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Jibin Zhang

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Full-Text Articles in Life Sciences

Rna-Seq Analysis Reveals Distinct Splenic Response Of Two Chickens Lines To Newcastle Disease Virus, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Huaijun Zhou, Susan J. Lamont May 2016

Rna-Seq Analysis Reveals Distinct Splenic Response Of Two Chickens Lines To Newcastle Disease Virus, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Huaijun Zhou, Susan J. Lamont

Jibin Zhang

Newcastle disease virus (NDV) is an infectious virus in domestic chickens and is endemic in many countries. It has caused huge economic losses worldwide, especially in developing countries where the chickens and eggs are a primary source of economic income and family nutrition for the rural poor. Due to continuous evolution of NDV and unreliable vaccine production and distribution in developing countries, vaccine cannot prevent recurrent outbreaks of Newcastle disease. Therefore, breeding for NDV resistant chickens is a sustainable approach for alleviating rural poverty and food insecurity.
To identify critical genes regulating NDV resistance, an RNA-seq approach was undertaken with ...