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Medicine and Health Sciences

University of Massachusetts Medical School

2006

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Full-Text Articles in Arts and Humanities

Impact Of Cyclooxygenase Inhibitors In The Women's Health Initiative Hormone Trials: Secondary Analysis Of A Randomized Trial, Judith Hsia, Joann E. Manson, Lewis H. Kuller, Mary B. Pettinger, John H. Choe, Robert D. Langer, Marian C. Limacher, Albert Oberman, Judith K. Ockene, Mary Jo O'Sullivan, Jennifer G. Robinson Sep 2006

Impact Of Cyclooxygenase Inhibitors In The Women's Health Initiative Hormone Trials: Secondary Analysis Of A Randomized Trial, Judith Hsia, Joann E. Manson, Lewis H. Kuller, Mary B. Pettinger, John H. Choe, Robert D. Langer, Marian C. Limacher, Albert Oberman, Judith K. Ockene, Mary Jo O'Sullivan, Jennifer G. Robinson

Women’s Health Research Faculty Publications

OBJECTIVES: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials. Estrogen increases COX expression, and inhibitors of COX such as nonsteroidal anti-inflammatory agents appear to increase coronary risk, raising the possibility of a clinically important interaction in the trials.

DESIGN: The hormone trials were randomized, double-blind, and placebo-controlled. Use of nonsteroidal anti-inflammatory drugs was assessed at baseline and at years 1, 3, and 6.

SETTING: The Women's Health Initiative hormone trials were conducted at ...