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Full-Text Articles in Life Sciences

Growth, Lipid Production And Biodiesel Potential Of Chromulina Freiburgensis Dofl., An Acidophilic Chrysophyte Isolated From Berkeley Pit Lake, June E. Mohler Mitman Mar 2109

Growth, Lipid Production And Biodiesel Potential Of Chromulina Freiburgensis Dofl., An Acidophilic Chrysophyte Isolated From Berkeley Pit Lake, June E. Mohler Mitman

Graduate Theses & Non-Theses

Microalgae remain a promising, but underdeveloped source of lipids for sustainable biodiesel. Some of the obstacles to cost-effective commercial-scale production have been culture contamination and expensive harvest methods. A chrysophyte isolated from Berkeley Pit Lake and identified as Chromulina freiburgensis, was found to grow rapidly in a pH 2.5 liquid medium and to amass numerous intracellular lipid bodies. This research addresses the scarcity of published knowledge on the topic of chrysophyte species as potential lipid sources for biodiesel. It investigates how growth phase, culture conditions, and harvest timing influence the quantity and composition of lipids produced by this alga ...


Oil Preference In Ants And Arthropod Diversity In Urban Environments, Itzel Guzman-Hernandez Dec 2019

Oil Preference In Ants And Arthropod Diversity In Urban Environments, Itzel Guzman-Hernandez

Honors Theses

The success of certain ant species in urban areas is largely unknown. Available food in the environment could affect the composition of ants in urban areas due to a possible relationship between ant physiology and diet. I tested the oil preference of ants as a function of available arthropod prey in urban environments. I hypothesized that as arthropod diversity decreased, ant abundance at oil baits would decrease. Oil is an important nutrient that can affect ant body functions and activities. Ant foraging activities have been found to be affected by lipid depletion. A food source where ants can obtain oil ...


Oscillation In Mathematical Epidemiology, Meredith Greer Oct 2019

Oscillation In Mathematical Epidemiology, Meredith Greer

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Quantifying The Predictability Of Evolution At The Genomic Level In Lycaeides Butterflies, Samridhi Chaturvedi Aug 2019

Quantifying The Predictability Of Evolution At The Genomic Level In Lycaeides Butterflies, Samridhi Chaturvedi

All Graduate Theses and Dissertations

Stephen Jay Gould, a great scientist and evolutionary biologists, suggested that if we could replay the tape of life, we would not have observed similar course of events because evolution is stochastic and if affected by several events. Since then, the possibility that evolution is repeatable or predictable has been debated. Studies using large-scale evolution experiments, long-term data for individual populations, and controlled experiments in nature, have demonstrated phenotypic and genetic convergence in several taxa. These studies suggest that despite some randomness, predictable evolutionary patterns can emerge on a large temporal and spatial scale. However, a few cases also exist ...


Eared Grebe Nesting Ecology And Chronology Along The Great Salt Lake, Utah, Leah M. Delahoussaye Aug 2019

Eared Grebe Nesting Ecology And Chronology Along The Great Salt Lake, Utah, Leah M. Delahoussaye

All Graduate Theses and Dissertations

Eared Grebes (Podiceps nigricollis) are migratory birds that build their nests over water and in large groups called colonies. Their typical breeding range is in central southern Canada and northern United States; however, a previously uncertain number of Eared Grebes (grebes) also nest around the Great Salt Lake (GSL), Utah, at the southern edge of their breeding range. Little is known about the habitat requirements for grebe nesting colonies at such low latitudes and if they are different from colonies found elsewhere. My objectives for this research were to determine the status of the grebe nesting population as well as ...


Integrating Arthropod And Weed Management In A Water-Stressed Agro-Ecosystem, Ricardo Ramirez Jun 2019

Integrating Arthropod And Weed Management In A Water-Stressed Agro-Ecosystem, Ricardo Ramirez

Funded Research Records

No abstract provided.


A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn Jun 2019

A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn

Troy T. Rohn

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fragment of apoE4 (nApoE41-151) localizes within the nucleus of microglia in the human AD brain, suggesting a potential role in gene expression. In the present study, we investigated this possibility utilizing BV2 microglia cells treated exogenously with nApoE41-151. The results indicated that nApoE41-151 leads to morphological activation of microglia cells through, at least in part, the ...


A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn Jun 2019

A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn

Eric J. Hayden

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fragment of apoE4 (nApoE41-151) localizes within the nucleus of microglia in the human AD brain, suggesting a potential role in gene expression. In the present study, we investigated this possibility utilizing BV2 microglia cells treated exogenously with nApoE41-151. The results indicated that nApoE41-151 leads to morphological activation of microglia cells through, at least in part, the ...


A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn Jun 2019

A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn

Brad E. Morrison

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fragment of apoE4 (nApoE41-151) localizes within the nucleus of microglia in the human AD brain, suggesting a potential role in gene expression. In the present study, we investigated this possibility utilizing BV2 microglia cells treated exogenously with nApoE41-151. The results indicated that nApoE41-151 leads to morphological activation of microglia cells through, at least in part, the ...


Structure-Based Design Of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses To A Conserved Epitope, Brian G. Pierce, Elisabeth N. Boucher, Kurt H. Piepenbrink, Ejemel Monir, Chelsea A. Rapp, William D. Thomas Jr., Eric J. Sundberg, Zhiping Weng, Yan Wang Jun 2019

Structure-Based Design Of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses To A Conserved Epitope, Brian G. Pierce, Elisabeth N. Boucher, Kurt H. Piepenbrink, Ejemel Monir, Chelsea A. Rapp, William D. Thomas Jr., Eric J. Sundberg, Zhiping Weng, Yan Wang

Kurt Piepenbrink

Despite recent advances in therapeutic options, hepatitis C virus (HCV) remains a severe global disease burden, and a vaccine can substantially reduce its incidence. Due to its extremely high sequence variability, HCV can readily escape the immune response; thus, an effective vaccine must target conserved, functionally important epitopes. Using the structure of a broadly neutralizing antibody in complex with a conserved linear epitope from the HCV E2 envelope glycoprotein (residues 412 to 423; epitope I), we performed structure-based design of immunogens to induce antibody responses to this epitope. This resulted in epitope-based immunogens based on a cyclic defensin protein, as ...


Hawk On Wire: Ecopoems By Scott T. Starbuck, Vivian M. Hansen Jun 2019

Hawk On Wire: Ecopoems By Scott T. Starbuck, Vivian M. Hansen

The Goose

Review of Scott T. Starbuck’s Hawk on Wire: Ecopoems


Two Notes On Nabokov, Victor Fet Jun 2019

Two Notes On Nabokov, Victor Fet

Victor Fet

No abstract provided.


Diuretic, Glucosuric And Natriuretic Effect Of Pantoyltaurine In Diabetic Sprague-Dawley Rats, Ripal P. Amin, Sanket N. Patel, Sunil Kumar, S. William Zito, Sue Ford, Michael A. Barletta Jun 2019

Diuretic, Glucosuric And Natriuretic Effect Of Pantoyltaurine In Diabetic Sprague-Dawley Rats, Ripal P. Amin, Sanket N. Patel, Sunil Kumar, S. William Zito, Sue Ford, Michael A. Barletta

Dr. Sunil Kumar

Sodium-glucose co-transporter (SGLT) inhibitors offer a novel tool to control hyperglycemia and its complications. We present preliminary findings of pantoyltaurine, N-substituted analog of taurine, as diuretic, glucosuric and natriuretic agent in streptozotocin (60 mg/kg/mL, i.p.)-induced type 1 diabetic Sprague-Dawley rats and whether pantoyltaurine has an effect on regulation of SGLT isoforms that may further help in reducing hyperglycemia and improving renal function. After 14 days of persistent diabetes, phlorizin (0.4 g/kg/day, s.c.) or pantoyltaurine (2.4 mM/kg/day, p.o.) was administered for three weeks, days 15 - 35. As expected, diabetic ...


Tracking Residual-Yolk Energy In Dormant Hatchling Turtles, Tom Pham, Dr. Tim J. Muir, Samira Radi, Jacob Wyco Jun 2019

Tracking Residual-Yolk Energy In Dormant Hatchling Turtles, Tom Pham, Dr. Tim J. Muir, Samira Radi, Jacob Wyco

Celebration of Learning

Hatchling painted turtles (Chrysemys picta) spend their first winter inside natal nests without food and must rely on maternally derived energy in the form of residual yolk for up to nine months. In this study, we take a closer look at the use and movement of residual-yolk energy during the first 33 weeks (~8 mo.) after hatching by measuring changes in mass, lipid content, & protein content of yolk, liver, small intestine, and carcass. Our data showed a significant decrease in yolk mass by 64% and significant increases in carcass & liver masses of 9% & 16%, respectively, during the first 2 weeks ...


Place-Based Learning Communities On A Rural Campus: Turning Challenges Into Assets, Amy Sprowles, Katlin Goldenberg, P. Dawn Goley, Steve Ladwig, Frank J. Shaughnessy, Kerri J. Malloy, Cutcha R. Baldy, Monty M. Mola, Joshua R. Smith, Mark A. Hemphill-Haley, Melanie J. Michalak, Claire P. Till, Alison P. O'Dowd, Gillian Black, Patricia L. Siering, Eileen Cashman, Alexandru M.F. Tomescu, Matthew P. Hurst, Bori Mazzag, Sonja Manor, Dale R. Oliver, Jeffrey R. Dunk, Jeffrey Abell, Micaela S. Gunther, Andre Buchheister, Ruth Saunders, James Floss, Erin Sullivan, Sarah Ben-Zvi, Matthew D. Johnson Jun 2019

Place-Based Learning Communities On A Rural Campus: Turning Challenges Into Assets, Amy Sprowles, Katlin Goldenberg, P. Dawn Goley, Steve Ladwig, Frank J. Shaughnessy, Kerri J. Malloy, Cutcha R. Baldy, Monty M. Mola, Joshua R. Smith, Mark A. Hemphill-Haley, Melanie J. Michalak, Claire P. Till, Alison P. O'Dowd, Gillian Black, Patricia L. Siering, Eileen Cashman, Alexandru M.F. Tomescu, Matthew P. Hurst, Bori Mazzag, Sonja Manor, Dale R. Oliver, Jeffrey R. Dunk, Jeffrey Abell, Micaela S. Gunther, Andre Buchheister, Ruth Saunders, James Floss, Erin Sullivan, Sarah Ben-Zvi, Matthew D. Johnson

Learning Communities Research and Practice

At Humboldt State University (HSU), location is everything. Students are as drawn to our spectacular natural setting as they are to the unique majors in the natural resource sciences that the university has to offer. However, the isolation that nurtures the pristine natural beauty of the area presents a difficult reality for students who are accustomed to more densely populated environments. With the large majority of our incoming students coming from distant cities, we set out to cultivate a “home away from home” by connecting first-year students majoring in science, technology, engineering and math (STEM) to the communities and local ...


Effects Of Life-Long Wheel Running Behavior On Plantar Flexor Contractile Properties, Alexander Nicholas Beechko Jun 2019

Effects Of Life-Long Wheel Running Behavior On Plantar Flexor Contractile Properties, Alexander Nicholas Beechko

Electronic Theses, Projects, and Dissertations

Aging in skeletal muscle is characterized by a loss in muscular performance. This is in part related to the direct loss of muscle mass due to senescence, known as sarcopenia. With age, skeletal muscles lose force production, contractile speed, and power production. The force velocity relationship of muscle is a product of force production and contraction speed, both of which decline with age; however, the mechanisms and trajectory of this decline are not well understood. Exercise has positive effects on muscle, and thus may assist in maintaining performance in old age. However, few long-term studies have been performed to examine ...


Availability Of Microtrash Materials And Selectivity By California Condors, Marie G. Solis Jun 2019

Availability Of Microtrash Materials And Selectivity By California Condors, Marie G. Solis

Biological Sciences

California condors consume non-food items, including anthropogenic waste, and provision it to their young. Consuming “microtrash” can cause mortality, especially in nestlings. There are several hypotheses explaining why condors might consume microtrash. These hypotheses assume condors exhibit a preference for the type of material. Therefore, we test the assumption that when California condors take microtrash, they display material selectivity. We did this by sampling microtrash from roadside pullouts in the Los Padres National Forest. Those samples were compared to condor necropsy and nest microtrash data, categorized by material type: glass, plastic, metal, and other. We find that in our analysis ...


Metabolism Underlies Physiological Homeostasis In Drosophila, Omera B. Matoo, Cole R. Julick, Kristi Montooth Jun 2019

Metabolism Underlies Physiological Homeostasis In Drosophila, Omera B. Matoo, Cole R. Julick, Kristi Montooth

Faculty Publications in the Biological Sciences

Organismal physiology emerges from metabolic pathways and subcellular structures like the mitochondria that can vary across development and among individuals. Here, we tested whether genetic variation at one level of physiology can be buffered at higher levels of biological organization during development by the inherent capacity for homeostasis in physiological systems. We found that the fundamental scaling relationship between mass and metabolic rate, as well as the oxidative capacity per mitochondria, changed significantly across development in the fruit fly Drosophila. However, mitochondrial respiration rate was maintained at similar levels across development. Furthermore, larvae clustered into two types—those that switched ...


The Potential Of Socio-Biologically Relevant Mobile Applications To Attract Girls To Stem, Vanaja Nethi, Santanu De May 2019

The Potential Of Socio-Biologically Relevant Mobile Applications To Attract Girls To Stem, Vanaja Nethi, Santanu De

Santanu De

Stimulating girls’ interest in science, technology, engineering and mathematics (STEM) when they are in school, and sustaining that interest, is critical in motivating girls to choose STEM-related disciplines in higher education and enter STEM careers. Research indicates that girls show an interest in STEM until about 11-12 years of age, but this starts to wane by the time they are 15-16 years. Thus, there is a clear need to focus on sustaining the interest of girls in STEM at middle or high school levels. Research has shown that one of the main drivers that impact girls’ interest in STEM is ...


Invertebrate Diversity Of Ponds Within Gremel Wildlife Sanctuary And Amboy Marsh, Dalton Howard, Madison Lape May 2019

Invertebrate Diversity Of Ponds Within Gremel Wildlife Sanctuary And Amboy Marsh, Dalton Howard, Madison Lape

Celebration of Learning

This project tested the water quality of different ponds and used macroinvertebrates as the overall indicator. The invertebrates give us a lot of knowledge about the health of the ecosystem and possible pollutants that could be harming the environments.


Do Stands Of Native Trees Harbor Different Invasive Species Than Stands Of Planted Pine?, Carly Mccameron, John Mccarthy, Dr. Kevin Geedey May 2019

Do Stands Of Native Trees Harbor Different Invasive Species Than Stands Of Planted Pine?, Carly Mccameron, John Mccarthy, Dr. Kevin Geedey

Celebration of Learning

The most outstanding invasive species that can be found at Augustana’s Green Wing Environmental Laboratory are honeysuckle, buckthorn, multiflora rose, garlic mustard, autumn olive, and oriental bittersweet. These plants are not only disrupting the ecosystem at Green Wing, but they are doing it all over the country. The result of their disruption is that they have taken over entire habitats and left natural species with no way to compete for survival. To study this we used the line-point method as well as other forms of data collection to compare a non-native pine tree habitat to an area dominated by ...


The Potential Of Socio-Biologically Relevant Mobile Applications To Attract Girls To Stem, Vanaja Nethi, Santanu De May 2019

The Potential Of Socio-Biologically Relevant Mobile Applications To Attract Girls To Stem, Vanaja Nethi, Santanu De

FDLA Journal

Stimulating girls’ interest in science, technology, engineering and mathematics (STEM) when they are in school, and sustaining that interest, is critical in motivating girls to choose STEM-related disciplines in higher education and enter STEM careers. Research indicates that girls show an interest in STEM until about 11-12 years of age, but this starts to wane by the time they are 15-16 years. Thus, there is a clear need to focus on sustaining the interest of girls in STEM at middle or high school levels. Research has shown that one of the main drivers that impact girls’ interest in STEM is ...


Differences In Stress Reactivity Between Zebrafish With Alternative Stress Coping Styles, Ryan Y. Wong, Jeffrey French, Jacalyn B. Russ May 2019

Differences In Stress Reactivity Between Zebrafish With Alternative Stress Coping Styles, Ryan Y. Wong, Jeffrey French, Jacalyn B. Russ

Biology Faculty Publications

Animals experience stress in a variety of contexts and the behavioural and neuroendocrine responses to stress can vary among conspecifics. The responses across stressors often covary within an individual and are consistently different between individuals, which represent distinct stress coping styles (e.g. proactive and reactive). While studies have identified differences in peak glucocorticoid levels, less is known about how cortisol levels differ between stress coping styles at other time points of the glucocorticoid stress response. Here we quantified whole-body cortisol levels and stress-related behaviours (e.g. depth preference, movement) at time points representing the rise and recovery periods of ...


Whole Blueberry Protects Pancreatic Beta-Cells In Diet-Induced Obese Mouse, Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang, Xiaoqing Tang May 2019

Whole Blueberry Protects Pancreatic Beta-Cells In Diet-Induced Obese Mouse, Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang, Xiaoqing Tang

Department of Biological Sciences Publications

Background

Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to determine how blueberry affects glucose metabolism and pancreatic β-cell proliferation in high fat diet (HFD)-induced obese mice.

Methods

Wild type male mice at age of 4 weeks received two different kinds of diets: high-fat diet (HFD) containing 60% fat or modified HFD supplemented with 4% (wt:wt) freeze-dried whole blueberry powder (HFD + B) for 14 weeks. A separate experiment was performed in mice fed with low-fat diet (LFD) containing ...


Differential Roles Of Mammalian Target Of Rapamycin Complexes 1 And 2 In Migration Of Prostate Cancer Cells, Smrruthi Vaidegi Venugopal May 2019

Differential Roles Of Mammalian Target Of Rapamycin Complexes 1 And 2 In Migration Of Prostate Cancer Cells, Smrruthi Vaidegi Venugopal

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

In this study, we investigated differential activation and the role of two mTOR complexes in cell migration of prostate cancer cells. Specific knock-down of endogenous RAPTOR and RICTOR by siRNA resulted in decreased cell migration in LNCaP, DU145, and PC3 cells indicating that both mTORC1 and mTORC2 are required for cell migration. EGF treatment induced the activation of both mTORC1 and mTORC2 as determined by complex-specific phosphorylation of mTOR protein. Specific knock-down or inhibition of Rac1 activity in PC3 cells blocked EGF-induced activation of mTORC2, but had no effect on mTORC1 activation. Furthermore, the over-expression of constitutively active Rac1 (Rac1Q61L ...


Role Of High Mobility Group A2 (Hmga2) In Prostate Cancer, Ohuod Hawsawi May 2019

Role Of High Mobility Group A2 (Hmga2) In Prostate Cancer, Ohuod Hawsawi

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

High mobility group A2 (HMGA2) is a non-histone protein highly expressed during the development but is low or absent in most adult tissues. Epithelial-mesenchymal transition (EMT) plays a critical role in prostate cancer progression and metastasis. HMGA2 has been shown to promote EMT in separate studies. Interestingly, wild-type HMGA2 and truncated (lacking the 3’UTR) HMGA2 isoforms are overexpressed in many cancers. However, there are no studies on the role of each isoform in prostate cancer progression. We hypothesized that wild-type and truncated HMGA2 promotes prostate cancer progression by different mechanisms. We analyzed the expression of HMGA2 in the prostate ...


Loss Of Id4 Promotes Stemness In Prostate Cancer Cells, Dhanushka Hewabostanthirige May 2019

Loss Of Id4 Promotes Stemness In Prostate Cancer Cells, Dhanushka Hewabostanthirige

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

Inhibitor of differentiation 4 (ID4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer (PCa). Recent studies have shown that Id4 is highly expressed in the normal prostate and decreases in prostate cancer due to epigenetic silencing. Id4 knockdown in androgen sensitive LNCaP cells has been shown to lead to castration resistant prostate cancer (CRPC) in vitro and in vivo. Id4-/- mice leads to underdeveloped prostate with PIN like lesions without the loss of Androgen Receptor (AR) expression. In this study we demonstrate that the loss of ID4 expression in PCa ...


Establishment Of Crispr/Cas-9 Aided Knockout Of The Zic2 Gene In The African-American Prostate Cancer Cell Line E006aa-Pr, Janelle Moore May 2019

Establishment Of Crispr/Cas-9 Aided Knockout Of The Zic2 Gene In The African-American Prostate Cancer Cell Line E006aa-Pr, Janelle Moore

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

The largest U.S. cancer health disparity exists in prostate cancer, with African American men having the highest incidence and mortality rates. The present study evaluated the effects of ZIC2 and the underlying mechanisms in the E006 parental African-American cell line that produces tumors at accelerated growth rates because of the increase of ZIC2 genes in African-American males. We analyzed the experimental research that the overexpression of ZIC2 contributes to progression of prostate cancer. E006AA cells with overexpressed or suppressed ZIC2 were analyzed to determine phenotypic differences, PCR, cell proliferation and immunoblot assays. The expression levels of ZIC2 were analyzed ...


Analysis Of Sublethal Toxicity In Developing Zebrafish Embryos Exposed To A Range Of Petroleum Substances Using Be-Spme And Whole Transcriptome Microarray, Bryan Matthew Hedgpeth May 2019

Analysis Of Sublethal Toxicity In Developing Zebrafish Embryos Exposed To A Range Of Petroleum Substances Using Be-Spme And Whole Transcriptome Microarray, Bryan Matthew Hedgpeth

Seton Hall University Dissertations and Theses (ETDs)

The OECD 236 Fish Embryo Acute Toxicity Test guideline relies on four endpoints to describe exposure related effects (coagulation, lack of somite formation, tail-bud detachment from yolk-sac, and presence of heartbeat). Danio rerio (zebrafish) embryos were used to investigate these endpoints along with a number of additional sublethal effects (i.e. cardiac dysfunction, pericardial edema, yolk sac edema, tail curvature, hatch success, pericardial edema area, craniofacial malformation, swim bladder development, fin development, and heart rate) following five day exposures to one of seven petroleum substances. The substances investigated included two crude oils, three gas oils, a diluted bitumen, and a ...


Socially Regulated Neural Circuits Activation Via Endocannabinoid And Dopaminergic Signaling In Zebrafish, Choongseok Park May 2019

Socially Regulated Neural Circuits Activation Via Endocannabinoid And Dopaminergic Signaling In Zebrafish, Choongseok Park

Biology and Medicine Through Mathematics Conference

No abstract provided.