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Immunology and Infectious Disease

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Full-Text Articles in Life Sciences

Size Selective Parasitism Of Rainbow Trout (Oncorhynchus Mykiss) By Chestnut Lampreys (Ichthyomyzon Castaneus) In An Artificial Setting, Jeremiah M. Salinger, Ronald L. Johnson May 2020

Size Selective Parasitism Of Rainbow Trout (Oncorhynchus Mykiss) By Chestnut Lampreys (Ichthyomyzon Castaneus) In An Artificial Setting, Jeremiah M. Salinger, Ronald L. Johnson

Southeastern Fishes Council Proceedings

Paradigms of optimal resource utilization by animals, both classical and more recent, were not originally developed in the context of parasitism. Though this oversight has slowly been reversed, little attention has been paid to optimal resource utilization by parasitic fishes, such as lampreys. Multiple explanations for host size selection by parasitic lampreys may be plausible, but results from previous studies have been inconsistent. We studied host size selection by Chestnut Lampreys (Ichthyomyzon castaneus) parasitizing Rainbow Trout (Oncorhynchus mykiss) in fish hatchery raceways in north central Arkansas during the late winter and early spring of 2013. Parasitized Rainbow Trout were significantly ...


Modeling Vaccination Strategies To Control White-Nose Syndrome In Little Brown Bat Colonies, Eva Cornwell, David Elzinga, Shelby R. Stowe, Alex Capaldi May 2020

Modeling Vaccination Strategies To Control White-Nose Syndrome In Little Brown Bat Colonies, Eva Cornwell, David Elzinga, Shelby R. Stowe, Alex Capaldi

Biology and Medicine Through Mathematics Conference

No abstract provided.


Mathematical Modeling Of The Car T-Cell Therapy, Emek Kose, Elizabeth Zollinger, Samantha Elliott May 2020

Mathematical Modeling Of The Car T-Cell Therapy, Emek Kose, Elizabeth Zollinger, Samantha Elliott

Biology and Medicine Through Mathematics Conference

No abstract provided.


In Silico Mouse Model Of Infection And Immunity, Daniel Jonas, Michael Kirby, Alan R. Schenkel May 2020

In Silico Mouse Model Of Infection And Immunity, Daniel Jonas, Michael Kirby, Alan R. Schenkel

Biology and Medicine Through Mathematics Conference

No abstract provided.


The Class Of 2020, Srinivasan Ragothaman May 2020

The Class Of 2020, Srinivasan Ragothaman

Creative Work

The is a poem written in honor of the class of 2020. The coronavirus pandemic has robbed them of many fun activities in their final semester in college. The graduating seniors missed out on so many rites of passage such as march madness, commencement, award banquets, sports, labs, practice, face-to-face classes etc. for the last two months. Seniors are encouraged to have fortitude, practice patience, be grateful and show grit. The class of 2020 will conquer the world in due course. It is hoped that graduates will have imagination, will innovate and transform the world.


The Relationship Between Glucocorticoids And The Humoral Immune Response To Mycoplasma Gallisepticum Challenges In Eastern Bluebirds, Joshua Smith May 2020

The Relationship Between Glucocorticoids And The Humoral Immune Response To Mycoplasma Gallisepticum Challenges In Eastern Bluebirds, Joshua Smith

Honors Theses

Numerous studies have examined relationships between adrenal glucocorticoids and the immune system’s ability to fight disease. The relationship can vary, with glucocorticoids having either stimulatory or inhibitory effects. The pathogenic bacterium Mycoplasma gallisepticum (MG) elicits an adaptive immune response in birds, in which B cells produce MG-specific antibodies to fight the infection and prevent reoccurrence. Previous research found that Eastern Bluebirds that produce the most antibodies in response to MG infection also have the highest glucocorticoid levels. This finding led to the current study investigating whether corticosterone, the primary glucocorticoid in birds, stimulates production of antibodies in response to ...


The Society For Immunotherapy Of Cancer Perspective On Regulation Of Interleukin-6 Signaling In Covid-19-Related Systemic Inflammatory Response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, Paolo Antonio Ascierto May 2020

The Society For Immunotherapy Of Cancer Perspective On Regulation Of Interleukin-6 Signaling In Covid-19-Related Systemic Inflammatory Response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, Paolo Antonio Ascierto

Articles, Abstracts, and Reports

The pandemic caused by the novel coronavirus SARS-CoV-2 has placed an unprecedented burden on healthcare systems around the world. In patients who experience severe disease, acute respiratory distress is often accompanied by a pathological immune reaction, sometimes referred to as ‘cytokine storm’. One hallmark feature of the profound inflammatory state seen in patients with COVID-19 who succumb to pneumonia and hypoxia is marked elevation of serum cytokines, especially interferon gamma, tumor necrosis factor alpha, interleukin 17 (IL-17), interleukin 8 (IL-8) and interleukin 6 (IL-6). Initial experience from the outbreaks in Italy, China and the USA has anecdotally demonstrated improved outcomes ...


The Influence Of Climate Change On Disease And Public Health, Natalie Petruzelli May 2020

The Influence Of Climate Change On Disease And Public Health, Natalie Petruzelli

The Review: A Journal of Undergraduate Student Research

This paper attempts to analyze the growing influence of climate change on the spread and development of diseases, as well as how this continues to affect public health and medical administrations around the world. The prevalence of airborne, waterborne, and vector-borne diseases have been found to be exacerbated as a result of climate change. In addition to this, the paper addresses the reemergence of eliminated diseases and ancient pathogens due to changing temperatures and weather patterns. Finally, the effect of these different conditions on national and international public health organizations and policies is analyzed, including projections on what can be ...


Investigating The Interactions Between Individual Calmodulin And Hiv-1 Protein Domains, Riley K. Kendall, Jerry Larue May 2020

Investigating The Interactions Between Individual Calmodulin And Hiv-1 Protein Domains, Riley K. Kendall, Jerry Larue

Student Scholar Symposium Abstracts and Posters

The World Health Organization found that 37.9 million people were living with HIV by the end of 2018. HIV is a virus that weakens the immune system through viral replication and the destruction of CD4+ T-cells, which are white blood cells that detect infection and make antibodies. A cure for HIV has not yet been discovered. HIV-1 contains a Gag polyprotein which regulates the stages of viral replication. Previous studies suggest that the myristoyl group of a matrix protein peptide found on the Gag polyprotein, MA, forms a complex with a calcium-binding, multifunctional regulatory protein called Calmodulin (CaM). CaM ...


Use Of Diatomaceous Earth And Copper Oxide Wire Particles To Control Gastrointestinal Nematodes In Lambs, Olivia Jones May 2020

Use Of Diatomaceous Earth And Copper Oxide Wire Particles To Control Gastrointestinal Nematodes In Lambs, Olivia Jones

Animal Science Undergraduate Honors Theses

Abstract

Anthelmintic resistance (AR) urges alternatives to control gastrointestinal nematodes (GIN). Copper oxide wire particles (COWP) are more efficacious when used with other dewormers and little is known on efficacy of diatomaceous earth (DE) to control gastrointestinal parasites. The objective was to examine the effects of DE and COWP on GIN control. Katahdin lambs (n = 32; ~150 d of age; 25.0 ± 1.8 kg) were randomly assigned to receive: 1) DE fed at an estimated 2% dry matter intake (with the assumption of moderate consumption of bermudagrass forage and provided supplement), 2) 1g COWP, 3) both 2% DE and ...


Effect Of Zelnate Administered As A Metaphylactic Upon Initial Processing Of High-Risk, Newly Received Beef Calves On Performance And Morbidity, Brady Martin May 2020

Effect Of Zelnate Administered As A Metaphylactic Upon Initial Processing Of High-Risk, Newly Received Beef Calves On Performance And Morbidity, Brady Martin

Animal Science Undergraduate Honors Theses

Bovine Respiratory Disease (BRD) is the most prominent and costly ailment in the stocker cattle industry today, and its prevalence has not been diminished in the last thirty years. Therefore, the objective of this study was to investigate the effects of Zelnate, a DNA immunostimulant, administered upon arrival to calves (n = 261; BW 253 ± 4.0 kg), on morbidity/mortality, performance and producer costs. Crossbred male beef calves were acquired and transported to the University of Arkansas stocker unit for a 42-d backgrounding period. Calves were allocated into treatment groups: 1) Zelnate, DNA immunostimulant administered or 2) Control, in which ...


Mathematic Modeling Of Covid-19 In The United States, Yuanji Tang, Shixia Wang Apr 2020

Mathematic Modeling Of Covid-19 In The United States, Yuanji Tang, Shixia Wang

Coronavirus COVID-19 Publications by UMMS Authors

Since the early reports of COVID-19 cases in China in late January 2020 (1-2), the worst pandemic in 100 years has spread to the entire globe with approximately 2.4 million diagnosed cases and over 165,000 deaths up to April 20, 2020.

While scientists from various public and private groups use math and computer to simulate the course of this pandemic to try to predict how this outbreak might evolve (3), most of such analyses are either quite complicated or not publicly available.

Here a simple mathematic modeling approach is taken to track the outbreaks of COVID-19 in the ...


Effects Of Individual Orsay Virus Proteins On The Intracellular Pathogen Response Of C. Elegans, Barbara Chen, Jessica N. Sowa Apr 2020

Effects Of Individual Orsay Virus Proteins On The Intracellular Pathogen Response Of C. Elegans, Barbara Chen, Jessica N. Sowa

Biology Student Work

In order to cause infection, pathogens must avoid destruction by the host immune system. However, how pathogens evolved to evade host immunity is not fully understood. Mammals have two systems of immunity, innate and adaptive, which are regulated by complex interactions between the two systems. In order to study innate immunity exclusively, the roundworm C. elegans is a useful invertebrate model because it lacks adaptive immunity and the complexities that arise from interactions between the two types of immunity. The goal of this project is to investigate whether the individual expression of the Orsay virus capsid and delta-fusion proteins can ...


Identifying Novel Triggers Of The Intracellular Pathogen Response (Ipr) In C. Elegans, Catherine T. Byrnes, Jessica N. Sowa Apr 2020

Identifying Novel Triggers Of The Intracellular Pathogen Response (Ipr) In C. Elegans, Catherine T. Byrnes, Jessica N. Sowa

Biology Student Work

The intracellular pathogen response (IPR) is a cell signaling pathway found in C. elegans that is triggered when pathogenic microorganisms invade, and immune responses attempt to eliminate the threat. Due to the relative simplicity of C. elegans, they are an excellent model organism to analyze the cell signaling pathways triggered by various pathogens. They lack the complex immune systems of larger organisms, making it easier to study the involved cell signaling pathways. Past studies have shown that the IPR can also be triggered via intestinal wounding. Heat stress, viral infection, and proteasome stress are all known triggers of the IPR ...


Sars-Cov-2 Receptor Ace2 Is An Interferon-Stimulated Gene In Human Airway Epithelial Cells And Is Detected In Specific Cell Subsets Across Tissues, Carly G. K. Ziegler, Yuming Cao, Zhiru Guo, Jennifer P. Wang, Robert W. Finberg, Manuel Garber, Alex K. Shalek, Jose Ordovas-Montanes, Hca Lung Biological Network Apr 2020

Sars-Cov-2 Receptor Ace2 Is An Interferon-Stimulated Gene In Human Airway Epithelial Cells And Is Detected In Specific Cell Subsets Across Tissues, Carly G. K. Ziegler, Yuming Cao, Zhiru Guo, Jennifer P. Wang, Robert W. Finberg, Manuel Garber, Alex K. Shalek, Jose Ordovas-Montanes, Hca Lung Biological Network

Coronavirus COVID-19 Publications by UMMS Authors

There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. We identify ACE2 and TMPRSS2 co-expressing cells within lung ...


The Covid-19 Pandemic: A Comprehensive Review Of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, And Control, Yosra A. Helmy, Mohamed Fawzy, Ahmed Elaswad, Ahmed Sobieh, Scott P. Kenney, Awad A. Shehata Apr 2020

The Covid-19 Pandemic: A Comprehensive Review Of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, And Control, Yosra A. Helmy, Mohamed Fawzy, Ahmed Elaswad, Ahmed Sobieh, Scott P. Kenney, Awad A. Shehata

Coronavirus COVID-19 Publications by UMMS Authors

A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market. The causative agent of the outbreak was identified by the WHO as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), producing the disease named coronavirus disease-2019 (COVID-19). The virus is closely related (96.3%) to bat coronavirus RaTG13, based on phylogenetic analysis. Human-to-human transmission has been confirmed even from asymptomatic carriers. The virus has spread to at least 200 countries, and more than 1,700,000 confirmed cases and 111,600 deaths have been recorded, with massive global ...


Fact Or Myth: The Flu Can Be Caused By The Flu Vaccine, Arleigh Wood Apr 2020

Fact Or Myth: The Flu Can Be Caused By The Flu Vaccine, Arleigh Wood

Student Showcase for Research and Creative Inquiry

To many, the flu vaccine seems like a threat to an otherwise healthy individual. People often get the flu after receiving the flu shot, which does not promote confidence in the general public. These and other reasonings have created a myth that the flu vaccine can cause the flu. Understanding how the vaccination is created and how it interacts with the immune system helps to realize why the flu vaccine cannot cause the virus. For the vaccine to work, adaptive immunity must be activated by the introduction of the viral particles in a safe manner. An effective immune response from ...


465— Modeling Vaccine Efficacy For Tuberculosis In A Prison Population, Kaitlyn Mundackal Apr 2020

465— Modeling Vaccine Efficacy For Tuberculosis In A Prison Population, Kaitlyn Mundackal

GREAT Day

Tuberculosis is a highly contagious disease and is particularly problematic in confined communities such as prisons. I simulated how Tuberculosis moves through a prison population and tested how much vaccination effort is needed to control its spread. To explore this, I tested adding ever increasing numbers of randomly placed edges in a network and determined the size of the largest component. Afterwards, I removed edges in the model using two different methods, one illustrating if the edges were removed randomly and the other starting with prisoners that had the most connections, to simulate the effect of vaccination. My results show ...


147— The Effect Of A Histone Deacetylase Inhibitor On Pd-L1, Hla-Abc, Hla-E, And Hla-G On Human Breast Cancer Cell Lines, Nikhil Reddy, Alec Toufexis Apr 2020

147— The Effect Of A Histone Deacetylase Inhibitor On Pd-L1, Hla-Abc, Hla-E, And Hla-G On Human Breast Cancer Cell Lines, Nikhil Reddy, Alec Toufexis

GREAT Day

Increased expression of human leukocyte antigen (HLA) allows tumor cells to be more easily detected by the immune system. In previous research, epigenetic modifiers including the histone deacetylase inhibitor 3 (HDAC3), RGFP966, has been shown to decrease PD-L1 expression. PD-L1 expression inhibits T cell cytotoxicity, and decreasing it can enhance the immune response. We hope to elucidate whether or not HLA-ABC expression similarly decreases upon exposure to the HDAC3 inhibitor which would be detrimental to immune detection. Two breast cancer cell lines that express HLA-ABC are MCF-7 and MDA-MB-231. Our initial results show that HLA-ABC is expressed on the MDA-MB-231 ...


Biol 404- The Effects Of Dioxin-Like Polychlorinated Biphenyls (Pcbs) On The Development Of Myeloid Suppressor Cells, Emma Rogers, Ryan Servis, Talbot Thames, Amorette Barber Apr 2020

Biol 404- The Effects Of Dioxin-Like Polychlorinated Biphenyls (Pcbs) On The Development Of Myeloid Suppressor Cells, Emma Rogers, Ryan Servis, Talbot Thames, Amorette Barber

Student Showcase for Research and Creative Inquiry

Polychlorinated biphenyls (PCBs) are a man-made organic compound consisting of two phenyl rings connected by a single bond, with any number of chlorine molecules occupying positions around the rings. They are most commonly used as a dielectric and coolant fluid in electrical generators and transformers. Manufacture has declined drastically since the 1970s in America due to their exertion of estrogen-mimicking effects in the body, although they continue to persist in harmful concentrations in the environment. PCBs are endocrine-disrupting, and through estrogenic or anti-estrogenic effects have been shown to increase breast cancer risk by changing gene expression in several genes common ...


Biol 404- Effects Of Estrogen-Mimicking Compounds, Progesterone And Estriol, On Myeloid-Derived Suppressor Cell Development, Raquel Perez, Tatyana Green, Haley Bresnahan, Matthew Jones, Amorette Barber Apr 2020

Biol 404- Effects Of Estrogen-Mimicking Compounds, Progesterone And Estriol, On Myeloid-Derived Suppressor Cell Development, Raquel Perez, Tatyana Green, Haley Bresnahan, Matthew Jones, Amorette Barber

Student Showcase for Research and Creative Inquiry

Estrogen is primarily known for being a female sex hormone. It has three major subcategories estrone, estradiol, and estriol. They are known to have a role within regulation of the reproductive system and menopause. Progesterone is also a well-known steroid sex hormone that is usually associated with menstruation. These sex hormones are commonly used in oral contraceptive pills. The purpose of this study is to see if progesterone and estriol will have the same effects that estrogen has on MHC II and B7 expression. With the use of flow cytometry, T cell isolation, T cell proliferation, and ELISAs we are ...


Biol 404- Effects Of Phytoestrogens - Lycopene And Trans-Resveratrol - On The Development Of Myeloid-Derived Suppressor Cells (Mdsc), Kayla Cooksey, Adrianna Doggett, Debbie Pitt, Maya Young, Amorette Barber Apr 2020

Biol 404- Effects Of Phytoestrogens - Lycopene And Trans-Resveratrol - On The Development Of Myeloid-Derived Suppressor Cells (Mdsc), Kayla Cooksey, Adrianna Doggett, Debbie Pitt, Maya Young, Amorette Barber

Student Showcase for Research and Creative Inquiry

Trans-Resveratrol and Lycopene are chemical compounds found in the skin of red grapes and tomatoes respectively. This study investigates the effects of these two phytoestrogens on MDSCs.We hypothesized that these phytoestrogens will bind to estrogen receptors and block estrogenic activity, effectively decreasing the production of MDSCs in murine cells.


Biol 404- Dual Nature Of Phytoestrogens As Both Procancer And Anticancer Agents, Marcia Lanasa, Grace Freeman, Carrie Reaver, Natalie Wood, Amorette Barber Apr 2020

Biol 404- Dual Nature Of Phytoestrogens As Both Procancer And Anticancer Agents, Marcia Lanasa, Grace Freeman, Carrie Reaver, Natalie Wood, Amorette Barber

Student Showcase for Research and Creative Inquiry

Phytoestrogens are plant-derived, xenoestrogenic dietary compounds found in various fruits, vegetables, soy products, teas, grains, beans, and more. There are different classes of phytoestrogens, including flavonoids, isoflavonoids, lignans, and coumestans, all of which can affect estrogen-mediated responses in different ways (Bilal et al, 2014). The aim of this project is to investigate the potential duality of phytoestrogens as both estrogen receptor antagonists in cancer cells, but also as potential activators of myeloid-derived suppressor cells. Understanding the complex role phytoestrogens play in cancer progression will prove valuable in the potential development of novel phytoestrogen-base cancer drug therapies.


Biol 404- Can A Soy Diet Mimic The Effects Of Estrogen?, Kelly Tarmon, Jonah Hottinger, Emily Humphries, Cody Gouyer, Amorette Barber Apr 2020

Biol 404- Can A Soy Diet Mimic The Effects Of Estrogen?, Kelly Tarmon, Jonah Hottinger, Emily Humphries, Cody Gouyer, Amorette Barber

Student Showcase for Research and Creative Inquiry

Phytoestrogens are estrogen-mimicking substances that can be found in many of the vegetables, beans, and grains we consume. One of the main phytoestrogens consumed by millions of people can be found in soybeans and tofu and are called isoflavones. We will be examining the first category of isoflavones, the aglycones. The aglycones are made up of daidzein, genistein, and glycitein which are found in soy products. We will determine the function of aglycones using flow cytometry by comparing the effect of these three compounds, estradiol, and the media given. As aglycones are estrogen mimicking compounds, we believe these three phytoestrogens ...


Broad Host Range Of Sars-Cov-2 Predicted By Comparative And Structural Analysis Of Ace2 In Vertebrates, Joana Damas, Elinor K. Karlsson, Harris A. Lewin Apr 2020

Broad Host Range Of Sars-Cov-2 Predicted By Comparative And Structural Analysis Of Ace2 In Vertebrates, Joana Damas, Elinor K. Karlsson, Harris A. Lewin

University of Massachusetts Medical School Faculty Publications

The novel coronavirus SARS-CoV-2 is the cause of Coronavirus Disease-2019 (COVID-19). The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of 410 vertebrates, including 252 mammals, to study cross-species conservation of ACE2 and its likelihood to function as a SARS-CoV-2 receptor. We designed a five-category ranking score based on the conservation properties of 25 amino acids important for the binding between receptor and virus, classifying all species from very high to very low. Only mammals fell ...


Single-Cell Analysis Of Upper Airway Cells Reveals Host-Viral Dynamics In Influenza Infected Adults, Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick Mcdonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, Manuel Garber Apr 2020

Single-Cell Analysis Of Upper Airway Cells Reveals Host-Viral Dynamics In Influenza Infected Adults, Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick Mcdonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, Manuel Garber

University of Massachusetts Medical School Faculty Publications

Influenza virus infections are major causes of morbidity and mortality. Research using cultured cells, bulk tissue, and animal models cannot fully capture human disease dynamics. Many aspects of virus-host interactions in a natural setting remain unclear, including the specific cell types that are infected and how they and neighboring bystander cells contribute to the overall antiviral response. To address these questions, we performed single-cell RNA sequencing (scRNA-Seq) on cells from freshly collected nasal washes from healthy human donors and donors diagnosed with acute influenza during the 2017-18 season. We describe a previously uncharacterized goblet cell population, specific to infected individuals ...


The Growing Threat Of Agroterrorism And Strategies For Agricultural Defense, Alyssa Forrest Apr 2020

The Growing Threat Of Agroterrorism And Strategies For Agricultural Defense, Alyssa Forrest

Senior Honors Theses

Due to the dynamic nature of human conflict, non-traditional terror tactics have evolved to undermine the socioeconomic stability of targeted societies. Considering the landscape in which terrorists operate, emphasis on more subversive methods of biological terror have become prominent in recent decades. Agroterrorism, or the use of plant pathogens to infect a nation’s cultivated crops, is an emerging topic due to its threat to global food security and economic stability. Although emergency preparedness objectives have been enacted at national, state, and even local levels, preemptive measures can no longer remain the sole responsibility of intelligence and law enforcement agencies ...


Covid-19 Travel Restrictions And The International Health Regulations - Call For An Open Debate On Easing Of Travel Restrictions, Eskild Petersen, Brian Mccloskey, David S. Hui, Richard Kock, Francine Ntoumi, Ziad A. Memish, Nathan Kapata, Esam I. Azhar, Marjorie Pollack, Lawrence C. Madoff, Davidson H. Hamer, Jean B. Nachega, N. Pshenichnaya, Alimuddin Zumla Apr 2020

Covid-19 Travel Restrictions And The International Health Regulations - Call For An Open Debate On Easing Of Travel Restrictions, Eskild Petersen, Brian Mccloskey, David S. Hui, Richard Kock, Francine Ntoumi, Ziad A. Memish, Nathan Kapata, Esam I. Azhar, Marjorie Pollack, Lawrence C. Madoff, Davidson H. Hamer, Jean B. Nachega, N. Pshenichnaya, Alimuddin Zumla

Coronavirus COVID-19 Publications by UMMS Authors

The COVID-19 pandemic caused by the novel coronavirus (SARS-CoV-2) has made national governments worldwide to mandate several generic infection control measures such as physical distancing, self-isolation, and closure of non-essential shops, restaurants schools, among others. Some models suggest physical distancing would have to persist for 3 months to mitigate the peak effects on health systems and could be required on an intermittent basis for 12 to 18 months (Flaxman et al., 2020).


Trim34 Restricts Hiv-1 And Siv Capsids In A Trim5alpha-Dependent Manner, Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, Michael Emerman Apr 2020

Trim34 Restricts Hiv-1 And Siv Capsids In A Trim5alpha-Dependent Manner, Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, Michael Emerman

Open Access Articles

The HIV-1 capsid protein makes up the core of the virion and plays a critical role in early steps of HIV replication. Due to its exposure in the cytoplasm after entry, HIV capsid is a target for host cell factors that act directly to block infection such as TRIM5alpha and MxB. Several host proteins also play a role in facilitating infection, including in the protection of HIV-1 capsid from recognition by host cell restriction factors. Through an unbiased screening approach, called HIV-CRISPR, we show that the CPSF6-binding deficient, N74D HIV-1 capsid mutant is sensitive to restriction mediated by human TRIM34 ...


Identification Of Staphylococcus Aureus In State Fair Samples, Ana Castillo Jimenez Apr 2020

Identification Of Staphylococcus Aureus In State Fair Samples, Ana Castillo Jimenez

Research and Scholarship Symposium Posters

No abstract provided.