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Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Kinesiology

2014

Selected Works

Mark S. Miller

Articles 1 - 1 of 1

Full-Text Articles in Life Sciences

Skeletal Muscle Myofilament Adaptations To Aging, Disease And Disuse And Their Effects On Whole Muscle Performance In Older Adult Humans, Mark S. Miller, Damien M. Callahan, Michael J. Toth Dec 2013

Skeletal Muscle Myofilament Adaptations To Aging, Disease And Disuse And Their Effects On Whole Muscle Performance In Older Adult Humans, Mark S. Miller, Damien M. Callahan, Michael J. Toth

Mark S. Miller

Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle contractile function depends on a variety of factors, but force, contractile velocity and power generating capacity ultimately derive from the summed contribution of single muscle fibers. The contractile performance of these fibers are, in turn, dependent upon the isoform and function of myofilament proteins they express, with myosin protein expression and its mechanical and kinetic characteristics playing a predominant role. Alterations in myofilament protein biology, therefore, may contribute to the development of functional limitations and disability in these conditions. Recent studies suggest that these conditions are associated ...