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Medical Sciences

2016

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Full-Text Articles in Life Sciences

Prenatal Methamphetamine Differentially Alters Myocardial Sensitivity To Ischemic Injury In Male And Female Adult Rats, Boyd R. Rorabaugh, Sarah L. Seeley, Albert D. Bui, Lisanne Sprague, Manoranjan S. D’Souza Feb 2016

Prenatal Methamphetamine Differentially Alters Myocardial Sensitivity To Ischemic Injury In Male And Female Adult Rats, Boyd R. Rorabaugh, Sarah L. Seeley, Albert D. Bui, Lisanne Sprague, Manoranjan S. D’Souza

Pharmacy Faculty Scholarship

Methamphetamine is one of the most common illicit drugs abused during pregnancy. The neurological effects of prenatal methamphetamine are well known. However, few studies have investigated the potential effects of prenatal methamphetamine on adult cardiovascular function. Previous work demonstrated that prenatal cocaine exposure increases sensitivity of the adult heart to ischemic injury. Methamphetamine and cocaine have different mechanisms of action, but both drugs exert their effects by increasing dopaminergic and adrenergic receptor stimulation. Thus the goal of this study was to determine whether prenatal methamphetamine also worsens ischemic injury in the adult heart. Pregnant rats were injected with methamphetamine (5 ...