Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Other

Medical Sciences

Ohio Northern University

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Repeated Exposure To Methamphetamine Induces Sex-Dependent Hypersensitivity To Ischemic Injury In The Adult Rat Heart, Boyd R. Rorabaugh, Sarah L. Seeley, Thorne S. Stoops, Manoranjan S. D’Souza Jun 2017

Repeated Exposure To Methamphetamine Induces Sex-Dependent Hypersensitivity To Ischemic Injury In The Adult Rat Heart, Boyd R. Rorabaugh, Sarah L. Seeley, Thorne S. Stoops, Manoranjan S. D’Souza

Pharmacy Faculty Scholarship

BACKGROUND: We previously reported that adult female, but not male rats that were prenatally exposed to methamphetamine exhibit myocardial hypersensitivity to ischemic injury. However, it is unknown whether hypersensitivity to ischemic injury develops when rats are exposed to methamphetamine during adulthood. The goal of this study was to determine whether methamphetamine exposure during adulthood sensitizes the heart to ischemic injury. METHODS: Adult male and female rats received daily injections of methamphetamine (5 mg/kg) or saline for 10 days. Their hearts were isolated on day 11 and subjected to a 20 min ischemic insult on a Langendorff isolated heart apparatus ...


Prenatal Methamphetamine Differentially Alters Myocardial Sensitivity To Ischemic Injury In Male And Female Adult Rats, Boyd R. Rorabaugh, Sarah L. Seeley, Albert D. Bui, Lisanne Sprague, Manoranjan S. D’Souza Feb 2016

Prenatal Methamphetamine Differentially Alters Myocardial Sensitivity To Ischemic Injury In Male And Female Adult Rats, Boyd R. Rorabaugh, Sarah L. Seeley, Albert D. Bui, Lisanne Sprague, Manoranjan S. D’Souza

Pharmacy Faculty Scholarship

Methamphetamine is one of the most common illicit drugs abused during pregnancy. The neurological effects of prenatal methamphetamine are well known. However, few studies have investigated the potential effects of prenatal methamphetamine on adult cardiovascular function. Previous work demonstrated that prenatal cocaine exposure increases sensitivity of the adult heart to ischemic injury. Methamphetamine and cocaine have different mechanisms of action, but both drugs exert their effects by increasing dopaminergic and adrenergic receptor stimulation. Thus the goal of this study was to determine whether prenatal methamphetamine also worsens ischemic injury in the adult heart. Pregnant rats were injected with methamphetamine (5 ...