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Genetics and Genomics

Veterinary Microbiology and Preventive Medicine Publications

Fluoroquinolone

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Fitness Of Antimicrobial-Resistant Campylobacter And Salmonella, Qijing Zhang, Orhan Sahin, Patrick F. Mcdermott, Sophie Payot Jun 2006

Fitness Of Antimicrobial-Resistant Campylobacter And Salmonella, Qijing Zhang, Orhan Sahin, Patrick F. Mcdermott, Sophie Payot

Veterinary Microbiology and Preventive Medicine Publications

Campylobacter and Salmonella are the most commonly reported bacterial causes of human foodborne infections, and increasing proportions of these pathogens become resistant to medically important antimicrobial agents, imposing a burden on public health. Acquisition of resistance to antibiotics affects the adaptation and evolution of Salmonella and Campylobacter in various environments. Many resistance-conferring mutations entail a biological fitness cost, while others (e.g. fluoroquinolone resistance in Campylobacter) have no cost or even enhanced fitness. In Salmonella, the fitness disadvantage due to antimicrobial resistance can be restored by acquired compensatory mutations, which occur both in vitro and in vivo. The compensated or ...