the upper 2 cm subbottom. Initial analysis of TEM micrographs depicted a high porosity clay sediment. Initial study of the mass physical properties revealed water content ωt = 67.32 ...


Pubspectra - Open Data Access Fluorescence Spectra, George Mcnamara Feb 2012

Pubspectra - Open Data Access Fluorescence Spectra, George Mcnamara

George McNamara

The Internet is enabling greater access to spectral imaging publications, spectral graphs, and data than that was available a generation ago. The spectral imaging systems discussed in this issue of Cytometry work because reagent and hardware spectra are reproducible, reusable, and provide input to spectral unmixing and spectral components recognition algorithms. These spectra need to be readily available in order to determine what to purchase, how to use it, and what the output means. We refer to several commercially sponsored and academic spectral web sites and discuss our spectral graphing and data sites. Sites include fluorescent dye graph servers from ...


Mcnamara 2011 Feature Extraction (Image Analysis), George Mcnamara Feb 2012

Mcnamara 2011 Feature Extraction (Image Analysis), George Mcnamara

George McNamara

Feature Extraction presentation and movies in a ZIP file from a presentation I gave at ISAC 2011 in Baltomore, Md.

Feature extraction is one phrase for image analysis.


Holyoke Dam, Connecticut River, 2012, Brett Towler Jan 2012

Holyoke Dam, Connecticut River, 2012, Brett Towler

Fish Passage Data Archive

Holyoke Dam

Connecticut River

Massachusetts

Year data collected: 2012


Conformations Of The Apo-, Substrate-Bound And Phosphate-Bound Atp-Binding Domain Of The Cu(Ii) Atpase Copb Illustrate Coupling Of Domain Movement To The Catalytic Cycle, José Argüello, Samuel Jayakanthan, Sue Roberts, Andrzej Weichsel, Megan Mcevoy Dec 2011

Conformations Of The Apo-, Substrate-Bound And Phosphate-Bound Atp-Binding Domain Of The Cu(Ii) Atpase Copb Illustrate Coupling Of Domain Movement To The Catalytic Cycle, José Argüello, Samuel Jayakanthan, Sue Roberts, Andrzej Weichsel, Megan Mcevoy

José M. Argüello

Heavy metal P1B-type ATPases play a critical role in cell survival by maintaining appropriate intracellular metal concentrations. Archaeoglobus fulgidus CopB is a member of this family that transports Cu(II) from the cytoplasm to the exterior of the cell using ATP as energy source. CopB has a 264 amino acid ATPBD (ATP-binding domain) that is essential for ATP binding and hydrolysis as well as ultimately transducing the energy to the transmembrane metal-binding site for metal occlusion and export. The relevant conformations of this domain during the different steps of the catalytic cycle are still under discussion. Through crystal structures of ...


Pharmacological Inhibition Of The Clpxp Protease Increases Bacterial Susceptibility To Host Cathelicidin Antimicrobial Peptides And Cell-Envelope Active Antibiotics., S. Mcgillivray, D. Tran, N. Ramadoss, J. Alumasa, Cheryl Okumura, G. Sakoulas, M. Vaughn, D. Zhang, K. Keiler, V. Nizet Dec 2011

Pharmacological Inhibition Of The Clpxp Protease Increases Bacterial Susceptibility To Host Cathelicidin Antimicrobial Peptides And Cell-Envelope Active Antibiotics., S. Mcgillivray, D. Tran, N. Ramadoss, J. Alumasa, Cheryl Okumura, G. Sakoulas, M. Vaughn, D. Zhang, K. Keiler, V. Nizet

Cheryl Okumura

The ClpXP protease is a critical bacterial intracellular protease that regulates protein turnover in many bacterial species. Here we identified a pharmacological inhibitor of the ClpXP protease, F2, and evaluated its action in Bacillus anthracis and Staphylococcus aureus. We found that F2 exhibited synergistic antimicrobial activity with cathelicidin antimicrobial peptides and antibiotics that target the cell well and/or cell membrane such as penicillin and daptomycin in B. anthracis and drug resistant strains of S. aureus. ClpXP inhibition represents a novel therapeutic strategy to simultaneously sensitize pathogenic bacteria to host defenses and pharmaceutical antibiotics.


Does Weather Or Site Characteristics Influence The Ability Of Scavengers To Locate Food?, Rebekah E. Ruzicka, Michael R. Conover Dec 2011

Does Weather Or Site Characteristics Influence The Ability Of Scavengers To Locate Food?, Rebekah E. Ruzicka, Michael R. Conover

Wildland Resources Faculty Publications

Olfactory predators and scavengers rely on odors to locate food, and they forage primarily at night. We hypothesized that weather (e.g. wind speed, humidity, and temperature), vegetation, and landscape features affect the dissipation of odors in the atmosphere and, thus, impact the foraging efficiency of olfactory predators. We tested this hypothesis by assessing what conditions were correlated with the persistence of bait along the dike surrounding Willard Bay Reservoir, Utah. We distributed 124 chicken eggs and 199 dead European starlings (Sturnus vulgaris) as bait over 21 separate occasions spanning from May 21, 2009, to August 18, 2009. We used ...


Erratum For "Inhibition Of Nitric Oxide Synthase By Cobalamins And Cobinamides," [Free Radic. Biol. Med. 46:1626–1632, 2009], J. Brice Weinberg, Youwei Chen, Ning Jiang, John C. Salerno, Dipak K. Ghosh Oct 2011

Erratum For "Inhibition Of Nitric Oxide Synthase By Cobalamins And Cobinamides," [Free Radic. Biol. Med. 46:1626–1632, 2009], J. Brice Weinberg, Youwei Chen, Ning Jiang, John C. Salerno, Dipak K. Ghosh

Faculty Publications

No abstract provided.


Effects Of Large-Scale Removal Of Coyotes On Pronghorn And Mule Deer Productivity And Abundance, Dylan E. Brown, Michael R. Conover May 2011

Effects Of Large-Scale Removal Of Coyotes On Pronghorn And Mule Deer Productivity And Abundance, Dylan E. Brown, Michael R. Conover

Wildland Resources Faculty Publications

We tested the hypothesis that predation by coyotes (Canis latrans) impacts pronghorn (Antilocapra americana) and mule deer (Odocoileus hemionus) populations. We did so by examining the effects of coyote removal on pronghorn and mule deer populations within 12 large areas (>10,500 km2) located in Wyoming and Utah during 2007 and 2008. Pronghorn productivity (fawn to adult female ratio) and abundance were positively correlated with the number of coyotes removed and removal effort (hours spent hunting coyotes from aircraft) although the correlation between pronghorn productivity and removal effort was not statistically significant (P = 0.08). Mule deer productivity and abundance ...


Examining Trends In Taste Preferences, Market Demand, And Annual Catch In An Indigenous Marine Turtle Fishery In Southwest Madagascar, Kristin Jones Apr 2011

Examining Trends In Taste Preferences, Market Demand, And Annual Catch In An Indigenous Marine Turtle Fishery In Southwest Madagascar, Kristin Jones

Independent Study Project (ISP) Collection

The worldwide exploitation of marine turtles has been common throughout human history, turtle products including carapaces for decoration and use, skin for leather, and eggs and meat for consumption. The hunting of marine turtles has long established economic importance among Madagascar's coastal inhabitants and is an activity traditionally associated with integral cultural and spiritual values. Due to overexploitation and a combination of relatively newer threats such as pollution, habitat loss, and incidental fisheries take, however, all marine turtle species in the Indian Ocean are considered to be endangered or critically endangered. Although Madagascar's marine turtles have been legally ...


Procambarus Clarkii Sarcoplasmic Calcium-Binding Protein Variant A (Scp1) Mrna, Complete Cds, M. J. Northcutt, Christopher M. Gillen Feb 2011

Procambarus Clarkii Sarcoplasmic Calcium-Binding Protein Variant A (Scp1) Mrna, Complete Cds, M. J. Northcutt, Christopher M. Gillen

Christopher M. Gillen

File name: JF692202.gb
Accession ID: JF692202
Molecule type: DNA
Sequence length: 740
Organism: Procambarus clarkii
Lineage: Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Astacidea > Astacoidea > Cmbaridae > Procambarus
Gene: SCP1
Database: GenBank


Procambarus Clarkii Sarcoplasmic Calcium-Binding Protein Variant B (Scp1) Mrna, Complete Cds, Christopher M. Gillen, M. J. Northcutt Feb 2011

Procambarus Clarkii Sarcoplasmic Calcium-Binding Protein Variant B (Scp1) Mrna, Complete Cds, Christopher M. Gillen, M. J. Northcutt

Christopher M. Gillen

File name: JF692203.gb Accession ID: JF692203
Molecule type: DNA
Sequence length: 740
Organism: Procambarus clarkii
Lineage: Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Astacidea > Astacoidea > Cambaridae > Procambarus
Gene: SCP1
Database: GenBank


Procambarus Clarkii Sarcoplasmic Calcium-Binding Protein Variant C (Scp1) Mrna, Complete Cds, Christopher M. Gillen, M. J. Northcutt Feb 2011

Procambarus Clarkii Sarcoplasmic Calcium-Binding Protein Variant C (Scp1) Mrna, Complete Cds, Christopher M. Gillen, M. J. Northcutt

Christopher M. Gillen

File name: JF692204.gb
Accession ID: JF692204
Molecule type: DNA
Sequence length: 740
Organism: Procambarus clarkii
Lineage: Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Astacidea > Astacoidea > Cambaridae > Procambarus
Gene: SCP1
Database: GenBank


Holyoke Dam, Connecticut River, 2011, Brett Towler Jan 2011

Holyoke Dam, Connecticut River, 2011, Brett Towler

Fish Passage Data Archive

Holyoke Dam

Connecticut River

Massachusetts

Year data collected: 2011


Software For Assumption Weighting For Meta-Analysis Of Genomic Data, Debashis Ghosh, Yihan Li Jan 2011

Software For Assumption Weighting For Meta-Analysis Of Genomic Data, Debashis Ghosh, Yihan Li

Debashis Ghosh

This is the software that accompanies Li and Ghosh, "Assumption weighting for incorporating heterogeneity into meta-analysis of genomic data."


European Red Mite Panonychus Ulmi, Diane G. Alston, Michael E. Reding Jan 2011

European Red Mite Panonychus Ulmi, Diane G. Alston, Michael E. Reding

All Archived Publications

No abstract provided.


Population Growth And Movements Of Canada Geese In New Haven, Connecticut During A 25-Year History, Michael R. Conover Jan 2011

Population Growth And Movements Of Canada Geese In New Haven, Connecticut During A 25-Year History, Michael R. Conover

Wildland Resources Faculty Publications

In the last few decades, Canada Geese (Branta canadensis) have become established in metropolitan areas throughout North America. From 1984 through 2009, Canada Geese in New Haven County, Connecticut, were banded as goslings (HY geese) and adults (AHY), and their movements and recruitment into the local breeding population were documented. During this period, the number of Canada Geese increased several fold in Connecticut. Geese were non-migratory; most recoveries (85%) of banded Canada Geese came from Connecticut, and 76% came from New Haven County. Dispersal rates outside of Connecticut peaked during 1990–1994 when 23% of all reported geese were shot ...


Ecoweb 1.1: Ecologists' Cooperative Web Bank, Joel E. Cohen Dec 2010

Ecoweb 1.1: Ecologists' Cooperative Web Bank, Joel E. Cohen

Cohen Laboratory

ECOWeB is a machine-readable database of several hundred food webs compiled from published sources by several ecologists.


Longleaf.Exe, Curtis Vanderschaaf Sep 2010

Longleaf.Exe, Curtis Vanderschaaf

Curtis VanderSchaaf

longleaf


Food Habits Of Wintering Waterfowl On The Great Salt Lake, Utah, Josh L. Vest, Michael R. Conover Jun 2010

Food Habits Of Wintering Waterfowl On The Great Salt Lake, Utah, Josh L. Vest, Michael R. Conover

Wildland Resources Faculty Publications

Two invertebrates, brine shrimp (Artemia franciscana) and brine flies (Ephydridac), occur in great densities in the Great Salt Lake (GSL) but it is unknown whether ducks forage extensively on them during winter or rely on freshwater food. Common Goldeneye (Bucephala clangula), Northern Shoveler (Anas clypeala) and Green-winged Teal (Anas crecca) were collected from the GSL during winters 2004–05 and 2005–06 to evaluate their food habits. Brine shrimp and brine flies comprised more than 70% of the winter diet of these ducks. Common Goldeneyes consumed mainly brine fly larvae (68% based on dry weight biomass), which live primarily along ...


Holyoke Dam, Connecticut River, 2010, Brett Towler Jan 2010

Holyoke Dam, Connecticut River, 2010, Brett Towler

Fish Passage Data Archive

Holyoke Dam

Connecticut River

Massachusetts

Year data collected: 2010


Flying Squirrel Removal Does Not Reduce Their Use Of Simulated Red-Cockaded Woodpecker Nest Cluster, Jennifer S. Borgo, Michael R. Conover, L. Michael Conner Jan 2010

Flying Squirrel Removal Does Not Reduce Their Use Of Simulated Red-Cockaded Woodpecker Nest Cluster, Jennifer S. Borgo, Michael R. Conover, L. Michael Conner

Wildland Resources Faculty Publications

Reproductive success of the endangered Picoides borealis (Red-cockaded Woodpecker) is thought to be reduced by the presence of Glaucomys volans (Southern Flying Squirrels); hence, these squirrels are often removed when found inside woodpecker cavities. For this management practice to benefit Red-cockaded Woodpeckers, however, squirrel removal must both reduce the future probability of a flying squirrel re-occupying cavities and increase reproductive success for Red-cockaded Woodpeckers. In this study, using simulated Red-cockaded Woodpecker clusters (pseudo-clusters), we tested the first assumption regarding squirrels reoccupying nest cavities. We found no differences between removal and control pseudo-clusters in the amount of time that flying squirrels ...


Scared Sick? Predator-Pathogen Facilitation Enhances The Exploitation Of A Shared Resource, R A. Ramirez, W E. Snyder Oct 2009

Scared Sick? Predator-Pathogen Facilitation Enhances The Exploitation Of A Shared Resource, R A. Ramirez, W E. Snyder

Biology Faculty Publications

Resource use generally increases with greater consumer diversity, an effect often attributed to resource partitioning. Pathogens and predators are two classes of consumer that exhibit differences in ecologically important traits (e.g., size, resource acquisition strategy, foraging location) that could lead to complementary effects on shared prey/hosts. To examine this possibility, we manipulated diversity among a community of predators and pathogens that together attack an herbivorous beetle, Leptinotarsa decemlineata, and measured resulting effects on herbivore suppression and resulting plant damage. We found that herbivore mortality increased, and plant damage decreased, when more natural enemy species were present. However, closer ...


Energy Budgets Of Eared Grebes On The Great Salt Lake And Implications For Harvest Of Brine Shrimp, Michael R. Conover, Joe N. Caudell Sep 2009

Energy Budgets Of Eared Grebes On The Great Salt Lake And Implications For Harvest Of Brine Shrimp, Michael R. Conover, Joe N. Caudell

Wildland Resources Faculty Publications

About 1.5-million eared grebes (Podiceps nigricollis), representing half of the North American population, stage on Utah's Great Salt Lake, USA (GSL) during autumn migration to forage on brine shrimp (Artemia franciscana). Indirectly competing with birds for brine shrimp are commercial harvesters who annually collect >1 million kg (dry wt) of shrimp cysts (i.e., hardened eggs), an amount that during some years equals up to half of all brine shrimp cysts produced annually on the GSL. No information was available regarding what impact this commercial harvest was having on eared grebes. We determined daily energy requirements of eared ...


Concentrations Of Selenium And Mercury In Eared Grebes (Podiceps Nigricollis) From Utah’S Great Salt Lake, Usa, Michael R. Conover, Josh L. Vest Jun 2009

Concentrations Of Selenium And Mercury In Eared Grebes (Podiceps Nigricollis) From Utah’S Great Salt Lake, Usa, Michael R. Conover, Josh L. Vest

Wildland Resources Faculty Publications

We examined selenium and mercury concentrations in eared grebes (Podiceps nigricollis) that spent the fall of 2006 on the Great Salt Lake (UT, USA), where their diet consisted mainly of brine shrimp (Artemia franciscana). Selenium concentrations in livers varied based on when the grebes were collected (lower in September [mean ± standard error, 9.4 ± 0.7 μg/g dry wt] than in November [14.5 ± 1.4 μg/g]), on where the birds were collected on the Great Salt Lake (Antelope Island, 8.6 ± 0.5 μg/g; Stansbury Island, 15.2 ± 1.4 μg/g), and on the grebe ...


Do Sharp-Tailed Grouse Select Loafing Sites To Avoid Visual Or Olfactory Predators?, Michael R. Conover, Jennifer S. Borgo Feb 2009

Do Sharp-Tailed Grouse Select Loafing Sites To Avoid Visual Or Olfactory Predators?, Michael R. Conover, Jennifer S. Borgo

Wildland Resources Faculty Publications

Grouse should seek loafing sites hidden from predators; however, good hiding sites from predators that use vision to locate prey differ from good hiding sites from predators that use odor to locate prey. We compared characteristics of control sites to sites used for loafing by sharp-tailed grouse (Tympanuchus phasianellus) to determine whether selection of loafing sites was more influenced by the need to hide from visual or olfactory predators. Sites used for loafing were similar to control sites in characteristics that would help hide a grouse from visual predators (i.e., visual obstruction, lateral visibility, visual obstruction, cover ht, and ...