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California Institute of Integral Studies

2014

Treatment-resistant depression

Articles 1 - 3 of 3

Full-Text Articles in Religion

Ketamine And Depression: A Review, Wesley C. Ryan, Cole J. Marta, Ralph J. Koek Jul 2014

Ketamine And Depression: A Review, Wesley C. Ryan, Cole J. Marta, Ralph J. Koek

International Journal of Transpersonal Studies

Ketamine, via intravenous infusions, has emerged as a novel therapy for treatment-resistant depression, given rapid onset and demonstrable efficacy in both unipolar and bipolar depression. Duration of benefit, on the order of days, varies between these subtypes, but appears longer in unipolar depression. A unique property is reduction in suicidality although data are more limited. Strategies to extend duration, via multiple doses, maintenance treatment, or subsequent augmenting medications have yielded mixed results. There is a relative paucity of data regarding alternate methods of administration such as intramuscular, intranasal, and oral routes, though preliminary results are promising. Adverse effects most reliably ...


Making Ketamine Work In The Long Run, Terrence S. Early Jul 2014

Making Ketamine Work In The Long Run, Terrence S. Early

International Journal of Transpersonal Studies

Treatments such as ketamine psychotherapy face substantial financial and regulatory obstacles to dissemination into widespread use. Newly patented medications are able to generate enough capital to pay for studies required for FDA approval, personnel to apply for coverage on insurance plans, and marketing to establish a successful launch. Ketamine is an older drug with considerable evidence of efficacy for treatment resistant depression, and almost 50 years of data concerning safety as an anesthetic agent. However, it can no longer be patented, so there is no incentive for pharmaceutical companies to help get it into widespread use. In this paper we ...


Ketamine For Depression: A Mixed-Methods Study, Philip E. Wolfson Jul 2014

Ketamine For Depression: A Mixed-Methods Study, Philip E. Wolfson

International Journal of Transpersonal Studies

Prior studies have reported variously on the presence or absence of dissociative effects at subanesthtetic doses of ketamine administered for treatment-resistant depression. This mixedmethods study emulated the protocol used for the studies in question, with IV administration of 0.5mg/kg over 40 minutes with eight experienced ketamine users. Quantitative measures were generally insignificant since this was not a population reporting depression; blood pressure increased as expected by 20-30mm systolic and 6-20mm diastolic, falling rapidly by 20 minutes after completion of the infusion. Individual qualitative reports reports of relaxation, pleasant sensation, decreased cognitive function, and some disabling of ordinary capacities ...