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Full-Text Articles in Life Sciences

Weighted Pathway Genetic Load Analysis Of Hyperbilirubinemic Infants Indicates A Potential Genetic Component For Susceptibility To Bilirubin Neurotoxicity, Sean M. Riordan, Jean-Baptiste Lepichon, Steven Shapiro, John Cowden, Monica Villagullen, Laurence Thielemans, Dina Villanueva Garcia, Jesus Aguirre-Hernandez Apr 2019

Weighted Pathway Genetic Load Analysis Of Hyperbilirubinemic Infants Indicates A Potential Genetic Component For Susceptibility To Bilirubin Neurotoxicity, Sean M. Riordan, Jean-Baptiste Lepichon, Steven Shapiro, John Cowden, Monica Villagullen, Laurence Thielemans, Dina Villanueva Garcia, Jesus Aguirre-Hernandez

Posters

Severe kernicterus spectrum disorder (KSD) is described as motor and auditory deficits resulting from brain damage caused by hyperbilirubinemia. The severity of HB does not always predict the severity of injury. The lack of a strong monogenetic link to susceptibility suggests bilirubin-induced brain damage may be due to impaired bilirubin response pathways. This poster describes work to use a modified pathway genetic load (mPGL) score method to perform a targeted genetic analysis of whole exome data from patients with various degrees of neonatal HB, with an ultimate goal of developing a neonatal screen to susceptibiltiy to bilirubin neurotoxicity.


Developing Technologically Advanced Research In Low- And Middle-Income Countries, Isa Abdulkadir, Tina Slusher, Fidelia Bode-Thomas, Sean Riordan, Jean-Baptiste Lepichon, Laila Hassan, Shehu Abdullahi, Akinyemi Ofakunrin, Stephen Oguche, Steven Shapiro, William Ogala Apr 2019

Developing Technologically Advanced Research In Low- And Middle-Income Countries, Isa Abdulkadir, Tina Slusher, Fidelia Bode-Thomas, Sean Riordan, Jean-Baptiste Lepichon, Laila Hassan, Shehu Abdullahi, Akinyemi Ofakunrin, Stephen Oguche, Steven Shapiro, William Ogala

Posters

This poster presents a collaboration between a group of scientists in Nigeria and the USA in developing a genomic research project and the solutions adopted in tackling the ethical implications and partnership equity and ownership of such a project.


Mutagenesis At Amino Acid Phosphorylation Sites Of The Human Erh Protein, Markaylia Grant Jul 2018

Mutagenesis At Amino Acid Phosphorylation Sites Of The Human Erh Protein, Markaylia Grant

Posters@Research Events

The goal of this project is to successfully create plasmids containing mutant human enhancer rudimentary, e(r) genes. The e(r) gene encodes for the protein, enhancer rudimentary homolog (ERH), which has been shown to promote the progression and survival of certain human cancers. These plasmids containing the mutant human genes will be inserted into the genome of Drosophila melanogaster, the common fruit fly, to study the effects of the mutations on the activity of the protein.


College Student Alcohol Use And Engagement In Prevention Programming, Alexis H. Branch, Shimona Kumar, Christina Mcgrath Jan 2018

College Student Alcohol Use And Engagement In Prevention Programming, Alexis H. Branch, Shimona Kumar, Christina Mcgrath

Undergraduate Research Posters

Social problems and adverse consequences have been associated with risky alcohol use (Paschall et al, 2015). Personalized Normative Feedback (PNF) has been utilized to address these problems (White and Hingson, 2014) by comparing students’ alcohol use to campus or national norms (Butler et al, 2009). The current investigation sought to understand differences in alcohol use behaviors in freshmen who did and did not report completion of a personalized feedback intervention (PFI) in a diverse sample of college students from the Spit for Science (S4S) project. S4S is a campus-wide, longitudinal study on the genetic and environmental factors that contribute to ...


2018 Annual Report, Christopher C. Witt Jan 2018

2018 Annual Report, Christopher C. Witt

Annual Reports

In 2018, the Museum of Southwestern Biology (MSB) has continued to improve its profile and impacts, both on the University of New Mexico campus and in the international scientific community. Its collections serve as scientific infrastructure that enhances research, teaching, community service, and public outreach. The MSB is part of the UNM Department of Biology, and the missions of the MSB and the Department are synergistic. MSB houses extensive and rapidly growing collections representing biodiversity of world, primarily from the last halfcentury. MSB has outstanding collections from New Mexico and western North America, but it also has substantial holdings from ...


Maine Twin Party Papers, 1938-1976, Special Collections, Raymond H. Fogler Library, University Of Maine Jan 2018

Maine Twin Party Papers, 1938-1976, Special Collections, Raymond H. Fogler Library, University Of Maine

Finding Aids

Welton P. Farrow was born in Tryon, Prince Edward Island, Canada, on December 10, 1898 with his twin brother, Harold J. Farrow. In 1938, after 18 years of living apart, they visited each other in Waterville, Maine, and at the request of a researcher named D. C. Rife from the University of Ohio, they invited pairs of twins to meet together in order to conduct research on the subjects of twins.

Collection, 1938-1976, consists of the papers of the Maine Twin Party organization. Includes correspondence, photographs, clippings, scrapbooks, and a film reel documenting their semi-annual parties celebrating twins, and their ...


The Subject Librarian Newsletter, Biology, Spring 2017, Sandy Avila Jan 2017

The Subject Librarian Newsletter, Biology, Spring 2017, Sandy Avila

Libraries' Newsletters

No abstract provided.


Separation Of Blood Mixtures Using Fluorescently Labeled Antibodies, Christopher Ehrhardt, Dani Jabado, Emily Brocato Jan 2017

Separation Of Blood Mixtures Using Fluorescently Labeled Antibodies, Christopher Ehrhardt, Dani Jabado, Emily Brocato

Undergraduate Research Posters

Identifying and analyzing biological mixture samples at a crime scene are of paramount concern for forensic scientists, especially if that type of evidence contains only one cell type. The presence of multiple contributors in a biological evidence sample reduces the probative value of DNA evidence and can sometimes lead to its eventual loss of value. As such, this study was performed in an attempt to examine and evaluate flow cytometry analysis as a means to separate blood mixture samples labeled with fluorescent antibodies. Fluorescein Isothiocyanate (FITC) antibodies were specifically targeted and bound to HLA (Human Leukocyte Antigens) markers present on ...


Principles Of Biology, Robert Bear, David Rintoul, Bruce Snyder, Martha Smith-Caldas, Christopher Herren, Eva Horne Jan 2016

Principles Of Biology, Robert Bear, David Rintoul, Bruce Snyder, Martha Smith-Caldas, Christopher Herren, Eva Horne

Open Access Textbooks

This textbook is designed specifically for Kansas State's Biology 198 Class. The course is taught using the studio approach and based on active learning. The studio manual contains all of the learning objectives for each class period and is the record of all student activities. Hence, this textbook is more of a reference tool while the studio manual is the learning tool.

The textbook was originally published and is also available to download at http://cnx.org/contents/db89c8f8-a27c-4685-ad2a-19d11a2a7e2e@24.1.It is licensed under a Creative Commons Attribution License 4.0 license.


Smoking Patterns Among Vcu Students, Jasmine Saini Jan 2015

Smoking Patterns Among Vcu Students, Jasmine Saini

Undergraduate Research Posters

For some individuals, college can be a high risk time for the development of problems associated with alcohol use and other substances. The purpose of this study is to examine these initiation and use patterns as they relate to nicotine use among college students 18 years of age and older enrolled in Spit for Science: The VCU Student Survey. The Spit for Science research project evaluates how genetic and environmental factors contribute to substance use and emotional health among college students at VCU. This study uses data from the Spit for Science 2011 cohort (n=2007) to investigate smoking patterns ...


The Kent State University Symposium On Aging: Life In The Balance: Fall Prevention From Multidisciplinary Perspectives, Kent State University - Kent Campus Nov 2014

The Kent State University Symposium On Aging: Life In The Balance: Fall Prevention From Multidisciplinary Perspectives, Kent State University - Kent Campus

Researcher Directories, Division of Research and Sponsored Programs

16 page booklet on research in Aging and Fall prevention.


An Exploration Of Fern Genome Space, Paul G. Wolf, Emily B. Sessa, D. Blaine Marchant, Fay-Wei Li, Carl J. Rothfels, Erin M. Sigel, Mathew A. Gitzendanner, Clayton J. Visger, Jo Ann Banks, Douglas E. Soltis, Pamela S. Soltis, Kathleen M. Pryer, Joshua P. Der Jul 2014

An Exploration Of Fern Genome Space, Paul G. Wolf, Emily B. Sessa, D. Blaine Marchant, Fay-Wei Li, Carl J. Rothfels, Erin M. Sigel, Mathew A. Gitzendanner, Clayton J. Visger, Jo Ann Banks, Douglas E. Soltis, Pamela S. Soltis, Kathleen M. Pryer, Joshua P. Der

An Exploration of Fern Genome Space

Ferns are one of the few remaining major clades of land plants for which a complete genome sequence is lacking. Knowledge of genome space in ferns will enable broad-scale comparative analyses of land plant genes and genomes, provide insights into genome evolution across green plants, and shed light on genetic and genomic features that characterize ferns, such as their high chromosome numbers and large genome sizes. As part of an initial exploration into fern genome space, we used a whole genome shotgun sequencing approach to obtain low-density coverage (1X to 2X) for six fern species from the Polypodiales (Ceratopteris, Pteridium ...


Function Of A Novel Checkpoint Protein In The Germ Line, Steven Drellishak, Marina Bykova, G. Valentin Börner Sep 2013

Function Of A Novel Checkpoint Protein In The Germ Line, Steven Drellishak, Marina Bykova, G. Valentin Börner

Undergraduate Research Posters 2013

Successful reproduction of Saccharomyces cerevisiae relies on the organism’s ability to complete the meiotic cell cycle and produce viable gametes. Zip1 is a protein that constitutes the central component of a protein structure that connects homologous chromosomes known as the synaptonemal complex. Zip1 is important for progression through the meiotic cell cycle. The C terminus of the coiled-coil Zip 1 protein is responsible for localization to the axes of the chromosomes. An internal deletion near the C terminus of Zip1, called zip1-c1, yields a stronger meiotic arrest than a mutation where Zip1 is completely deleted. The more efficient meiotic ...


Structure-Function Of U11 Snrna In The Minor Splicing Pathway, Mark P. Biro, Jagjit Singh Sep 2012

Structure-Function Of U11 Snrna In The Minor Splicing Pathway, Mark P. Biro, Jagjit Singh

Undergraduate Research Posters 2012

In human, the majority of protein coding genes are interrupted by dispensable intervening sequences (introns). These introns are removed by nuclear precursor (pre) mRNA splicing process to produce a mature mRNA needed for productive protein production in the cell. We are studying the splicing of minor class or U12-type introns which are spliced by U11, U12, U4atac, U5 and U6atac snRNAs. U11 snRNA binds to the 5’ end or splice site of the intron by RNA-RNA base-pairing to initiate the splicing process. Our results show the functionality of the genetic mutation suppressor assay in establishing the role of U11 snRNA ...


Role Of Histone Modifications In Meiosis, Mason Allen, Neeraj Joshi Sep 2012

Role Of Histone Modifications In Meiosis, Mason Allen, Neeraj Joshi

Undergraduate Research Posters 2012

Meiosis I is characterized by events taking place between homologous chromosomes called crossing over in which double stand breaks (DSB) are formed and repaired using the homologous chromosome as a template. To see if Gene A shared the same role as Gene B, double mutants were created to test chromosome segregation and DSB repair as compared with Gene B deletions. The spore viability of double mutants and their potential implications will be discussed.


Identification Of Novel Meiotic Genes Via A Genetic Screen, Steven David Zimmerman, Rima Sandhu Sep 2012

Identification Of Novel Meiotic Genes Via A Genetic Screen, Steven David Zimmerman, Rima Sandhu

Undergraduate Research Posters 2012

Proper segregation of chromosomes in Meiosis I requires proper function of the Synaptonemal Complex (SC), a zipper-like protein structure that facilitates recombination events and segregation of homologous chromosomes. Candidates which suppress the phenotype show sporulation and fluorescence on media, and have higher spore viabilities compared to our Zip1C1 control.


Yeast 2-Hybrid Screen For T. Brucei Tin2- And Rap1- Intracting Proteins, Miao Wang, Fan Wu Sep 2012

Yeast 2-Hybrid Screen For T. Brucei Tin2- And Rap1- Intracting Proteins, Miao Wang, Fan Wu

Undergraduate Research Posters 2012

Telomeres are DNA-protein complexes located at the ends of linear chromosomes. Acting like a cap, they protect chromosome ends from degradation and rearrangement, maintaining genomic stability. Our lab has identified several T. brucei telomere proteins, including TRF (TTAGGG Repeat-binding Factor), TIN2 (TRF1-interacting Nulcear Protein 2) and RAP1 (Repressor Activator Protein 1) homologs. We are currently verifying the interactions between the new candidates and TbTIN2 or TbRAP1.


Improved Performance Of Marron Using Genetic And Pond Management Strategies, Craig Lawrence Mar 2007

Improved Performance Of Marron Using Genetic And Pond Management Strategies, Craig Lawrence

(Fisheries) research contract reports

Marron (Cherax cainii) are the highest valued freshwater crayfish farmed in Australia. This project addressed the need to increase the profitability of commercial marron farms by improving growth rates and pond management strategies.


Ewe And Wether Trials - Tools For Benchmarking Your Sheep Genetics, Lock Butler Apr 2006

Ewe And Wether Trials - Tools For Benchmarking Your Sheep Genetics, Lock Butler

Bulletins 4000 -

Research and sheep productivity trial results demonstrate a huge variability in genetic productivity between flocks. For example a range of up to 2 kg clean fleece weight, 5 microns, 55 percentage points in lambing percentage and 20 kg live weight, can lead to big differences in gross margin between flocks.

There is an opportunity for genetic improvement, depending on your current ram source or sires performance. For example, Western Australian (WA) Wether Trial results suggest half the WA flocks could improve clean fleece weight per head by half a kilogram or more. The trial results suggest that this could occur ...