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Full-Text Articles in Arts and Humanities

The Discovery Of Modern Anaesthesia – Contributions Of Davy, Clarke, Long, Wells And Morton, Sukumar P. Desai, Manisha S. Desai, Chandrakant S. Pandav Dec 2007

The Discovery Of Modern Anaesthesia – Contributions Of Davy, Clarke, Long, Wells And Morton, Sukumar P. Desai, Manisha S. Desai, Chandrakant S. Pandav

Anesthesiology and Perioperative Medicine Publications

While many may argue as to who deserves the most credit for the discovery of modern anaesthesia, events in the late 18 th and early 19 th centuries led to the introduction and development of modern anaesthetic techniques. English physicist and chemist Humphry Davy [1778-1829] first became aware of the sedative and analgesic properties of nitrous oxide in 1795. Although he never experimented with the drug during a surgical procedure, he was the first to suggest that it would be beneficial in relieving pain during surgical procedures. The mind-altering properties of nitrous oxide and ether were often abused for recreational ...


Dna Polymerase Beta Is Able To Repair Breaks In Switch Regions And Plays An Inhibitory Role During Immunoglobulin Class Switch Recombination, Xiaoming Wu, Janet Stavnezer Jul 2007

Dna Polymerase Beta Is Able To Repair Breaks In Switch Regions And Plays An Inhibitory Role During Immunoglobulin Class Switch Recombination, Xiaoming Wu, Janet Stavnezer

Women’s Health Research Faculty Publications

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), which converts cytosines to uracils in switch (S) regions. Subsequent excision of dU by uracil DNA glycosylase (UNG) of the base excision repair (BER) pathway is required to obtain double-strand break (DSB) intermediates for CSR. Since UNG normally initiates faithful repair, it is unclear how the AID-instigated S region lesions are converted into DSBs rather than correctly repaired by BER. Normally, DNA polymerase beta (Polbeta) would replace the dC deaminated by AID, leading to correct repair of the single-strand break, thereby preventing CSR. We address the question ...