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Full-Text Articles in Life Sciences

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington Dec 2019

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Ulnar Collateral Ligament Reconstruction (UCLR) is a surgical procedure on one of the main ligaments that provides normal stability for the elbow joint against excessive valgus stress. Damage to this ligament is common in athletes performing overhead throwing activities, primarily baseball players, due to excessive valgus stress during the throwing motion. The most common form of treatment for this type of injury is reconstructive surgery of the ligament, especially if athletes wish to return to sport participation. This type of surgery is extremely invasive and requires extensive post-operative rehabilitation in order to facilitate return to play. To date, many ...


Oscillation In Mathematical Epidemiology, Meredith Greer Oct 2019

Oscillation In Mathematical Epidemiology, Meredith Greer

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Hexavalent Chromium-Induced Cytotoxicity And Mutagenicity: A Study Of Protection By Ascorbic Acid And Epigallocatechin Gallate, Timothy P. Mayotte Jul 2019

Hexavalent Chromium-Induced Cytotoxicity And Mutagenicity: A Study Of Protection By Ascorbic Acid And Epigallocatechin Gallate, Timothy P. Mayotte

Honors Program Projects

Hexavalent chromium, or Cr(VI), is a potent oxidizer and known carcinogen, that is found at varying levels in the water sources of more than 200 million Americans. However, the exact mechanism of carcinogenicity remains unknown, and though the government currently regulates total chromium levels, they have yet to determine a permissible exposure limit for Cr(VI). Moreover, there is currently no preventative treatment for Cr(VI). Because of Cr(VI)’s strong oxidative power, we hypothesized that it causes DNA mutation and cell death via oxidation and that antioxidants could prevent this from occurring. To test this, we first ...


Quantification Of Site Layout And Filter Characteristics On Primary Filter Airflow Reduction On Commercial Swine Sites In Iowa, Benjamin Smith, Steven Hoff, Jay Harmon, Daniel Andersen, Jeffrey Zimmerman, John Stinn Jun 2019

Quantification Of Site Layout And Filter Characteristics On Primary Filter Airflow Reduction On Commercial Swine Sites In Iowa, Benjamin Smith, Steven Hoff, Jay Harmon, Daniel Andersen, Jeffrey Zimmerman, John Stinn

Jay D. Harmon

Fresh air intake filtration is used on commercial swine breeding-gestation-farrowing farms to reduce the frequency of airborne infectious agents. For swine producers, porcine reproductive and respiratory syndrome virus (PRRSV), influenza A virus and Mycoplasma hyopneumoniae are considered the most economically challenging airborne pathogens. Reduced frequency of disease outbreaks has been attributed to retrofitting existing systems with filtration. Economic analysis of operating costs includes energy use, maintenance and replacement of filters. Filter replacement, the largest operational cost, is dependent on filter lifespan. However, limited data is available on filter lifespan and the rate of airflow reduction during the high dust-loading periods ...


Quantification Of Site Layout And Filter Characteristics On Primary Filter Airflow Reduction On Commercial Swine Sites In Iowa, Benjamin Smith, Steven Hoff, Jay Harmon, Daniel Andersen, Jeffrey Zimmerman, John Stinn Jun 2019

Quantification Of Site Layout And Filter Characteristics On Primary Filter Airflow Reduction On Commercial Swine Sites In Iowa, Benjamin Smith, Steven Hoff, Jay Harmon, Daniel Andersen, Jeffrey Zimmerman, John Stinn

Daniel S. Andersen

Fresh air intake filtration is used on commercial swine breeding-gestation-farrowing farms to reduce the frequency of airborne infectious agents. For swine producers, porcine reproductive and respiratory syndrome virus (PRRSV), influenza A virus and Mycoplasma hyopneumoniae are considered the most economically challenging airborne pathogens. Reduced frequency of disease outbreaks has been attributed to retrofitting existing systems with filtration. Economic analysis of operating costs includes energy use, maintenance and replacement of filters. Filter replacement, the largest operational cost, is dependent on filter lifespan. However, limited data is available on filter lifespan and the rate of airflow reduction during the high dust-loading periods ...


Using Educational Board Games Adjunct To Traditional Lectures For Pharmacy Students In Learning Infectious Disease, Sirena Hu, Haley Ethredge, Drew Cates, Essie Samuel Jun 2019

Using Educational Board Games Adjunct To Traditional Lectures For Pharmacy Students In Learning Infectious Disease, Sirena Hu, Haley Ethredge, Drew Cates, Essie Samuel

Drew Cates

To determine if the utilization of modified games, such as ID-Candyland and ID-Taboo, are effective methods to reinforce student knowledge gained in traditional infectious diseases (ID) lectures. When confronted with various challenges of learning ID and the associated pharmacotherapy, pharmacy students often have difficulty applying knowledge learned within the traditional lecture setting to clinical practice and real-life situations involving patients. In addition to lectures and reading assignments, the utilization of educational games can extend learning opportunities, reinforce current understanding and promote a fun and competitive environment. Studies have shown that games are a powerful teaching strategy to develop creative learning ...


The $94 Billion Problem: Application Of Safe Acid Technology (Sat) To Combat Biofilm Infections, Katherine Mulquin, Benjamin Lam, Christopher Capicotto, Olivia Questore Jun 2019

The $94 Billion Problem: Application Of Safe Acid Technology (Sat) To Combat Biofilm Infections, Katherine Mulquin, Benjamin Lam, Christopher Capicotto, Olivia Questore

Benjamin Lam

Purpose: Biofilm infections present a major public health threat. In the U.S. alone, biofilm infections are implicated in up to 550,000 yearly fatalities with an estimated annual cost of $94 billion. Biofilm infections are difficult to treat, as biofilm-secreting bacteria are highly resistant to host immune responses. We hypothesize that Safe Acid Technology (SAT), a unique acid formulation, may reduce the risk of biofilm infections while maximizing patient safety.

Methods: SAT anti-biofilm testing was administered by the Montana State University Center for BioFilm Engineering using a single species (Pseudomonas aeruginosa) biofilm grown in the CDC reactor according to ...


Regulation Of The Drosophila Imd Pathway By Signaling Amyloids, Anni Kleino, Neal S. Silverman Jun 2019

Regulation Of The Drosophila Imd Pathway By Signaling Amyloids, Anni Kleino, Neal S. Silverman

Neal Silverman

Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-kappaB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.


Family Legacy Of Diabetes-Related Behaviors: An Exploration Of The Experiences Of African American Parents And Adult Children, Brianna Routh, Tera R. Hurt, Donna M. Winham, Lorraine Lanningham-Foster Jun 2019

Family Legacy Of Diabetes-Related Behaviors: An Exploration Of The Experiences Of African American Parents And Adult Children, Brianna Routh, Tera R. Hurt, Donna M. Winham, Lorraine Lanningham-Foster

Donna Winham

African Americans are at higher risk of developing type 2 diabetes mellitus (T2DM), and this risk may be influenced by familial experiences and cultural norms throughout the life course. This led us to conduct this study of 20 African American families with strong histories of T2DM to explore familial complexities that prevent or help manage diabetic symptoms. Experiences were analyzed inductively through individual family profiles created using content-analytic summaries. When profiles were further analyzed for emerging and theoretically informed data patterns, two themes emerged: (a) family interactions characterized by T2DM-related actions and communication patterns, and (b) intergenerational patterns of openness ...


Family Legacy Of Diabetes-Related Behaviors: An Exploration Of The Experiences Of African American Parents And Adult Children, Brianna Routh, Tera R. Hurt, Donna M. Winham, Lorraine Lanningham-Foster Jun 2019

Family Legacy Of Diabetes-Related Behaviors: An Exploration Of The Experiences Of African American Parents And Adult Children, Brianna Routh, Tera R. Hurt, Donna M. Winham, Lorraine Lanningham-Foster

Tera R. (Hurt) Jordan

African Americans are at higher risk of developing type 2 diabetes mellitus (T2DM), and this risk may be influenced by familial experiences and cultural norms throughout the life course. This led us to conduct this study of 20 African American families with strong histories of T2DM to explore familial complexities that prevent or help manage diabetic symptoms. Experiences were analyzed inductively through individual family profiles created using content-analytic summaries. When profiles were further analyzed for emerging and theoretically informed data patterns, two themes emerged: (a) family interactions characterized by T2DM-related actions and communication patterns, and (b) intergenerational patterns of openness ...


A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine, Allan Uribe Jun 2019

A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine, Allan Uribe

Dissertations and Theses

Cardiovascular disease is the leading cause of death worldwide. Coronary Artery Disease (CAD) accounts for the majority of those deaths. Observational studies have identified risk factors that have been helpful in lowering the death rate, including hypertension, high cholesterol, diabetes, smoking, physical inactivity and poor diet. The effects of these risk factors on CAD remain unclear. To clarify the effect of three amino acids, alanine, glutamine, and glycine on CAD I applied a two sample Mendelian randomization analysis to extensively genotyped observational data. In a sample with up to 184,000 individuals and approximately 60,000 controls, SNPs that reached ...


Quantification Of Site Layout And Filter Characteristics On Primary Filter Airflow Reduction On Commercial Swine Sites In Iowa, Benjamin Smith, Steven Hoff, Jay Harmon, Daniel Andersen, Jeffrey Zimmerman, John Stinn Jun 2019

Quantification Of Site Layout And Filter Characteristics On Primary Filter Airflow Reduction On Commercial Swine Sites In Iowa, Benjamin Smith, Steven Hoff, Jay Harmon, Daniel Andersen, Jeffrey Zimmerman, John Stinn

Agricultural and Biosystems Engineering Publications

Fresh air intake filtration is used on commercial swine breeding-gestation-farrowing farms to reduce the frequency of airborne infectious agents. For swine producers, porcine reproductive and respiratory syndrome virus (PRRSV), influenza A virus and Mycoplasma hyopneumoniae are considered the most economically challenging airborne pathogens. Reduced frequency of disease outbreaks has been attributed to retrofitting existing systems with filtration. Economic analysis of operating costs includes energy use, maintenance and replacement of filters. Filter replacement, the largest operational cost, is dependent on filter lifespan. However, limited data is available on filter lifespan and the rate of airflow reduction during the high dust-loading periods ...


Undergraduate Research Award.Pdf, Saumya Jain Jun 2019

Undergraduate Research Award.Pdf, Saumya Jain

Saumya Jain

Glycoproteins are important compounds that are studied for their ability to regulate cellular behavior in several important biological processes. The function of these glycosylated proteins is still vastly unknown due to obstacles faced with synthesis of their highly specified structure. Prior literature has been unable to isolate these compounds in a stable form which would reveal information about their structure-to-function relationship. Therein we have developed a novel synthesis that furnishes a high yield of a hydrolytically stable, glycosylated asparagine residue that is suitable for solid-phase peptide synthesis of N-linked glycoproteins.


Reflective Statement.Pdf, Lydia Griggs, Saumya Jain, Paul Goo Jun 2019

Reflective Statement.Pdf, Lydia Griggs, Saumya Jain, Paul Goo

Saumya Jain

No abstract provided.


Glycine Supplementation Extends Lifespan Of Male And Female Mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, Randy Strong Jun 2019

Glycine Supplementation Extends Lifespan Of Male And Female Mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, Randy Strong

Faculty Research 2019

Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%-6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycine-supplemented females were lighter than controls, but there was no effect on weight in males. End-of-life necropsies suggested that glycine-treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine-supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI-1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late-life diseases.


Effects Of Igf-1 Isoforms On Muscle Growth And Sarcopenia., Francesca Ascenzi, Laura Barberi, Gabriella Dobrowolny, Aline Villa Nova Bacurau, Carmine Nicoletti, Emanuele Rizzuto, Nadia Rosenthal, Bianca Maria Scicchitano, Antonio Musarò Jun 2019

Effects Of Igf-1 Isoforms On Muscle Growth And Sarcopenia., Francesca Ascenzi, Laura Barberi, Gabriella Dobrowolny, Aline Villa Nova Bacurau, Carmine Nicoletti, Emanuele Rizzuto, Nadia Rosenthal, Bianca Maria Scicchitano, Antonio Musarò

Faculty Research 2019

The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia, is the result of many factors including an imbalance between protein synthesis and degradation, changes in metabolic/hormonal status, and in circulating levels of inflammatory mediators. Thus, factors that increase muscle mass and promote anabolic pathways might be of therapeutic benefit to counteract sarcopenia. Among these, the insulin-like growth factor-1 (IGF-1) has been implicated in many anabolic pathways in skeletal muscle. IGF-1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF-1Ea and IGF-1Eb ...


Crystal Structure Of Zymonic Acid And A Redetermination Of Its Precursor, Pyruvic Acid, Dominik Heger, Alexis J. Eugene, Sean R. Parkin, Marcelo I. Guzman Jun 2019

Crystal Structure Of Zymonic Acid And A Redetermination Of Its Precursor, Pyruvic Acid, Dominik Heger, Alexis J. Eugene, Sean R. Parkin, Marcelo I. Guzman

Chemistry Faculty Publications

The structure of zymonic acid (systematic name: 4-hy­droxy-2-methyl-5-oxo-2,5-di­hydro­furan-2-carb­oxy­lic acid), C6H6O5, which had previously eluded crystallographic determination, is presented here for the first time. It forms by intra­molecular condensation of parapyruvic acid, which is the product of aldol condensation of pyruvic acid. A redetermination of the crystal structure of pyruvic acid (systematic name: 2-oxo­propanoic acid), C3H4O3, at low temperature (90 K) and with increased precision, is also presented [for the previous structure, see: Harata et al. (1977). Acta Cryst. B33, 210–212 ...


Food Insecurity Among South Asian Immigrant Communities In The Inland Empire Of Southern California, Farhan Danish Jun 2019

Food Insecurity Among South Asian Immigrant Communities In The Inland Empire Of Southern California, Farhan Danish

Electronic Theses, Projects, and Dissertations

Background: Food insecurity amongst South Asian Americans is a major public health issue. The South Asian American (SAA) community is the third largest Asian community in the United States. Despite this fact, very few specific studies have been conducted to investigate the food needs and barriers that exist within the SAA community so as to successfully help them improve dietary habits.

Methods: This study utilized a mixed methods convergent parallel design, where both qualitative and quantitative methods were conducted and analyzed separately and compared and contrasted at the end.

Results: The results of this study demonstrate that ethnic grocery stores ...


Health Disparities Among South Asians: Is Food Insecurity The Missing Link?, Valentina Chawdhury Jun 2019

Health Disparities Among South Asians: Is Food Insecurity The Missing Link?, Valentina Chawdhury

Electronic Theses, Projects, and Dissertations

Objective: Food insecurity among South Asians in the US is a public health issue. Food insecure adults face a plethora of adverse outcomes and research shows that individuals with ancestral origins from South Asia have a higher susceptibility rate for cardiovascular disease after migrating to urban environments. As such, the goal of this study was to research possible barriers South Asians face when creating cultural dishes in the US.

Methods: This was a convergent parallel mixed-methods analysis to understand how South Asians feel about food insecurity. Pricing and availability of cultural food items were obtained from South Asian and Western ...


Systematic Review Of Cognitive Behavior Therapy In Women Living With Hiv Infection, Joseph S. Cervia Md May 2019

Systematic Review Of Cognitive Behavior Therapy In Women Living With Hiv Infection, Joseph S. Cervia Md

Joseph Cervia

No abstract provided.


Knee Range Of Motion: Reliability And Agreement Of 3 Measurement Methods, Paul G. Peters, Michael A. Herbenick, Philip A. Anloague, Ronald J. Markert, L. Joseph Rubino May 2019

Knee Range Of Motion: Reliability And Agreement Of 3 Measurement Methods, Paul G. Peters, Michael A. Herbenick, Philip A. Anloague, Ronald J. Markert, L. Joseph Rubino

Ronald Markert

We conducted a study to compare 3 methods of measuring knee range of motion: visual estimation by physicians, hand goniometry by physical therapists, and radiographic goniometry. We hypothesized that reliability would be high within and across all techniques. We found intrarater and interrater reliability to be satisfactory for visual estimation, hand goniometry, and radiographic goniometry. Interrater reliability across methods did not agree satisfactorily. Between-methods differences in estimating knee range of motion may result from variations in technique among physicians and physical therapists.


An Overview Of American Ginseng Through The Lens Of Healing, Conservation And Trade, Margaret Wulfsberg May 2019

An Overview Of American Ginseng Through The Lens Of Healing, Conservation And Trade, Margaret Wulfsberg

Lawrence University Honors Projects

American ginseng (Panax quinquefolius) is an herbaceous plant found in the eastern United States and Canada. Due to the high demand for ginseng roots on the Chinese market, it has been harvested at unsustainable rates. If this continues, overharvest along with other environmental factors will lead it to become extinct in the wild. American ginseng became popular due to its similarities with Asian ginseng, (Panax ginseng), a related plant that has been used in Chinese medicine for hundreds of years. Since there is so little Asian ginseng left in the wild, American ginseng now helps satisfy the demand for wild ...


Omg! The Best Keto Viante Netherland Ever!S | Reduce Body & Belly Fat, Keto Healthys May 2019

Omg! The Best Keto Viante Netherland Ever!S | Reduce Body & Belly Fat, Keto Healthys

keto healthys

Keto Viante NetherlandThis is the astounding recipe which will go to upgrade the ketosis condition of the body. The body needs ketosis to get more fit. This is made for guys and females. This is additionally made for children. So be upbeat as though your children are substantial due to the awful dietary patterns or it very well may be a direct result of the qualities impacts then you should offer this to your tyke. This is important to keep up the dose of your pills. Individuals are becoming weary of spending immense measure of cash behind some unimportant ...


Spirituality And The Infant Brain: Implications For Attachment Theory And Therapeutic Process Across The Life Span, Caitlin Eliasson May 2019

Spirituality And The Infant Brain: Implications For Attachment Theory And Therapeutic Process Across The Life Span, Caitlin Eliasson

Consensus

No abstract provided.


One Reference Genome Is Not Enough., Xiaofei Yang, Wan-Ping Lee, Kai Ye, Charles Lee May 2019

One Reference Genome Is Not Enough., Xiaofei Yang, Wan-Ping Lee, Kai Ye, Charles Lee

Faculty Research 2019

A recent study on human structural variation indicates insufficiencies and errors in the human reference genome, GRCh38, and argues for the construction of a human pan-genome.


Plant Essential Oils Synergize Various Pyrethroid Insecticides And Antagonize Malathion In Aedes Aegypti, E. J. Norris, A. D. Gross, L. C. Bartholomay, J. R. Coats May 2019

Plant Essential Oils Synergize Various Pyrethroid Insecticides And Antagonize Malathion In Aedes Aegypti, E. J. Norris, A. D. Gross, L. C. Bartholomay, J. R. Coats

Joel R. Coats

Pyrethroid resistance is a significant threat to agricultural, urban and public health pest control activities. Because economic incentives for the production of novel active ingredients for the control of public health pests are lacking, this field is particularly affected by the potential failure of pyrethroid‐based insecticides brought about by increasing pyrethroid resistance. As a result, innovative approaches are desperately needed to overcome insecticide resistance, particularly in mosquitoes that transmit deadly and debilitating pathogens. Numerous studies have demonstrated the potential of plant essential oils to enhance the efficacy of pyrethroids. The toxicity of pyrethroids combined with plant oils is significantly ...


Composition And Predictive Functional Analysis Of Bacterial Communities Inhabiting Chinese Cordyceps Insight Into Conserved Core Microbiome., Fei Xia, Xin Zhou, Yan Liu, Yuling Li, Xiaohui Bai, Xuanwei Zhou May 2019

Composition And Predictive Functional Analysis Of Bacterial Communities Inhabiting Chinese Cordyceps Insight Into Conserved Core Microbiome., Fei Xia, Xin Zhou, Yan Liu, Yuling Li, Xiaohui Bai, Xuanwei Zhou

Faculty Research 2019

BACKGROUND: Over the past few decades, most attention to Chinese Cordyceps-associated endogenous microorganism was focused on the fungal community that creates critical bioactive components. Bacterial community associated with Chinese Cordyceps has been previously described; however, most studies were only presenting direct comparisons in the Chinese Cordyceps and its microenvironments. In the current study, our objectives were to reveal the bacterial community structure composition and predict their function.

RESULTS: We collected samples of Chinese Cordyceps from five sites located in the Qinghai-Tibet Plateau and used a high throughput sequencing method to compare Chinese Cordyceps-associated bacterial community composition and diversity quantitatively across ...


Character Development In Youth Sports, Nicholas Stenzel May 2019

Character Development In Youth Sports, Nicholas Stenzel

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis project was to review the literature on factors that influence character development of youth sport athletes. An extensive review of literature was conducted in order to analysis and character development and the leading factors to its development among youth athletes. There are many positives that come along with youth sport participation, and participating in sports has been known to help in the development of character and life skills. This synthesis will review the literature on participation of youth athletes in sports and the role coaches, parents and teachers play in the impact of character development.


The Effects Socioeconomic Status, Nutrition, And Physical Activity Have On The Youth, Felix Morales May 2019

The Effects Socioeconomic Status, Nutrition, And Physical Activity Have On The Youth, Felix Morales

Kinesiology, Sport Studies, and Physical Education Synthesis Projects

The purpose of this synthesis was to identify the effects socioeconomic status (SES), Physical activity (PA), and nutrition have on the youth. Despite the known benefits of being physically active and eating healthier food options, fewer than half of the U.S. school aged children meet national recommendations of 60 minutes of daily PA and one third fewer meet recommendations for fruit and vegetable consumption (Donnelly & Springer, 2015). This synthesis examined literature and articles which primarily focused on how low SES youth are effected by their communities differently than youth who reside in high SES communities. The following four questions ...


Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G Denardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M Mcgee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, Francesco M Marincola May 2019

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G Denardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M Mcgee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, Francesco M Marincola

Faculty Research 2019

Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes ...